| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the representative members of both families of CDK inhibitors , p21waf1 , cip 1 , p27kip1 , and p 18 , can prevent the phosphorylation of their CDK partners , CDK 2 and CDK 6 , by CDK activating kinase . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| In the glioblastomas with no alterations of CDKN2A , CDK 4 or RB 1 , several other genes ( CCND 1 , CCND 2 , CCND 3 , CDK 6 , E2F , CDK 7 , MYC and MYCN ) whose products take part in cell cycle regulation were examined . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| Furthermore , p18Ink4c inhibits CDK 6 phosphorylation and activation by CAK . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| The present study was undertaken to explore the expression and regulation of six additional members of the Cdk family ( Cdk 2 , Cdk 3 , Cdk 4 , Cdk 6 , Cdk 7 and Cdk 8 ) during lens differentiation . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| However , RA had no effect on the levels of cyclins A , D 1 , D 3 , E , or H , or on Cdk 2 , Cdk 4 , Cdk 5 , CDk 6 , Cdk 7 , p 16 ( Ink4A ) , p 15 ( Ink4B ) , p 53 , or pRb proteins in CH 27 cells . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| Enzymatic activities of cyclin D 1 , E , A , Cdk 4 , Cdk 6 , Cdc 2 , Cdk 7 , and Wee 1 kinase were measured by in gel kinase assay . ^^^ Cdk 6 and Cdk 7 activities remained unchanged in the process from normal liver to HCC . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| CAK independent activation of CDK 6 by a viral cyclin . ^^^ We find that KSHV cyclin can activate CDK 6 independent of phosphorylation by CAK in vitro . ^^^ In cells , expression of CDK 6 or to a lesser degree of a nonphosphorylatable CDK 6 ( T177A ) together with KSHV cyclin induced apoptosis , indicating that CDK 6 activation by KSHV cyclin can proceed in the absence of phosphorylation by CAK in vivo . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| The protein levels of cyclins D 1 , E , A , and H , and of cyclin dependent kinase 1 ( Cdk 1 ) , Cdk 2 , Cdk 4 , Cdk 6 , and Cdk 7 in HCC and in surrounding nontumorous cirrhosis were determined by Western blot . ^^^ The enzymatic activities of cyclins D 1 , E , A , Cdk 1 , Cdk 4 , Cdk 6 , Cdk 7 , and Wee 1 were measured using in vitro kinase assays . ^^^ The kinase activities of Cdk 6 , Cdk 7 , and Cdk 1 did not differ between HCC and surrounding cirrhotic tissues . ^^^ |
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| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| Activation of Cdk 6 by the D type cyclins requires phosphorylation of Cdk 6 by CAK on threonine 177 . ^^^ In contrast , Cdk 6 is activated by the Kaposi ' s sarcoma associated herpesvirus ( KSHV ) cyclin in the absence and presence of CAK phosphorylation . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| The Cyclin dependent kinase ( CDK ) Activating Kinase ( CAK ) is responsible for the activating phosphorylation of CDK 1 , CDK 2 , CDK 4 and CDK 6 and regulation of the cell cycle . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| Among them , compound 20 displayed high inhibitory potency at CDK 1 ( IC ( 50 ) = 0 . 021 microM ) , CDK 2 , and CDK 5 and submicromolar potency at CDK 4 , CDK 6 , and CDK 7 . ^^^ |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P50613 |
Pubmed |
SVM Score :0.0 |
| NA |
|