| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.84124568 |
| PARP 1 binds E2F 1 independently of its DNA binding and catalytic domains , and acts as a novel coactivator of E2F 1 mediated transcription during re entry of quiescent cells into S phase . 0.84124568^^^ Protein binding reactions and coimmunoprecipitation experiments with purified PARP 1 and E2F 1 , however , revealed that PARP 1 binds to E2F 1 in vitro . 0.77772927^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Poly ( ADP ribose ) polymerase upregulates E2F 1 promoter activity and DNA pol alpha expression during early S phase . ^^^ We have shown that depletion of poly ( ADP ribose ) polymerase ( PARP ) by antisense RNA expression downregulates pol alpha and E2F 1 expression during early S phase . ^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Roles of poly ( ADP ribosyl ) ation and PARP in apoptosis , DNA repair , genomic stability and functions of p 53 and E2F 1 . ^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| In addition , caspase 3 and poly ( ADP ribose ) polymerase apoptotic fragments were detected by 48 h after treatment with Ad E2F 1 . ^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Cell cycle analysis , poly ( ADP ribose ) polymerase ( PARP ) cleavage and analysis of cell morphology also revealed that coinfection with both Ad E2F 1 and Ad p 21 ( PCNA ) enhanced cellular apoptosis compared to either virus alone . ^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Depletion of PARP also prevented induction of the expression of the transcription factor E2F 1 , which positively regulates transcription of the DNA pol alpha and PCNA genes ; thus , PARP may be necessary for expression of these genes when quiescent cells are stimulated to proliferate . . ^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , there was no new expression of PCNA and DNA pol alpha , as well as the transcription factor E2F 1 in PARP antisense cells during entry into S phase , suggesting that PARP may play a role in the expression of these proteins , perhaps by interacting with a site in the promoters for these genes . . ^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Caspase 3 / CPP32 activation and PARP cleavage in response to E2F 1 overexpression , alone and in combination with roscovitine , implicate the caspase cascade in E2F 1 mediated apoptosis of gastric cancer cells . ^^^ |
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| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis was used to examine the expression of E2F 1 and Bcl 2 family member proteins and PARP cleavage . ^^^ Cell cycle analysis , PARP cleavage and changes in cell morphology supported apoptosis as the mechanism of cell death in response to E2F 1 . ^^^ |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|