| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| In addition , overexpression of E2F 6 suppresses the transactivational effects of coexpression of E2F 1 and DP 1 . ^^^ |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| We found that depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters . ^^^ |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| H 19 repression by pRb and E2F6 confirms the E2F1 dependent control of the H 19 promoter . ^^^ |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Among the members of the E2F family , E2F1 to E2F4 , but not E2F5 or E2F6 , activated the JPO1 / CDCA7 reporter construct . ^^^ |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| RT PCR analyses revealed that the GCN 5 deficiency exhibited opposite influences on transcriptions of G1 / S phase transition related genes , i . e . repressions for E2F 1 , E2F 3 , E2F 4 , E2F 6 , DP 2 , cyclin A , cyclin D 3 , PCNA , cdc25B and p 107 ; and activations for p 27 , c myc , cyclin D 2 and cyclin G 1 . ^^^ |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| However , E2F is not a general regulator of oxidative phosphorylation genes since three additional nuclear encoded mitochondrial genes were unaffected by E2F1 or E2F6 . . ^^^ |
|
| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Levels of endogenous or ectopically expressed E2F1 , 2 , and 3 , but not E2F6 , were reduced after synthesis of p19ARF , through a mechanism involving increased turnover . p19ARF induced degradation of E2F1 depended on a functional proteasome , and E2F1 was relocalized to nucleoli when coexpressed with p19ARF . ^^^ |
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| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Based on current evidence in the field , mammalian E2Fs can be functionally categorized into either transcriptional activators ( E2F1 , E2F2 , and E2F3a ) or repressors ( E2F3b , E2F4 , E2F5 , E2F6 , and E2F7 ) . ^^^ |
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| Interacting proteins: O75461 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of E2F1 protein was found to increase E2F6 mRNA levels and significantly upregulate E2F6 promoter activity . ^^^ Deletion or mutation of the putative E2F binding sites nullified the effects of E2F1 on the E2F6 promoter activity . ^^^ Studies on the temporal induction of E2F family members demonstrated that the activating E2Fs , and most notably E2F1 , were upregulated before E2F6 during cell cycle progression at the G1 / S phase , and this coincided with the time course of induction experienced by the E2F6 promoter during the course of the cell cycle . ^^^ EMSAs indicated the specific binding of nuclear complexes to the E2F6 promoter that contained E2F1 related species whose binding was specifically competed by the consensus E2F binding site . ^^^ These data indicate that the expression of the E2F6 repressor is influenced at the transcriptional level by E2F family members and suggest that interplay among these transcriptional regulators , especially E2F1 , may be critical for cell cycle regulation . . ^^^ |
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