| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.76166067 |
| Here , we demonstrate that E2F 1 may regulate the activity of the HIV 1 long terminal repeat through its ability to bind sequences in the NF kappaB enhancer region and to interact with the NF kappaB subunit , p 50 . 0.76166067^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| In an in vitro assay , these E2F1 Binding Proteins ( EBP 1 and EBP 2 ) associate with residues 1 121 of E2F1 or with the full length protein ; however , they do not associate with its carboxy terminus ( residues 88 437 ) . ^^^ When EBP 1 or EBP 2 were expressed in COS cells along with E2F1 and the target promoter DNA polymerase alpha , repression of transcription was observed . ^^^ However , no repression of DNA polymerase alpha was seen if the cells expressed a nonassociating mutant E2F1 ( residues 88 437 ) , along with EBP 1 or EBP 2 . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB p 50 and p 65 , AP 1 c Fos and c Jun , and E2F1 , and inhibits their transcriptional activity . p 202 also binds pRb , the retinoblastoma protein , and if overexpressed it retards cell proliferation . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Overexpression of p 202 in transfected cells retards cell proliferation . p 202 modulates the pattern of gene expression by inhibiting the activity of various transcription factors including NF kappaB , c Fos , c Jun , E2F 1 , and p 53 . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB ( p 50 and p 65 ) , AP 1 ( c Fos and c Jun ) , E2F 1 , E2F 4 , MyoD , and myogenin ) . p 202 modulates the transcriptional activity of these factors in transfected cells . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Ifi 202 encodes the p 202 protein whose overexpression is growth inhibitory and which can bind and inhibit the activity of numerous transcription factors including c Jun , c Fos , NF kappaB , E2F 1 , E2F 4 , MyoD , and myogenin . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| We show here that E2F 1 can induce apoptosis by a death receptor dependent mechanism , by downregulating TRAF 2 protein levels and inhibiting activation of antiapoptotic signals including NF kappa B . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Even 2 3 fold overexpression of p202a in cells retards proliferation . p202a was shown to modulate transcription by binding , and inhibiting the activity of several transcription factors including c Fos , c Jun , AP 2 , E2F1 , E2F4 , NF kappaB , MyoD , and myogenin . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| The overexpression of Ebp 1 in MCF 7 and AU 565 ( Rb ( + ) ) cells inhibited the activity of the E2F1 regulated cyclin E promoter . ^^^ Ebp 1 bound E2F1 indirectly via Rb in lysates of MCF 7 cells . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Taken together , these data suggest that E2F1 promotes DA evoked caspase 3 dependent neuronal apoptosis by a mechanism independent of gene transactivation , and this may possibly occur through inhibition of anti apoptotic genes including NF kappaB . . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| E2F1 and c Myc potentiate apoptosis through inhibition of NF kappaB activity that facilitates MnSOD mediated ROS elimination . ^^^ During serum deprivation , MnSOD mRNA was induced by NF kappaB in mock transfected NIH3T3 , while this induction was inhibited in NIH3T3 overexpressing c Myc or E2F1 . ^^^ In these clones , E2F1 inhibited NF kappaB activity by binding to its subunit p 65 in competition with a heterodimeric partner p 50 . ^^^ In addition to overexpressed E2F1 , endogenous E2F1 released from Rb was also found to inhibit NF kappaB activity in a cell cycle dependent manner by using E2F1 ( + / + ) and E2F1 ( / ) murine embryonic fibroblasts . ^^^ These results indicate that E2F1 promotes apoptosis by inhibiting NF kappaB activity . . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Hyperglycemia enhances VSMC proliferation with NF kappaB activation by angiotensin 2 and E2F 1 augmentation by growth factors . ^^^ These data indicate that hyperglycemia contributes to abnormal proliferation of VSMC by two mechanisms ; the induction of NF kappaB activation by Ang 2 , which facilitates transcription of certain growth factors , and the augmentation of E2F 1 in response to growth factors . . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Adhesion molecule expression and cell adhesion were reduced in E2F 1 transduced HAECs , associated with a marked decrease in phosphorylated IkappaB alpha , required for nuclear translocation of NF kappaB p 65 . ^^^ CONCLUSIONS : These findings suggest that E2F 1 stabilizes IkappaB and thereby may inhibit NF kappaB dependent processes involved in atherogenesis , including endothelial expression of E selectin , vascular cellular adhesion molecule 1 , and intracellular adhesion molecule 1 and cell adhesion to perturbed endothelial cells . . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| In addition , transcriptional derepression was observed in RNAi treated cells , indicating the ability of endogenous DAXX to repress gene expression and allowing for the identification of novel targets of DAXX repression , including nuclear factor kappaB ( NF kappaB ) and E2F1 regulated targets . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB , the c jun N terminal kinase c Jun pathway , p 53 , E2F1 , and other transcription factors are probably all involved in regulating the expression of BH 3 only proteins after brain ischaemia , and mitochondrial translocation of Bad from sequestering cytosolic proteins is promoted by inactivation of the serine threonine kinase , Akt . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Repression of E2F1 mediated transcription by the ErbB 3 binding protein Ebp 1 involves histone deacetylases . ^^^ Ebp 1 binds the tumor suppressor retinoblastoma protein ( Rb ) both in vivo and in vitro , and Rb and Ebp 1 cooperate to inhibit the transcription of the E2F1 regulated cyclin E promoter . ^^^ The Ebp 1 mediated transcriptional repression depended on the presence of an E2F1 consensus element in the promoters . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Nuclear translocation and transcriptional activity of NF kappaB was markedly attenuated in Ad E2F1 transduced VSMCs , whereas it remained active in similarly treated ECs when the cells were exposed to TNF alpha . ^^^ Furthermore , E2F1 potentiates VSMC death by blocking antiapoptotic signaling pathway through inhibition of NF kappaB activation . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Candidate molecules that mediate c Myc and E2F1 enhanced apoptosis include p14 / p19ARF , ornithine decarboxylase and lactate dehydrogenase A ( for c Myc ) as well as p14 / p19ARF , p 73 , Apaf 1 and caspase 3 ( for E2F1 ) . c Myc also activates the CD95 / Fas FADD mediated death signal . c Myc and E2F1 inhibit NF kappaB activities induced by TNFalpha or reactive oxygen species . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| In conclusion , these results demonstrate that UDCA inhibits E2F 1 transcriptional activation of hepatocyte apoptosis , thus modulating p 53 stabilization , NF kappaB degradation , and expression of Bcl 2 family members . . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| Whereas GST Ebp 1 alone failed to bind E2F1 promoter elements , Ebp 1 contained in nuclear lysates associated with E2F1 consensus sequences in the E2F1 promoter . ^^^ Endogenous Ebp 1 was recruited to the E2F1 promoter in vivo as demonstrated by chromatin immunoprecipitation assays . ^^^ Ebp 1 bound E2F consensus oligonucleotides in association with E2F1 , retinoblastoma protein , and HDAC 2 . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| The ErbB 3 binding protein Ebp 1 interacts with Sin3A to repress E2F1 and AR mediated transcription . ^^^ Ebp 1 inhibits transcription of E2F1 and androgen receptor regulated genes such as prostate specific antigen ( PSA ) through its interactions with histone deacetylases ( HDACs ) . ^^^ Chromatin immunoprecipitation ( ChIP ) and DNA affinity precipitation analysis demonstrated that Ebp 1 and Sin3A associate at the PSA and E2F1 promoters . ^^^ Functionally , Sin3A enhanced the ability of Ebp 1 to repress transcription of androgen receptor ( AR ) and E2F1 regulated genes . ^^^ |
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| Interacting proteins: Q01094 and P19838 |
Pubmed |
SVM Score :0.0 |
| TIP 60 is a tightly regulated transcriptional coregulator , acting in a large multiprotein complex for a range of transcription factors including androgen receptor , Myc , STAT 3 , NF kappaB , E2F1 and p 53 . ^^^ |
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