| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| Analysis of the enzymatic cascade involved in the conjugation process reveals that the ubiquitin carrier protein E 2 F1 and its human homolog UbcH 5 , which target the tumor suppressor p 53 for degradation , are also involved in c Fos recognition . ^^^ |
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| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| Transcriptional factor E2F 1 as well as tumor suppressor p 53 have been shown to cause apoptosis independently in some types of human cancer cells when overexpressed . ^^^ |
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| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate a similar chromatin unfolding activity associated with the transactivation domains of E2F1 and tumor suppressor p 53 . ^^^ |
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| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^ |
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| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| E2F1 induced apoptosis occurs via multiple pathways , some of which induce stabilization and activation of the tumor suppressor p 53 . ^^^ |
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| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| The initiation of this TP 53 dependent G 1 phase arrest occurs despite the presence of substantial levels of cyclin D1 / CDK4 and cyclin E / CDK2 kinase activities , hyperphosphoryated RB , and active E2F1 . ^^^ |
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| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp 53 deficient mice . ^^^ E2f1 / ; Trp 53 / double knockout mice exhibited the elevated UVB induced apoptosis of E2f1 / alone , rather than the profound apoptosis defect seen in Trp 53 / mice , indicating that Trp 53 ( p 53 ) lies functionally upstream of E2f1 . ^^^ Transfecting E2F1 into E2f1 / ; Trp 53 / primary fibroblasts suppressed UVB induced apoptosis and this suppression was relieved by Trp 53 . ^^^ |
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| Interacting proteins: Q01094 and P04637 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : We determined the mRNA expression of p 1 ( INK4A ) , p 14 ( ARF ) , CDK 4 , RB 1 , MDM 2 , TP 53 , and E2F1 by quantitative reverse transcription PCR in 38 cases of GISTs and correlated the findings with clinicopathologic factors , including mutation analysis of KIT and PDGFRA . ^^^ GISTs with low mRNA expression of the CDKN2A transcripts p 16 ( INK4A ) and p 14 ( ARF ) but high mRNA expression of CDK 4 , RB 1 , MDM 2 , TP 53 , and E2F1 were associated with aggressive clinical behavior and unfavorable prognosis , whereas GISTs with a low mRNA expression of CDK 4 , RB 1 , MDM 2 , TP 53 , and E2F1 were not . ^^^ |
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