| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :1.2176548 |
| In an anchorage minus G ( 1 ) arrested rat fibroblast , only Cdk 6 D3 retains kinase activity due mainly to its ability to evade inhibition by p 27 ( KIP 1 ) and p 21 ( CIP 1 ) with a resemblance to viral cyclin bound Cdk 6 . 1.2176548^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the representative members of both families of CDK inhibitors , p21waf1 , cip 1 , p27kip1 , and p 18 , can prevent the phosphorylation of their CDK partners , CDK 2 and CDK 6 , by CDK activating kinase . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Both viral cyclins form active kinase complexes with Cdk 6 that are resistant to inhibition by the CDK inhibitors p 16 ( Ink4a ) , p21Cip1 and p27Kip1 . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Likewise , cyclin D is complexed with its catalytic partners CDK 4 and CDK 6 in senescent HDF , but it is not known whether these complexes are active . p21Sdi1 , Cip 1 , Waf 1 , a ubiquitous inhibitor of the activity of cyclin CDK complexes , increases progressively throughout the life span of HDF , but then declines again after the cells become senescent . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Induction of p19ARF activated p 53 by increasing its stability , and allowed the expression of p21Cip1 , which bound to all of the cyclin D 1 cdk complexes ( cyclin D 1 cdk2 , cdk 4 , and cdk 6 ) thereby inhibiting their kinase activities . p19ARF formed complexes with several cellular proteins including mouse MDM 2 . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| The dissociation of p 21 ( CIP 1 ) and p 27 ( KIP 1 ) from their cdk complexes correlated well with the activation of cdk 2 , cdk 4 , and cdk 6 and the release from cell cycle arrest . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| There was no effect on p 21 ( Cip 1 ) , cyclin D 2 , cdk 4 , and cdk 6 . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Both p 21 ( Cip 1 ) and p 27 ( Kip 1 ) proteins were induced during erythroid differentiation , but only p 27 ( Kip 1 ) associated with the principal G ( 1 ) CDKs cdk 4 , cdk 6 , and cdk 2 . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| We found that the expression of cyclin A and p 21 ( WAF 1 ) molecules was primarily modulated by TGFbeta 1 treatment while the expression of other regulatory components , like cyclins D , cyclin E , cdk 2 , cdk 4 , and cdk 6 or p 15 ( INK4B ) , p 16 ( INK4A ) , and p 27 ( KIP 1 ) was not significantly affected . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Induction of G 1 cell cycle arrest was also observed in PC 3 cells treated with I3C , which may be due to the observed effects of I3C in the up regulation of p 21 ( WAF 1 ) and p 27 ( Kip 1 ) CDK inhibitors , followed by their association with cyclin D 1 and E and down regulation of CDK 6 protein kinase levels and activity . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| The amount of p16INK4A , p21CIP1 , p18INKAC and CDK 6 was variable from one cell line to the other . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| TGFbeta 1 induced growth arrest was associated with notably increased binding of p 21 ( WAF 1 ) to cdk 4 and cdk 6 . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Specifically , 18 genes were present in both signatures , including genes that code for cell cycle regulatory proteins ( cyclin A 2 , cyclin D 3 , cyclin H , CDK 6 , p18INK4c , p21Cip1 , PAK 1 ) and centrosome associated proteins ( pericentrin , alpha 2 tubulin , NUMA 1 , TUBGCP 2 , PRKAR2A ) . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| In rasREF cells treated with DE for 72 h in suspension culture ( a ) , the levels of cyclin D 1 , cyclin A , p 27 ( Kip 1 ) , and hyperphosphorylated Rb were decreased , but the levels of cdk 4 , cdk 6 , cdk 2 , p 16 ( INK4a ) , and p 21 ( Cip 1 ) were not affected . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| While the amounts of the cellular cyclin dependent kinase ( Cdk ) inhibitors p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , and p 16 ( INK4a ) did not change in infected cells , MHV infection in asynchronous cultures induced a clear reduction in the amounts of Cdk 4 and G ( 1 ) cyclins ( cyclins D 1 , D 2 , D 3 , and E ) in both DBT and 17Cl 1 cells and a reduction in Cdk 6 levels in 17Cl 1 cells . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| The levels of expression of G1 / S phase related proteins , such as cyclin D 1 , cyclin dependent kinase ( cdk ) 4 , cdk 6 , and proliferating cell nuclear antigen , were reduced and a cdk inhibitor , p 21 ( Cip 1 ) , was induced in rPCT 1 CM treated TR iBRB 2 cells . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| Furthermore , although both p 21 ( Cip 1 ) and p 27 ( Kip 1 ) associated with Cdk 6 , only p 27 ( Kip 1 ) significantly inhibited its activity . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| METHODS : We used immunoprecipitation with K cyclin antibodies to examine the association of K cyclin with cdk 2 , cdk 6 , p21Cip1 , and p27Kip1 proteins in BC 3 cells . ^^^ RESULTS : Viral K cyclin interacted with cyclin dependent kinases cdk 2 , cdk 4 , and cdk 6 and with the cyclin / cdk inhibitory proteins p21Cip1 and p27Kip1 in BC 3 cell lysates . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| K cyclin encoded by Kaposi ' s sarcoma associated herpesvirus confers resistance to the cyclin dependent kinase ( cdk ) inhibitors p16Ink4A , p21Cip1 , and p27Kip1 on the associated cdk 6 . ^^^ Thus , expression of the viral cyclin enables cells to subvert the cell cycle inhibitory function of p21Cip1 by promoting cdk 6 dependent phosphorylation of this antiproliferative protein . . ^^^ |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|