| Interacting proteins: Q9NZC4 and P78545 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , overexpression of EBS binding proteins ESE 1 and ESE 3 significantly stimulated SPRR1B promoter activity . ^^^ Furthermore , preceding SPRR1B transcription , PMA up regulated mRNA expression of ETS family members such as ESE 1 and ESE 3 . ^^^ |
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| Interacting proteins: Q9NZC4 and P78545 |
Pubmed |
SVM Score :0.0 |
| These Epithelial specific Ets ( Ese ) factors , cluster into two groups based on the sequence of the Ets DNA binding domain : ( 1 ) Ese 1 , Ese 2 and Ese 3 , and ( 2 ) the more divergent , Pdef . ^^^ |
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| Interacting proteins: Q9NZC4 and P78545 |
Pubmed |
SVM Score :0.0 |
| The putative 300 amino acid Ehf protein is a highly divergent ets family member , but is most related to the recently identified oncoprotein ESX ( 36 % overall and 84 % ETS domain amino acid identity ) . ^^^ Thus , Ehf and ESX comprise a new ets subfamily . ^^^ Because of its presence in somatotroph tumors and its relationship to ESX , Ehf may represent a new oncoprotein . . ^^^ |
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| Interacting proteins: Q9NZC4 and P78545 |
Pubmed |
SVM Score :0.0 |
| Analysis of the ability of constructs encoding nine Ets family members to activate the HER2 / neu promoter revealed three patterns of gene activation : ( 1 ) no effect or repressed promoter activity ( Elk 1 and NET ) ; ( 2 ) intermediate activity ( ER 81 , GABP , ESX , and HA Ets 2 ) ; and , ( 3 ) maximal activity ( Ets 1 , VP 16 Ets 1 , and EHF ) . ^^^ |
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| Interacting proteins: Q9NZC4 and P78545 |
Pubmed |
SVM Score :0.0 |
| ESE 3 , a novel member of an epithelium specific ets transcription factor subfamily , demonstrates different target gene specificity from ESE 1 . ^^^ ESE 3 shows highest homology to two other epithelium restricted Ets factors , ESE 1 and ESE 2 . ^^^ ESE 3 , like ESE 1 and ESE 2 , is exclusively expressed in a subset of epithelial cells with highest expression in glandular epithelium such as prostate , pancreas , salivary gland , and trachea . ^^^ Although ESE 3 and ESE 1 bind with similar affinity to various Ets binding sites , ESE 3 and ESE 1 differ significantly in their ability to transactivate the promoters containing these sites . ^^^ Our results support the notion that ESE 1 , ESE 2 , and ESE 3 represent a unique epithelium specific subfamily of Ets factors that have critical but distinct functions in epithelial cell differentiation and proliferation . . ^^^ |
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| Interacting proteins: Q9NZC4 and P78545 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of the epithelial ETS transcription factors ELF 5 , ESE 3 , and ELF 3 was assessed by RT PCR in the human RPE cell lines D 407 and hTERT RPE 1 . ^^^ |
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