| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.51795406 |
| In p18INK4C positive HCCs , p18INK4C dominantly interacted with Cdk 4 rather than with Cdk 6 . pRb phosphorylated at serine ( Ser ) 780 was detected more frequently in p18INK4C negative than in p18INK4C positive HCCs . 0.51795406^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The four members of the INK 4 gene family , p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) , are known to bind to and inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G1 / S transition in the cell division cycle . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The four members of the INK 4 gene family ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) ) inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G 1 > S transition in the cell division cycle . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The INK 4 family of cyclin dependent kinase ( CDK ) inhibitors includes four 15 to 19 kDa polypeptides ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) , and p 19 ( INK4d ) ) that bind to CDK 4 and CDK 6 . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| However , an increase in the expression of the Cdk4 / 6 inhibitor p 18 ( INK4c ) and its extensive association with Cdk 4 and Cdk 6 were apparent following progestin treatment . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Here we present the 2 . 9 A crystal structure of the inactive ternary complex between Cdk 6 , the INK 4 inhibitor p 18 ( INK4c ) , and a D type viral cyclin . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| In activated T cells , p 18 ( INK4c ) remained constant , and preferentially associated with and inhibited CDK 6 but not CDK 4 . ^^^ We propose that p 18 ( INK4c ) sets an inhibitory threshold in T cells and one function of CD 28 costimulation is to counteract the p 18 ( INK4c ) inhibitory activity on CDK 6 cyclin D complexes . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The novel link between cell cycle control and plasma cell differentiation may , at least in part , relate to p 18 ( INK4c ) inhibition of CDK 6 . ^^^ |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Further analysis indicated that , in the quiescent cells , p 18 ( INK4c ) is found in increasing association with CDK 6 , whereas p 27 ( Kip 1 ) associates predominantly with CDK 2 . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| By contrast , cyclin D 2 and cdk 6 are coordinately increased , thereby overriding the inhibition by cdk inhibitors p 18 ( INK4c ) and p 27 ( Kip 1 ) and phosphorylating Rb in conjunction with the existing cdk 4 . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Progression through the G 1 phase of the cell cycle is dependent on the activity of holoenzymes formed between D type cyclins and their catalytic partners , the cyclin dependent kinases cdk 4 and cdk 6 . p16INK4a , p15INK4b , and p18INK4c , a group of structurally related proteins , function as specific inhibitors of the cyclin D dependent kinases and are likely to play physiologic roles as specific regulators of these kinases in vivo . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The first group , including p16Ink4a , p15Ink4b , p18Ink4c and p19Ink4d , is specific for the G 1 CDKs , CDK 4 and CDK 6 , inhibiting the kinase activity of cyclin D / CDK4 CDK 6 complexes on pRb . p16Ink4a , down regulated by pRb , inhibits G 1 CDKs by competition with cyclin D ; p15Ink4b , the synthesis of which is induced by TGF beta , seems to be a mediator of TGF beta mediated cell cycle arrest . ^^^ Furthermore , p18Ink4c inhibits CDK 6 phosphorylation and activation by CAK . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Induction of p18INK4c and its predominant association with CDK 4 and CDK 6 during myogenic differentiation . ^^^ In murine C2C12 myoblast cells , G 1 CDK enzymes ( CDK 2 , CDK 4 , and CDK 6 ) associate with four CDK inhibitors : p18INK4c , p19INK4d , p 21 , and p27Kip1 . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The cdk 6 specific inhibitor p18ink4C is expressed and associated with cdk 6 in all five squamous cell carcinoma lines . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization of mouse embryo sections demonstrated expression of mRNAs encoding two polypeptide inhibitors ( p18INK4c and p19INK4d ) of cyclin D dependent kinase ( CDK ) 4 and CDK 6 in the central nervous system . ^^^ The p19INK4d and p18INK4c proteins formed complexes with either CDK 4 or CDK 6 in a temporal pattern consistent with the results of in situ hybridization . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| The p18INK4c protein , a member of the p16 / INK4 cyclin dependent kinase ( CDK ) inhibitor family , is induced more than 50 fold during myogenic differentiation of mouse C2C12 myoblasts to become the predominant CDK inhibitor complexed with CDK 4 and CDK 6 in terminally differentiated myotubes . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin dependent kinase ( CDK ) 4 and CDK 6 . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Specifically , 18 genes were present in both signatures , including genes that code for cell cycle regulatory proteins ( cyclin A 2 , cyclin D 3 , cyclin H , CDK 6 , p18INK4c , p21Cip1 , PAK 1 ) and centrosome associated proteins ( pericentrin , alpha 2 tubulin , NUMA 1 , TUBGCP 2 , PRKAR2A ) . ^^^ |
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| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| Some important cell cycle regulators were reduced in rho 0 cells : cyclin D 3 , cdk 6 , p18INK4C , p27KIP1 , and p21CIP1 / WAF1 . ^^^ |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q00534 |
Pubmed |
SVM Score :0.0 |
| NA |
|