| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly , ARF 1 stimulated the activity of hPLD 2 expressed in insect cells about 2 fold , compared with a 20 fold stimulation of hPLD 1 activity . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| The native and recombinant proteins have indistinguishable properties : PLD 2 is potently activated by phosphoinositides with a vicinal 4 , 5 phosphate pair but is not stimulated by guanosine 5 ' O ( 3 thio triphosphate ) activated ADP ribosylation factor 1 , Rho family GTP binding proteins , or protein kinases C alpha , or beta 1 . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| These results suggest that PLD 2 is reciprocally regulated in sarcolemmal membranes by alpha actinin and ARF 1 and accordingly that a major role for PLD 2 in cardiac function may involve reorganization of the actin cytoskeleton . . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| ARF 1 strongly activated PLD 1 in a dose dependent manner , and PLD 2 was slightly responsive . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| Catalytically inactive constructs of PLD 2 and RhoA , but not PLD 1 , ADP ribosylation factor 1 ( ARF 1 ) , ARF 6 , or ADP ribosylation factor nucleotide exchange factor ( ARNO ) blocked Ang 2 induced PLD activity in SHR and WKY PGSMCs . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| In a previous paper , we reported that alpha actinin inhibited PLD 2 activity in an interaction dependent and an ADP ribosylation factor 1 ( ARF 1 ) reversible manner ( Park , J . ^^^ Furthermore , ARF 1 could steer the PLD 2 activity in a positive direction regardless of the inhibitory effect of beta actin on PLD 2 . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| However , PLD 2 is fully active in the presence of this phospholipid , whereas PLD 1 activation is dependent on additional factors such as ADP ribosylation factor 1 ( ARF 1 ) and protein kinase Calpha . ^^^ Studies with pertussis toxin and other agents indicate that mastoparan stimulates PLD 2 independently of G ( 1 ) , ARF 1 , protein kinase C , and calcium . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| In contrast , dominant active ARF 1 or Rac 1 stimulated both PLD isozymes but the ARF 1 effect on PLD 2 was very small . ^^^ |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14939 and P84077 |
Pubmed |
SVM Score :0.0 |
| NA |
|