Interacting proteins: Q9Y5B0 and Q00403 |
Pubmed |
SVM Score :0.0 |
Solution structure of the carboxyl terminal domain of RAP 74 and NMR characterization of the FCP 1 binding sites of RAP 74 and human TFIIB . ^^^ The phosphatase activity of FCP 1 is strongly enhanced by the carboxyl terminal domain of RAP 74 ( cterRAP 74 , residues 436 517 ) , and this stimulatory effect of TFIIF can be blocked by TFIIB . ^^^ It has been shown that cterRAP 74 and the core domain of hTFIIB ( TFIIBc , residues 112 316 ) directly interact with the carboxyl terminal domain of hFCP 1 ( cterFCP , residues 879 961 ) , and these interactions may be responsible for the regulatory activities of TFIIF and TFIIB on FCP 1 . ^^^ These results provide new information about the recognition of acidic rich activation domains involved in transcriptional regulation , and provide insights into how TFIIF and TFIIB regulate the FCP 1 phosphatase activity in vivo . . ^^^ |
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Interacting proteins: Q9Y5B0 and Q00403 |
Pubmed |
SVM Score :0.0 |
Double affinity chromatography allowed for the simple and efficient isolation of a complex containing all 12 RNAPII subunits , the general transcription factors TFIIB and TFIIF , the RNAPII phosphatase Fcp 1 , and a novel 153 kDa polypeptide of unknown function that we named RNAPII associated protein 1 ( RPAP 1 ) . ^^^ |
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Interacting proteins: Q9Y5B0 and Q00403 |
Pubmed |
SVM Score :0.0 |
FCP 1 , a phosphatase specific for the carboxyl terminal domain of the largest subunit of RNA polymerase 2 , is regulated by the HIV 1 Tat protein , CK 2 , TFIIB , and the large subunit of TFIIF ( RAP 74 ) . ^^^ |
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Interacting proteins: Q9Y5B0 and Q00403 |
Pubmed |
SVM Score :0.0 |
FCP 1 activity has been shown to be regulated by the general transcription factors TFIIF ( RAP 74 ) and TFIIB , protein kinase CK 2 ( CK 2 ) , and the HIV 1 transcriptional activator Tat . ^^^ |
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Interacting proteins: Q9Y5B0 and Q00403 |
Pubmed |
SVM Score :0.0 |
NA |
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