| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :1.2176548 |
| In an anchorage minus G ( 1 ) arrested rat fibroblast , only Cdk 6 D3 retains kinase activity due mainly to its ability to evade inhibition by p 27 ( KIP 1 ) and p 21 ( CIP 1 ) with a resemblance to viral cyclin bound Cdk 6 . 1.2176548^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.60286642 |
| Low levels of cyclin D and nonfunctional Rb protein affect cdk 6 association with cyclin dependent kinase inhibitor p 27 ( Kip 1 ) . p 27 ( Kip 1 ) associates with cyclin / cdk complexes and inhibiting cdk activity , and overexpression of p 27 ( Kip 1 ) induces G 1 arrest . 0.60286642^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we used the RNA alphavirus Sindbis to express three known cyclin dependent kinase inhibitors ( CKIs ) , p 16 ( ink 4 ) , p 21 ( waf / cip ) , and p 27 ( kip 1 ) , and dominant negative mutant forms of four known G 1 cyclin dependent kinases ( CDKs ) , Cdk 2 , Cdk 3 , Cdk 4 , and Cdk 6 , in primary cultured rat superior cervical ganglion sympathetic neurons . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| In these clones , binding of p 16 to cdk 4 and cdk 6 abrogated binding of cyclin D 1 , p 27 ( KIP 1 ) , and p 21 ( WAF1 / CIP1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| To understand the structural basis for the 5 cyclin specificity for CDK 6 and the insensitivity of the complex to inhibitors of the p 21 and INK 4 families , a 5 cyclin CDK 2 model was built on the basis of the known structures of human cyclin A in complex with CDK 2 and the CDK inhibitor p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The dissociation of p 21 ( CIP 1 ) and p 27 ( KIP 1 ) from their cdk complexes correlated well with the activation of cdk 2 , cdk 4 , and cdk 6 and the release from cell cycle arrest . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| We did not observe consistent changes in protein levels of cyclin D , cyclin E , CDK 4 , CDK 6 , CDK 2 , p 27 ( Kip 1 ) , p 16 ( INK4a ) , or RNA levels of p 15 ( INK4b ) . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Both p 21 ( Cip 1 ) and p 27 ( Kip 1 ) proteins were induced during erythroid differentiation , but only p 27 ( Kip 1 ) associated with the principal G ( 1 ) CDKs cdk 4 , cdk 6 , and cdk 2 . ^^^ The kinetics of binding of p 27 ( Kip 1 ) to CDK complexes was distinct in that p 27 ( Kip 1 ) associated primarily with cdk 4 ( and , to a lesser extent , cdk 6 ) early in differentiation , followed by subsequent association with cdk 2 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| We found that the expression of cyclin A and p 21 ( WAF 1 ) molecules was primarily modulated by TGFbeta 1 treatment while the expression of other regulatory components , like cyclins D , cyclin E , cdk 2 , cdk 4 , and cdk 6 or p 15 ( INK4B ) , p 16 ( INK4A ) , and p 27 ( KIP 1 ) was not significantly affected . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The kinase activation was found to result from Tax induced expression of genes for cell cycle regulatory molecules including cyclin D 2 , cyclin E , E2F1 , CDK 2 , CDK 4 and CDK 6 , and Tax induced reduction of CDK inhibitors p 19 ( INK4d ) and p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Induction of G 1 cell cycle arrest was also observed in PC 3 cells treated with I3C , which may be due to the observed effects of I3C in the up regulation of p 21 ( WAF 1 ) and p 27 ( Kip 1 ) CDK inhibitors , followed by their association with cyclin D 1 and E and down regulation of CDK 6 protein kinase levels and activity . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Following IL 6 treatment of LNCaP , Western blot analysis showed that the protein levels of cyclin dependent kinase 2 ( CDK 2 ) , CDK 4 , and CDK 6 were decreased , while accumulation of CDK inhibitor p 27 ( Kip 1 ) was rapidly and markedly induced . ^^^ Further , a significant amount of p 27 ( Kip 1 ) was co precipitated with CDK 2 , CDK 4 and CDK 6 , as detected in immunoprecipitation experiments . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The main effect of the ectopic Cdk 6 expression was to sequester TGF beta induced p 15 ( Ink4b ) and to maintain more p 27 ( Kip 1 ) in cyclin D complexes preventing the complete shift of p 27 ( Kip 1 ) to Cdk 2 invoked by TGF beta . ^^^ This led to the presence of an active cyclinD Cdk 6 p27 ( Kip 1 ) complex and partially active cyclin E Cdk 2 complex and resulted in the failure of TGF beta to fully arrest Mv1Lu cell growth . ^^^ Though dominant negative Cdk 6 , expressed similarly in the cells , sequestered both p 15 ( Ink4b ) and p 27 ( Kip 1 ) , it lacks kinase activity and was unable to override the TGF beta arrest . ^^^ The results demonstrate that downregulation of Cdk 6 kinase is required for the enforcement of the G ( 1 ) phase arrest by TGF beta and results in changes in association of the p 15 ( Ink4b ) and p 27 ( Kip 1 ) inhibitors with D and E type cyclin kinase complexes . . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| A particular role in the regulation of these phenomena is played by proteins involved in early G 1 phase regulation : pRb kinases : cyclin dependent kinases ( cdk ) : cdk 4 and cdk 6 activated by cyclins D , and universal cdk inhibitor p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| We show that this effect was mediated through the up regulation of cdk 6 and cyclins D 1 and E , and enhanced degradation and relocalization of p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Ectopic overexpression of Jak 3 in 32Dcl3 cells resulted in an acceleration of the G CSF induced differentiation program that was preceded by G ( 1 ) cell cycle arrest , which was associated with the up regulation of the cyclin dependent kinase inhibitor p 27 ( Kip 1 ) and down regulation of Cdk 2 , Cdk 4 , Cdk 6 , and Cyclin E . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Downregulation of the kinase activities is mediated by induction of cyclin dependent kinase ( CDK ) inhibitor p 15 ( Ink4b ) which blocks CDK 4 and CDK 6 kinases and leads to binding of p 27 ( Kip 1 ) to CDK 2 cyclin E complex . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| We found that ROCK blockade decreased expression of cell cycle proteins , cyclin D 3 , CDK 6 , and p 27 ( KIP 1 ) in the hearts and cardiomyocytes , which are required for initiation of cell cycle and G1 / S phase transition . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Further analysis indicated that , in the quiescent cells , p 18 ( INK4c ) is found in increasing association with CDK 6 , whereas p 27 ( Kip 1 ) associates predominantly with CDK 2 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| In rasREF cells treated with DE for 72 h in suspension culture ( a ) , the levels of cyclin D 1 , cyclin A , p 27 ( Kip 1 ) , and hyperphosphorylated Rb were decreased , but the levels of cdk 4 , cdk 6 , cdk 2 , p 16 ( INK4a ) , and p 21 ( Cip 1 ) were not affected . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| While the amounts of the cellular cyclin dependent kinase ( Cdk ) inhibitors p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , and p 16 ( INK4a ) did not change in infected cells , MHV infection in asynchronous cultures induced a clear reduction in the amounts of Cdk 4 and G ( 1 ) cyclins ( cyclins D 1 , D 2 , D 3 , and E ) in both DBT and 17Cl 1 cells and a reduction in Cdk 6 levels in 17Cl 1 cells . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Moreover , we show that 5 cyclin and cyclin dependent kinase 6 ( CDK 6 ) form an active kinase without p 27 ( KIP 1 ) and that CDK 6 is the in vivo catalytic subunit of 5 cyclin in PEL cells . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Moreover , ZD 1839 increased the protein levels of p 27 ( KIP 1 ) and retinoblastoma related Rb2 / p130 while decreased the expression of cyclin dependent kinase 2 ( CDK 2 ) , CDK 4 , CDK 6 and cyclin D 1 , cyclin D 3 . ^^^ Our results indicate that downregulation of the expression and function of CDK 2 , CDK 4 , CDK 6 , cyclin D 1 and cyclin D 3 , as well as upregulation of p 27 ( KIP 1 ) and pRb2 / p130 , are strong candidates for the cell cycle regulator that arrests ZD 1839 treated A 549 cells at G 1 phase . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Furthermore , DIM downregulated the expression of cyclin dependent kinases 2 and 6 ( CDK 2 , CDK 6 ) , and upregulated the expression of CDK inhibitor , p 27 ( Kip 1 ) , in HUVECs . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Among all D type cyclin / cdk4 and cdk 6 complexes , cyclin D3 / cdk4 is most active in sequestering the inhibitory activity of p 27 ( kip 1 ) in vitro in a cyclinE / cdk2 kinase assay . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Furthermore , although both p 21 ( Cip 1 ) and p 27 ( Kip 1 ) associated with Cdk 6 , only p 27 ( Kip 1 ) significantly inhibited its activity . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that 5 cyclin together with its kinase partner CDK 6 phosphorylates the associated p 27 ( KIP 1 ) in PEL cells , which represent a biologically relevant model system for KSHV pathobiology . ^^^ During latent viral replication p 27 ( KIP 1 ) was phosphorylated by 5 cyclin CDK 6 predominantly on Ser 10 , which enhances its cytoplasmic localization . ^^^ Interestingly , upon reactivation of KSHV lytic cycle , 5 cyclin CDK 6 phosphorylated p 27 ( KIP 1 ) on Thr 187 , which resulted in down regulation of p 27 ( KIP 1 ) protein levels . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| By contrast , cyclin D 2 and cdk 6 are coordinately increased , thereby overriding the inhibition by cdk inhibitors p 18 ( INK4c ) and p 27 ( Kip 1 ) and phosphorylating Rb in conjunction with the existing cdk 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical stains were carried out on tissue microarrays to evaluate the expression of proteins involved in the G ( 1 ) S transition and proteins that regulate apoptosis including Rb , E2F1 , cyclin D 1 , CDK 4 , CDK 6 , p 27 ( KIP 1 ) , p 21 ( WAF1 / CIP1 ) , p 53 , Mdm 2 , Bcl 2 , and Bax . ^^^ The positive phenotypes identified were as follows : Rb , 39 . 1 % ; E2F1 , 69 . 6 % ; cyclin D 1 , 30 . 4 % ; CDK 4 , 100 % ; CDK 6 , 30 . 4 % ; 39 . 1 % ; p 27 ( KIP 1 ) , 47 . 8 % ; p 21 ( WAF1 / CIP1 ) , 39 . 1 % ; p 53 , 43 . 5 % ; Mdm 2 , 17 . 4 % ; Bcl 2 , 91 . 3 % ; and Bax , 100 % . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the representative members of both families of CDK inhibitors , p21waf1 , cip 1 , p27kip1 , and p 18 , can prevent the phosphorylation of their CDK partners , CDK 2 and CDK 6 , by CDK activating kinase . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Proliferating Mv1Lu mink lung epithelial cells and human keratinocytes contain high levels of the universal Cdk inhibitor p27Kip1 distributed in complexes with Cdk 2 , Cdk 4 , and Cdk 6 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Chromosomal mapping of members of the cdc 2 family of protein kinases , cdk 3 , cdk 6 , PISSLRE , and PITALRE , and a cdk inhibitor , p27Kip1 , to regions involved in human cancer . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| In murine C2C12 myoblast cells , G 1 CDK enzymes ( CDK 2 , CDK 4 , and CDK 6 ) associate with four CDK inhibitors : p18INK4c , p19INK4d , p 21 , and p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The increased p27Kip1 bound preferentially to CDK 6 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The decline in the expression of p27Kip1 and sequestering of the inhibitory protein by cdk 4 and cdk 6 correlated with the increase in cdk 2 kinase activity during the G 1 phase . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Analysis of expression of genes regulating Rb phosphorylation revealed that activin A suppressed cyclin D 2 , the sole D type cyclin gene expressed in the hybridoma cells , and activated p21CIP1 / WAF1 but had no effect on expression of cyclin dependent kinases ( CDK 2 , CDK 4 , CDK 6 ) and other CDK inhibitors ( p27KIP1 , p16INK4a , p15INK4b ) . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Both viral cyclins form active kinase complexes with Cdk 6 that are resistant to inhibition by the CDK inhibitors p 16 ( Ink4a ) , p21Cip1 and p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The Rb cyclin D pathway was analyzed by studying the pRb protein , the p16MTS1 gene , cyclin D 1 , cyclin D 3 , p27Kip1 , cdk 4 , and cdk 6 proteins . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation experiments revealed that p27Kip1 protein associates with Cdk 2 and Cdk 4 , but not with Cdk 6 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The resulting growth inhibitory effect of HMBA was completely reversible and was analyzed in terms of percent cells in G 1 ; association of D type cyclins with cyclin dependent kinase ( cdk ) 4 and cdk 6 ; G 1 kinase activity ; association of retinoblastoma protein ( pRb ) and phosphorylated pRb with D type cyclins ; and association of p16INK4a , p15INK4b , and p27Kip1 with cdk 4 and cdk 6 . ^^^ At 5 h , treated cells showed a fivefold increase in cdk 4 associated p27Kip1 and , at 9 h , a fourfold increase in cdk 6 associated p27Kip1 over control levels . ^^^ The data suggest that HMBA induced growth inhibition is due to multifactorial mechanisms involving decreases in total cyclin D 1 and inhibition of cdk 4 and cdk 6 kinase activities through elevation of levels of cdk 4 and cdk 6 associated p27Kip1 and concomitant increases in hypophosphorylated pRb and stable cyclin D2 / pRb and cyclin D3 / pRb complexes that help maintain pRb in a functional state . . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Overall , these results demonstrate that RA treatment of EBV immortalized B lymphocytes is associated with multiple effects on G 1 regulatory proteins , including p27Kip1 up regulation , decreased levels of cyclins D 2 , D 3 and A , and inhibition of CDK 2 , CDK 4 and CDK 6 activity , which ultimately result in reduced pRb phosphorylation and G0 / G1 growth arrest . . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The growth inhibition of OVCA 420 cells by mAb C 225 or 4D5 was associated with an increased G 1 cell population ; an increased level of a cyclin dependent kinase ( CDK ) inhibitor p27Kip1 with increased association of p27kip1 with CDK 2 , CDK 4 and CDK 6 ; and decreased activities of these CDKs . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Cyclin / cyclin dependent kinase ( CDK ) complexes immunoprecipitated with p27Kip1 are differentially modified by DXM addition : ( a ) G 1 kinasic complexes ( cyclin D / CDK4 or CDK 6 ) associated with p27Kip1 are strongly decreased by DXM , ( b ) S phase complexes ( CDK2 / cyclin E and A ) remained stable or increased , and ( c ) the association of p27Kip1 with the phosphorylated forms of CDK 1 is increased by DXM . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Compatible with the effects on the cell cycle , treatment with mAb ID 5 decreased levels of cyclin dependent kinase ( CDK ) 2 , cyclin E , and CDK 6 proteins and reduced cyclin E CDK 2 associated kinase activity ; mAb HD 5 treated cells had increased p27Kip1 expression and an increased association of p27Kip1 with CDK 2 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The molecular events that lead to melanoma cell autonomous growth are not well defined , but are likely to include sustained activity of cyclin dependent kinases ( CDK 2 , CDK 4 and CDK 6 ) as a result of loss of CDK inhibitors ( such as p16INK4a and possibly p27KIP1 ) , and persistent upregulation of several cyclins ( cyclin D 1 , cyclin A and cyclin E ) , the positive regulators of CDKs . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The oncogenic role of reduced , but not absent , levels of p27KIP1 is supported by recent studies in murine models and evidence that this protein not only inhibits the activity of complexes containing CDK 2 and cyclin E , but also promotes the assembly and catalytic activity of CDK 4 or CDK 6 in complexes with cyclin D . . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| A vitamin D 3 analog induces a G 1 phase arrest in CaCo 2 cells by inhibiting cdk 2 and cdk 6 : roles of cyclin E , p21Waf1 , and p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| In contrast , oncogenic Ras mediated nuclearto cytoplasmic mislocalization of p27KiP1 ( p 27 ) and of the cyclin dependent kinase ( CDK ) CDK 6 , but not CDK 2 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Cyclin K resists the actions of the p 16 INK4a and p27Kip1 inhibitors and extends the range of cdk 6 substrates , thereby inducing cell cycle progression toward S phase . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Naive cells are in a classical state of G0 / G1 arrest , with high expression of p27Kip1 and low CDK 6 and CDK 2 kinase activity . ^^^ In contrast , memory cells have low expression of p27Kip1 and high CDK 6 kinase activity . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| End stage differentiation of neutrophil granulocytes in vivo is accompanied by up regulation of p27kip1 and down regulation of CDK 2 , CDK 4 , and CDK 6 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| METHODS : We used immunoprecipitation with K cyclin antibodies to examine the association of K cyclin with cdk 2 , cdk 6 , p21Cip1 , and p27Kip1 proteins in BC 3 cells . ^^^ RESULTS : Viral K cyclin interacted with cyclin dependent kinases cdk 2 , cdk 4 , and cdk 6 and with the cyclin / cdk inhibitory proteins p21Cip1 and p27Kip1 in BC 3 cell lysates . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| K cyclin encoded by Kaposi ' s sarcoma associated herpesvirus confers resistance to the cyclin dependent kinase ( cdk ) inhibitors p16Ink4A , p21Cip1 , and p27Kip1 on the associated cdk 6 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Some important cell cycle regulators were reduced in rho 0 cells : cyclin D 3 , cdk 6 , p18INK4C , p27KIP1 , and p21CIP1 / WAF1 . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Early onset of G 1 cell cycle arrest along with upregulation of the cyclin dependent kinase inhibitor p27Kip1 and downregulation of Cdk 2 , Cdk 4 , Cdk 6 , and Cyclin E has also been observed in Jak 3 overexpressing 32Dcl3 cells . ^^^ |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|