| We examined the mineralocorticoid effect of carbenoxolone ( CBX ) in young PHA patients with either renal or multisystem resistance to aldosterone to find out whether CBX may help reduce the requirement for a high salt diet . ^^^ CBX did not show any significant salt retaining effect in two patients with multiple PHA , and did not affect the renin aldosterone system . ^^^ In contrast , CBX significantly suppressed the renin aldosterone system in a renal PHA patient for the whole duration of treatment , but without a long term salt retaining effect . ^^^ The complete lack of effect of CBX on the renin aldosterone system in multisystem PHA patients indicates that CBX does not exert an effect via mineralocorticoid ( MR ) or glucocorticoid receptors . ^^^ The response to CBX suggests that there is at least a partly functional MR in renal PHA patients . . ^^^ |