| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.62272881 |
| Activation of phospholipase D 1 by direct interaction with ADP ribosylation factor 1 and RalA . 0.62272881^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Chem . 270 , 29640 29643 ) . hPLD 1 is stimulated by phosphatidylinositol 4 , 5 bisphosphate and the small GTP binding protein known as ADP ribosylation factor 1 . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly , ARF 1 stimulated the activity of hPLD 2 expressed in insect cells about 2 fold , compared with a 20 fold stimulation of hPLD 1 activity . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| In vitro , ARNO diglycine and cytohesin 1 triglycine enhanced phospholipase D 1 ( PLD 1 ) activation by Arf 1 with near maximal effects at 250 nM . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Characterization of recombinant human PLD 1 reveals that it is membrane associated , selective for phosphatidylcholine , stimulated by phosphatidylinositol 4 , 5 bisphosphate , activated by the monomeric G protein ADP ribosylation factor 1 , and inhibited by oleate . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Both of the rat PLD 1 isoforms expressed in the fission yeast Schizosaccharomyces pombe were dependent on ADP ribosylation factor 1 and phosphatidylinositol 4 , 5 bisphosphate . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Although potent activators of mammalian PLD 1 , Arf 1 proteins did not influence the catalytic activities of either Spo 14 or ScPld 2 , a second yeast PLD . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| PLD 1 is activated in a synergistic manner in vitro by protein kinase C alpha , ADP ribosylation factor 1 ( ARF 1 ) , and Rho family members . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| We additionally reported that PLD 1 is activated in a synergistic manner by protein kinase c alpha ( PKC alpha ) , ADP ribosylation factor 1 ( ARF 1 ) , and Rho family members . ^^^ We show that the amino terminal 325 amino acids are required for PKC alpha activation of PLD 1 but not for activation by ARF 1 and RhoA . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| This PLD activity required the presence of Arf 1 , a Rho family member and PKC for efficient catalysis of the lipid substrate , suggesting that the activity represents PLD 1 . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| ARF 1 strongly activated PLD 1 in a dose dependent manner , and PLD 2 was slightly responsive . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Catalytically inactive constructs of PLD 2 and RhoA , but not PLD 1 , ADP ribosylation factor 1 ( ARF 1 ) , ARF 6 , or ADP ribosylation factor nucleotide exchange factor ( ARNO ) blocked Ang 2 induced PLD activity in SHR and WKY PGSMCs . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| These effects have been related to preventing activation by ARF 1 , RhoA , and protein kinase C alpha and beta and therefore indicate that PLD 1 is inhibited . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Basal specific activity of PLD 1 and the concentration of ARF 1 were 3 4 times higher in Golgi enriched membranes from MDCK cells compared with CHO cells . ^^^ Specificity was demonstrated , since dihydro C 2 ceramide had no significant effect on ARF 1 translocation , PLD 1 activation or vesicle formation in membranes from both cell types . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| However , PLD 2 is fully active in the presence of this phospholipid , whereas PLD 1 activation is dependent on additional factors such as ADP ribosylation factor 1 ( ARF 1 ) and protein kinase Calpha . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Constitutive class 1 mGluR internalization is not dependent on the downstream Ral effector proteins Ral binding protein 1 and PLD 1 or either ADP ribosylation factors ARF 1 or ARF 6 . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Arf 1 dependent PLD 1 is localized to oleic acid induced lipid droplets in NIH3T3 cells . ^^^ Furthermore , co existence of PLD 1 , Arf 1 , and ADRP was observed in the LD enriched subcellular fractions obtained from oleic acid treated NIH3T3 cells by Western blot analysis . ^^^ PLD 1 activity in the LD enriched fractions was stimulated by exogenously added Arf 1 . ^^^ Taken together , the data suggest that the activation of Arf 1 dependent PLD 1 occurs in LDs and may be involved in their physiological function . . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| Arf 1 , a catalytic activator , stimulated PLD 1 by enhancing the catalytic constant , kcat . ^^^ |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13393 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|