| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.5157768 |
| The in vitro interaction of cyclin A 1 with E2F 1 was greatly enhanced when cyclin A 1 was complexed with CDK 2 . 0.5157768^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| In addition , the steady state levels of cyclin dependent kinases CDK 1 and CDK 2 and of transcription factor E2F 1 were diminished . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation analyses revealed an interaction of C / EBPalpha with p 107 but none with cdk 2 , E2F1 , or cyclin A . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that KA induced an increase in the expression of Cdk 2 , cyclin E and E2F 1 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| S / K deprivation induced the expression of cell cycle proteins such as cyclin E , cyclin A , cdk 2 , cdk 4 and E2F 1 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| The NPDC 1 protein has been shown to interact with the E2F1 transcription factor , D type cyclins and Cdk 2 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| This E2F 1 mediated induction of S phase and mitosis is not accompanied by the rise in either cyclin D associated kinase activity or cdk 2 activity that is normally observed during the G 1 phase of the cell cycle . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Selective repression of growth regulating cdk 2 , cyclin E and E2F1 genes in human cell senescence . ^^^ Therefore , the present results have indicated the selective repressions of cdk 2 , cyclin E and E2F1 in senescent cells . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| While the complex of cyclin A / CDK2 was required for stable complex formation with E2F 1 , the kinase active form of CDK 2 was not required . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| The Cdk 2 cyclin D 1 complex did not phosphorylate any tested substrates , such as H 1 histone , pRB , SV 40 large T antigen , p 53 , E2F 1 or a preparation of nuclear proteins from HeLa cells ; in contrast , Cdk 2 cyclin E and Cdk 2 cyclin A phosphorylated these proteins . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Synergistic gene expressions of cyclin E , cdk 2 , cdk 5 and E2F 1 during the prolactin induced G1 / S transition in rat Nb 2 pre T lymphoma cells . ^^^ The present study demonstrates that the genes of cyclin E , cdk 2 , cdk 5 and the transcriptional factor E2F 1 are expressed during the prolactin ( PRL ) induced G1 / S transition in rat Nb 2 pre T lymphoma cells . ^^^ These results suggest that cyclin E , cdk 2 , cdk 5 and E2F 1 play the roles in the G1 / S transition being expressed by a common cellular mechanism ( s ) in the PRL stimulated pre T lymphoma cells . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Induction of E2F 1 / DP 1 resulted in increased expression and activity of cyclins A and E , as well as CDK 2 , prior to S phase entry . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Re entry is accompanied by a reduction in un / hypophosphorylated pRB , an induction of cyclin D 1 and cdk 2 , but no change in cdk 4 , cyclin E , or E2F 1 . ^^^ Fabpi directed expression of E2F 1 does not cause villus enterocytes to return to the cell cycle , alter their suppression of cyclin D 1 or cdk 2 , or affect their state of differentiation , emphasizing the insensitivity of these cells to the effects of E2F 1 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis of BIP with cyclins / CDKs and E2F antisera indicated association with cdc 2 , cdk 2 , cdk 4 , cyclin B , cyclin D , cyclin A and E2F 4 but not with cdk 3 , cdk 5 , cdk 6 , E2F 1 , E2F 2 , E2F 3 , E2F 5 and cyclin E . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Lovastatin treatment increased protein and mRNA levels of the cyclin dependent kinase inhibitor p 21 ( WAF1 / CIP1 ) , increased binding of p 21 with Cdk 2 , markedly inhibited cyclin E and Cdk 2 associated phosphorylation of histone H 1 or GST retinoblastoma protein , enhanced binding of the retinoblastoma protein to the transcription factor E2F 1 in vivo , and induced the activation of a p 21 promoter reporter construct . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| In the search for new risk factors at the molecular and cellular levels , clinical data [ lymph node involvement ( LN ) and stage ] were used and 104 squamous cell lung carcinomas were analyzed by immuno histochemistry for expression of cyclin D 1 , cyclin A , cdk 2 , cdk 4 , RB , and E2F1 . ^^^ The results of the univariate analysis of all 8 factors showed that cyclin A and cdk 2 gave the best prognostic information , while no prognostic value could be found associated with cyclin D 1 , cdk 4 , RB and E2F1 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , a recently developed quantitative reverse transcriptase polymerase chain reaction method was used to assess simultaneously expression of 15 genes mechanistically associated with cell cycle control ( c myc , E2F 1 , p 21 , rb , PCNA , cyclin D 2 , cyclin D 3 , cyclin E , cdc 2 , CDK 2 , CDK 4 , mad , max p 21 , max p 22 , and p 53 ) in normal cell cultures from five individuals and in nine different malignant BEC lines . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Interestingly , we find that the histone H 1 kinase activity associated with an E2F 1 complex containing Cyclin A and Cdk 2 , but not that associated with Cyclin E , in late G 1 and early S phases is increased in cells containing hormone activated MycER , but not FosER . ^^^ Altogether , the data suggest that the presence of excessive Myc protein in keratinocytes can stimulate otherwise noncycling cells to enter the cell cycle , and that this effect of Myc involves both positive effects on E2F 1 associated Cdk 2 and negative effects on Cdk 4 in late G1 . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Bypassing CDK 2 inhibition requires an additional function of E1A : the mutant E1A Delta 26 35 does not overcome p 27 induced arrest , while it binds pRb family proteins , prevents p 16 induced arrest , and alleviates pRb mediated repression of E2F 1 transcriptional activity ( although E1A Delta 26 35 fails to restore expression of E2F regulated genes in p 27 arrested cells ) . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| However , E2F 1 and E2F 4 clearly regulate expression of distinct genes , demonstrated when E2F 4 caused a threefold increase in the levels of cdk 2 whereas E2F 1 failed to increase in this cyclin dependent kinase . ^^^ Similarly , expression of E2F 1 or E2F 2 were shown to have distinct effects on the expression of cdk 2 , cyclin E and pRB despite both of these closely related E2F family members potently inducing cell death . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Cdk 3 kinase activity is neither affected by p 16 ( in contrast to cdk4 / 6 ) nor by E2F 1 ( in contrast to cdk 2 ) , but is downregulated upon transient p 27 expression . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Increased cyclin E cdk 2 protein expression was accompanied by the inhibition of DNA synthesis , with a decrease in E2F 1 expression . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we used adenoviral gene transfer to express various E2F 1 and E1A proteins in neonatal rat cardiac myocytes that are already refractory to mitogenic serum , in the absence or presence of several complementary cell cycle inhibitors p 16 , p 21 , or dominant negative cyclin dependent kinase 2 ( Cdk 2 ) . ^^^ Rb binding by E2F 1 was neither necessary nor sufficient for G 1 exit , whereas DNA binding was required ; thus , exogenous E2F 1 did not merely function by competing for the Rb `` pocket . ' ' E2F 1 induced G 1 exit was blocked by the `` universal ' ' Cdk inhibitor p 21 but not by p 16 , a specific inhibitor of Cdk4 / 6 ; p 21 was permissive for E2F 1 induction of cyclins E and A , but prevented their stimulation of Cdk 2 kinase activity . ^^^ In addition , E2F 1 induced G 1 exit was blocked by dominant negative Cdk 2 . ^^^ Thus , E2F 1 induced Cdk 2 function was necessary , although not sufficient , to trigger DNA synthesis in cardiac muscle cells . ^^^ In summary , E1A binding to pocket proteins has effects beyond those produced by E2F 1 alone and can drive S phase entry that is resistant to p 21 and independent of an increase in Cdk 2 function . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| No difference in the treatment induced modulation of proteins involved in cell cycle progression ( cyclin A , cdk 2 , pRB , E2F 1 ) and apoptosis ( bcl 2 , bax ) was observed in the three clones . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Here we present evidence that activation of a cAMP pathway correlates with multiple cellular changes in these cells : ( 1 ) increased expression of the transcription factor microphthalmia ; ( 2 ) increased melanogenesis ; ( 3 ) increased association of the cyclin dependent kinase inhibitors ( CDK Is ) p 27 ( KIP 1 ) and p 16 ( INK 4 ) with CDK 2 and CDK 4 , respectively ; ( 4 ) failure to phosphorylate the retinoblastoma protein ( pRB ) ; ( 5 ) decreased expression of E2F1 , E2F2 , and E2F4 proteins ; ( 6 ) loss of E2F DNA binding activity ; and ( 7 ) phenotypic changes characteristic of senescent cells . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Experiments using the Cdk inhibitory proteins p 27 , p 18 , and p 19 proved that the activity of Cdk 2 , but not of Cdk 4 , was required for S phase entry mediated by E2F 1 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Protein levels of cell cycle control genes cyclin D 1 , cdk 2 , and E2F 1 are increased in these adenocarcinomas . c Fos protein levels are slightly increased in these cancers , while c Jun levels do not change . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Failure to inhibit E2F 1 activation of genes through its phosphorylation by the cyclin cdk 2 kinase has been shown to result in S phase arrest and apoptosis in a number of cell types . ^^^ Although exposure of the normal mammary cells to CD 437 does not result in modulation of cyclin A or cdk 2 levels , an increase in E2F 1 levels and a marked inhibition of cyclin A / cdk2 kinase activity are observed . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| In contrast , Cdk 2 inhibition was associated with increased Cdk 2 Tyr15 phosphorylation , increased E2F 1 recruitment , and decreased PCNA contents in Cdk 2 complexes . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| The data presented here indicate that , in vitro , NPDC 1 is able to interact with the transcription factor E2F 1 and some cell cycle proteins , such as D cyclins and cdk 2 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Expression of pRb , cyclin D 1 , cdk 4 , cyclin E , cdk 2 , E2F1 and DP 1 was determined in MCF 7 and MDA MB 468 breast carcinoma cells , H 460 and Calu 6 non small cell lung carcinoma cells , H 82 and SW 2 small cell lung carcinoma cells , HCT 116 and HT 29 colon carcinoma cells and LNCaP and DU 145 prostate carcinoma cells . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| The kinase activation was found to result from Tax induced expression of genes for cell cycle regulatory molecules including cyclin D 2 , cyclin E , E2F1 , CDK 2 , CDK 4 and CDK 6 , and Tax induced reduction of CDK inhibitors p 19 ( INK4d ) and p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Increased p 21 ( WAF 1 ) is associated with CDK 2 and CDK 4 . pRb is dephosphorylated in the presence of p 21 CDK2 / 4 complexes , and the Rb E2F1 complex increases after TPA treatment , whereas the Rb HDAC 1 complex decreases slightly . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical expression of cell cycle proteins E2F 1 , Cdk 2 , Cyclin E , p 27 ( kip 1 ) , and Ki 67 in normal placenta and gestational trophoblastic disease . ^^^ In this study we investigated the immunostaining patterns of G ( 1 ) restriction point and G ( 1 ) S regulatory proteins E2F 1 , Cdk 2 , cyclin E , p 27 ( kip 1 ) , and the proliferation marker Ki 67 on routinely processed sections of 29 hydatidiform moles ( 10 partial moles and 19 complete moles , including 9 persistent moles ) , 7 choriocarcinomas , and 7 normal placentas . ^^^ Abnormal trophoblastic proliferations may be mediated through interactions of Cdk 2 , E2F 1 , cyclin E , and p 27 ( kip 1 ) . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| No differences were observed between RA sensitive and RA resistant ovarian carcinoma cells in the levels of expression of many cell cycle genes including cyclin A , B and E , cdk 2 , 4 and 6 , E2F 1 , E2F 2 , E2F 3 , E2F 4 , E2F 5 , DP 1 and DP 2 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| The viral IE 86 protein induced a significant increase in the cellular steady state RNA level from the B myb , cyclin E , cdk 2 , E2F 1 , ribonucleotide reductase 1 , ribonucleotide reductase 2 , thymidylate synthetase , MCM 3 , and MCM 7 genes , but actin RNA was not affected . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Scatter factor / hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G ( 1 ) is c Myc dependent and independent of p 27 suppression , Cdk 2 activation , or E2F1 dependent transcription . ^^^ We conclude that SF / HGF prevents G ( 1 ) / G ( 0 ) arrest in glioma cell lines by a c myc dependent mechanism that is independent of p 27 , Cdk 2 , or E2F1 . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Overexpression of c myc , Cyclins D 1 , E , and A , and E2F1 genes , at messenger RNA ( mRNA ) and protein levels , rise in Cyclin D 1 CDK4 , Cyclin E CDK 2 , and E2F1 DP 1 complexes , and pRb hyperphosphorylation occurred in nodules and HCCs of F 344 rats . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| In terminally differentiated ( TD ) cells , the activation of Np 95 was specifically induced by E1A , but not by overexpression of E2F 1 or of the cyclin E ( cycE ) cyclin dependent kinase 2 ( cdk 2 ) complex . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Although cell cycle analyses were performed by means of computer assisted microscope analyses of Feulgen stained nuclei , the gastrin induced effects of the levels of expression of cyclins D 3 and E , CDK 2 , CDK 4 , CDK 5 , CDK 7 , p 15 , p 16 , E2F1 , and E2F2 were assayed by means of quantitative Western blot test . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| When CDK 2 activity was bypassed by activation of the ER E2F1 fusion protein , cAMP no longer inhibited expression of Cdc25A or cyclin A but still inhibited DNA synthesis . ^^^ Inhibition of Raf 1 and ERK1 / 2 activation may operate early in G ( 1 ) , but when this early block is bypassed by DeltaRaf 1 : ER , cells still fail to enter S phase due to inhibition of CDK 2 or targets downstream of E2F1 . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Collectively , these results establish that TNFalpha targets IGF 1 induced E2F 1 synthesis , leading to inhibition of the subsequent accumulation in cyclin A , formation of cyclin A Cdk 2 complexes , hyperphosphorylation of RB , and cell cycle arrest . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Cellular expression of Cdk 2 was increased in UMG 1 2 after etoposide treatment while the expression of E2F 1 in UMG 1 2 was decreased as compared with that in U373MG . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| To assess the cellular mechanisms underlying the mesangial cell proliferation and glomerulosclerosis in progressive human IgA nephropathy ( IgAN ) , we examined the expression of E2F1 , Rb , c Myc , proliferating cell nuclear antigen ( PCNA ) , cyclins ( D 1 , E and A ) , cyclin dependent kinase 2 ( CDK 2 ) and CDK inhibitors ( p 21 ( waf 1 ) , p 27 ( kip 1 ) , 57 ( kip 2 ) and p 16 ( ink4a ) ) by immunohistochemistry in renal biopsy specimens . ^^^ Increased apoptotic activity was identified in progressive glomerular lesions of advanced IgAN , which correlated with the proliferative activity in these lesions as assessed by total expression levels of PCNA and CDK 2 in glomeruli , E2F1 expression levels in the mesangium , cyclin D 1 expression levels in endothelium and the c Myc glomerular staining score . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Here we show that activation of the human E2F1 and cyclin dependent kinase 2 ( CDK 2 ) promoters requires elements from both the N and C terminal regions of LANA . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| We show that core protein suppresses the expression of tumor suppressor protein p 53 and cyclin dependent kinase ( CDK ) inhibitor p 21 and enhances the activation of cyclin dependent kinase 2 ( CDK 2 ) , the phosphorylation of retinoblastoma ( Rb ) , the activation of the transcription factor E2F 1 , and the expression of E2F 1 and S phase kinase interacting protein 2 ( SKP 2 ) genes . ^^^ Pretreatment of core protein expressing cells with the inhibitor of CDK 2 , Butyrolactone 1 , abolished the phosphorylation of Rb , the activation of E2F 1 , and inhibited the expression of E2F 1 gene and cell growth induced . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Over expression of E2F 1 , cyclin D 1 , Cdk 2 , Cdk 4 and cyclin A was found in 64 % ( 30 of 46 ) , 43 % ( 26 of 46 ) , 28 % ( 11 of 46 ) , 71 % ( 33 of 46 ) and 63 % ( 29 of 46 ) of HCCs examined respectively and this was correlated with elevation of ERK . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Activation of Cdk 2 pRB E2F1 cell cycle pathway by repeated electroconvulsive shock in the rat frontal cortex . ^^^ The activity of cyclin dependent kinase 2 ( Cdk 2 ) , phosphorylation , and total protein amount of cyclin D 1 , cyclin E , pocket retinoblastoma family of protein ( pRB ) , and E2F1 were analyzed in the rat cerebral cortex . ^^^ RESULTS : The activity of Cdk 2 , the protein amount of pRB , Ser 795 phosphorylation of pRB , and the protein amount of E2F1 were all increased compared with the sham treated control subjects , and these increases were enhanced with the increasing number of ECS . ^^^ CONCLUSIONS : The Cdk 2 pRB E2F1 cell cycle pathway is activated by repeated ECS in the rat frontal cortex . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis demonstrated that RhoA mediates induction of E2F 1 , Cdk 2 and PCNA , accompanying concurrent reduction in p 21 and p 27 . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| Detailed analysis of expression of selected genes in beta carotene treated LNCaP cells at the level of mRNA and protein indicated that the observed increase of proliferation could have been the result of slight induction of a few genes affecting proliferation ( c myc , c jun ) and apoptosis ( bcl 2 ) with no significant effect on major cell cycle control genes ( cdk 2 , RB , E2F 1 ) . . ^^^ |
|
| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| This amazing synergism was accompanied by synergistic modulation of E2F 1 and p 27 ( Kip 1 ) , which were reported to mediate the anticancer activities of lovastatin and troglitazone , respectively , and other cell cycle regulating proteins such as CDK 2 , cyclin A and RB phosphorylation status . ^^^ |
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| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| A negative feedback loop controlling oscillation is possible because activation of cdk 2 , following activation by cyclin E , phosphorylates the E2F 1 transcription factor , marking it for ubiquitination by the Skp 2 cullin F box complex and subsequent proteolytic removal . ^^^ |
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| Interacting proteins: Q01094 and P24941 |
Pubmed |
SVM Score :0.0 |
| The main targets of p 21 ( Waf 1 ) are Cyc 1E Cdk 2 and Cyc 1A Cdk 2 complexes , PCNA ( proliferating cell nuclear antigen ) , a subunit of DNA polymerase delta , and E2F 1 transcription factor . ^^^ |
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