| Interacting proteins: P32780 and Q01094 |
Pubmed |
SVM Score :0.0 |
| We have investigated the spatial relationship between sites containing newly synthesized RNA and domains containing proteins involved in transcription , such as RNA polymerase 2 and the transcription factors TFIIH , Oct 1 , BRG 1 , E2F 1 and glucocorticoid receptors , using dual immunofluorescence labelling followed by confocal microscopy on cultured cells . ^^^ |
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| Interacting proteins: P32780 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Modular organization of the E2F1 activation domain and its interaction with general transcription factors TBP and TFIIH . ^^^ We have characterized interactions of the E2F1 activation domain with two general transcription factors , the TATA box binding protein ( TBP ) and TFIIH . ^^^ Neither of these minimal activation domains independently bound TFIIH ; rather , the TFIIH binding site of E2F1 overlaps both domains . ^^^ Loss of TFIIH binding by E2F1 resulted in a 60 65 % reduction in transactivation , suggesting that the E2F1 / TFIIH interaction is important , but not essential , for transactivation . ^^^ We have demonstrated that recombinant Rb can compete with TBP and the p 62 subunit of TFIIH for binding to immobilized E2F1 . ^^^ |
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| Interacting proteins: P32780 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Residues phosphorylated by TFIIH are required for E2F 1 degradation during S phase . ^^^ We demonstrate that TFIIH is responsible for the E2F 1 phosphorylation observed in cell extracts and that endogenous E2F 1 interacts in vivo with p 62 , a component of TFIIH , during S phase . ^^^ These results suggest that TFIIH mediated phosphorylation of E2F 1 plays a role in triggering E2F 1 degradation during S phase . . ^^^ |
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| Interacting proteins: P32780 and Q01094 |
Pubmed |
SVM Score :0.0 |
| The subunit p 62 is a structural component of the TFIIH core that is known to interact with VP 16 , p 53 , Eralpha , and E2F1 in the context of activated transcription , as well as with the endonuclease XPG in DNA repair . ^^^ |
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| Interacting proteins: P32780 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32780 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
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