| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| The distribution of three components of basement membranes ( BM ) : heparan sulfate proteoglycan ( HSPG ) , entactin ( ENT ) , and type 4 collagen ( Coll . 4 ) , was studied in the adult rat anterior pituitary and compared to the distribution of laminin ( LAM ) described in an earlier report ( Vila Porcile et al . , 1987 , J . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| The distribution of four basement membrane components : laminin ( LAM ) , type 4 collagen ( Coll . 4 ) , heparan sulfate proteoglycan ( HSPG ) , and entactin ( ENT ) , was studied by immunocytochemistry in primary cultures of adult rat anterior pituitaries . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Extracellular matrix proteins ( ECMPs ) of the basement membrane type , such as the heparan sulfate proteoglycan perlecan , laminin , entactin , collagen 4 , and fibronectin are present in and have been implicated in the genesis of amyloids . ^^^ The binding of entactin to beta PPs was stimulated by collagen 4 but was markedly inhibited by laminin , perlecan , and fibronectin . ^^^ Conversely , the presence of entactin inhibited the binding of perlecan , laminin , and fibronectin to beta PPs . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Histologic preparations of lungs from 1 , 5 , 10 , 18 , and 25 day old postnatal and adult rats were examined immunohistochemically with antibodies specific against chondroitin sulfate ( CS ) , basement membrane chondroitin sulfate proteoglycan ( BM CSPG ) , heparan sulfate proteoglycan ( HSPG ) , entactin , and laminin . ^^^ These results offer a more detailed perspective on previous survey observations of CSPG , HSPG , and entactin in the rat lung , and describe the immunoreactivity of CS for the first time . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| The assembly of BM is believed to involve the independent polymerization of collagen type 4 and laminin , as well as high affinity interactions between laminin , entactin / nidogen , perlecan , and collagen type 4 . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| BM 180 has a mobility of 180 and 60 kDa in the absence or presence of dithiothreitol , respectively , and shows no immunological identity by competitive enzyme linked immunosorbent assay with laminin 1 , collagen 4 , entactin , fibronectin , BM 40 , perlecan , or vitronectin . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Their composition is known to include type 4 collagen , laminin , entactin , heparan sulfate proteoglycan ( HSPG , perlecan ) , and chondroitin sulfate proteoglycan ( CSPG ) . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Around and beneath the epithelial plugs and along the keratotomy scars , deposits of types 3 , 6 , 8 , and 14 collagen ; fibrillin 1 ; fibronectin ; and tenascin C were found , together with short streaks of types 4 ( alpha 1 alpha 2 ) and 7 collagen , laminin 1 and 5 , entactin , and perlecan . alpha 3 alpha 4 Type 4 collagen chains were abnormally absent from the BM around the epithelial plugs . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| The lens capsule , however , shows no qualitative changes in the major basal lamina proteins laminin , collagen 4 , perlecan or entactin . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Immunolocalization of major basement membrane components showed that type 4 collagen , laminin , perlecan and entactin ( nidogen ) were continuously integrated on the lamina densa in T 2 Fgel . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| The onset of the induction of laminin B 2 , entactin and alpha 1 type 4 collagen gene expression prior to the appearance of amyloid deposits , and our previous data with the heparan sulfate proteoglycan , perlecan , suggests these basement membrane proteins may play a role in the initial stages of AA fibrillogenesis . . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| During AA amyloidosis , the major basement membrane components , collagen type 4 ( C 4 ) , entactin , laminin and perlecan codeposit both spatially and temporally with AA fibrils . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Corresponding to lamina densa formation , immunohistochemical analysis of laminin , type 4 collagen , perlecan , and entactin ( nidogen ) indicated integration of these components in a linear array beneath the SV 40 T2 cells . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis of laminin 1 , type 4 collagen , entactin ( nidogen ) and perlecan in the culture indicated that all these components were integrated into a sheet structure of basement membrane beneath the cells . ^^^ Therefore , we concluded that the alveolar epithelial cells synthesize laminin 1 , entactin , type 4 collagen , and perlecan , but that they also needed to assemble exogenous laminin 1 into the basement membrane to complete its formation in vitro . . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| At each time point , confocal immunofluorescence microscopy was used to localize several proteins found in the basement membrane including laminin 5 , entactin , and perlecan . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| In addition , when purified heparan sulfate proteoglycan ( HSPG ) and purified laminin entactin ( LN / ET ) complex were incubated with the venom we observed a partial degradation of the protein core of HSPG as well as the hydrolysis of entactin . ^^^ The above results suggest that the L . intermedia venom has a deleterious effect on the endothelium of vessels both in vivo and in culture , removing important constituents such as HSPG and entactin that are involved in the adhesion of endothelial cells and of subendothelial ECM organization . . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Nidogen 2 interacted with collagens 1 and 4 , and perlecan at a comparable level to nidogen 1 but failed to bind to fibulins . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| More moderate affinities were observed for fibulin 1 , laminin 1 and perlecan , while several other ligands such as collagens , nidogen 1 , fibronectin and BM 40 showed little or no binding . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| It has been proposed that nidogen 1 connects the laminin and collagen 4 networks , so stabilizing the basement membrane , and integrates other proteins , including perlecan , into the basement membrane . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Structural basis for the high affinity interaction of nidogen 1 with immunoglobulin like domain 3 of perlecan . ^^^ We have solved the crystal structure at 2 . 0 A resolution of the mouse nidogen 1 G 2 perlecan IG 3 complex . ^^^ Perlecan IG 3 belongs to the 1 set of the IG superfamily and binds to the wall of the nidogen 1 G 2 beta barrel using beta strands C , D and F . ^^^ Nidogen 1 residues participating in the extensive interface are highly conserved , whereas the corresponding binding site on perlecan is more variable . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Nidogen 1 is a major mediator in the formation of ternary complexes with laminins , collagen 4 , perlecan and fibulins . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| The regeneration occurred within 6 h after the laminin 1 chase by forming a morphologically complete basal lamina that included all known basal lamina proteins from chick embryos , such as laminin 1 , nidogen 1 , collagens 4 and 18 , perlecan , and agrin . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| A wide variety of laminin subunits , together with nidogen 1 and 2 , and perlecan were identified within the basement membrane region of epithelial ducts , lobules , and alveoli in both human and mouse mammary gland . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Mouse nidogen 1 and 2 interacted at comparable levels with collagen 4 , perlecan , and fibulin 2 and , most notably , also with laminin 1 fragments P 1 and gamma1III3 5 , which both contain the gamma1III4 module . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Perlecan and nidogen 1 subsequently become components of the follicular basal lamina , and there is an increase in the amount of laminin chains alpha 1 , beta 2 and gamma 1 , at least in cows . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Focimatrix contains collagen type 4 subunits alpha 1 and alpha 2 ( but not alpha 3 alpha6 ) , and laminin chains alpha 1 , beta 2 and gamma 1 ( but not alpha 2 or beta 1 ) , and nidogen 1 and perlecan ( but not versican ) . ^^^ The expression in granulosa cells of two components examined , nidogen 1 and perlecan , also increases substantially when follicles enlarge to a sufficient size capable of ovulating . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Moreover , maternal epithelial as well as mesenchymal cells expressed laminins , nidogen 1 and nidogen 2 , collagen type 4 , and perlecan . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| It contained collagen type 4 alpha 1 , laminins beta 2 and gamma 1 , nidogen 1 and perlecan and underwent changes in composition similar to that of the follicular basal lamina . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| Perlecan and nidogen 1 and 2 subsequently become components of the follicular basal lamina , and there is an increase in the amount of laminin chains alpha 1 , beta 2 , and gamma 1 , in the bovine at least . ^^^ |
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| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14543 and P98160 |
Pubmed |
SVM Score :0.0 |
| NA |
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