| Interacting proteins: Q00534 and P10275 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis confirmed the expected CDK 6 protein size ( 40 kd ) . ^^^ |
|
| Interacting proteins: Q00534 and P10275 |
Pubmed |
SVM Score :0.0 |
| The protein levels of cdk 2 , cdk 4 , and cdk 6 were not altered in HL60AR cells , whereas the activities of both ckd 2 and cdk 6 were higher in AR than in PT cells . ^^^ |
|
| Interacting proteins: Q00534 and P10275 |
Pubmed |
SVM Score :0.0 |
| The present study indicates that , in human prostate cancer cells , CDK 6 can also bind to the androgen receptor ( AR ) and stimulate its transcriptional activity in the presence of dihydrotestosterone . ^^^ The T877A mutant of the AR frequently found in advanced cases of prostate cancer displays an exaggerated stimulation of transcriptional activity by CDK 6 . ^^^ CDK 6 is present in the chromatin structure of these cells in association with the AR and the promoter region of the prostate specific antigen gene . ^^^ These findings suggest that CDK 6 may play an important role in the development and / or progression of a subset of human prostate cancers by stimulating the activity of the AR . . ^^^ |
|
| Interacting proteins: Q00534 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00534 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|