| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Ku 70 , DNA PKcs , DNA Ligase 4 , Xrcc 4 ) were observed . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Cells lacking XRCC 4 are hypersensitive to ionising radiation and defective in 5 ( D ) J recombination [ 3 ] [ 6 ] , implicating DNA ligase 4 in the pathway of nonhomologous end joining ( NHEJ ) of DNA double strand breaks mediated by XRCC 4 , the Ku70 / 80 heterodimer and the catalytic subunit of DNA dependent protein kinase ( DNA PKcs ) in mammalian cells ( reviewed in [ 7 ] ) . ^^^ Thus , unlike Ku70 / 80 and DNA PKcs [ 11 ] [ 12 ] [ 13 ] [ 14 ] , DNA ligase 4 has an essential function in early mammalian development . . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Aside from DNA PK , XRCC 4 and DNA ligase 4 , other proteins which play a role ( s ) in this repair pathway remain unknown ; DNA PK contains a catalytic subunit ( DNA PKcs ) and a DNA binding subunit ( Ku 70 and Ku 80 ) . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Any defect in one of the known components of the DNA repair / V ( D ) J recombination machinery ( Ku 70 , Ku 80 , DNA PKcs , XRCC 4 and DNA ligase 4 ) leads to abortion of the 5 ( D ) J rearrangement process , early block in both T and B cell maturation , and ultimately to severe combined immune deficiency ( SCID ) in several animal models . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Mammalian nonhomologous DNA end joining employs Ku 70 , Ku 80 , DNA dependent protein kinase catalytic subunit ( DNA PKcs ) , XRCC 4 , and DNA ligase 4 ( Lig 4 ) . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , double strand breaks in DNA can be repaired by nonhomologous end joining ( NHEJ ) , a process dependent upon Ku70 / 80 , DNA PKcs , XRCC 4 , and DNA ligase 4 . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Ku 86 together with Ku 70 , DNA PKcs , XRCC 4 and DNA ligase 4 forms a complex involved in repairing DNA double strand breaks ( DSB ) in mammals . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| In addition to Ku , three other polypeptides in the same DNA repair pathway have more recently been identified as autoantigens : the DNA dependent protein kinase catalytic subunit , DNA ligase 4 , and XRCC 4 . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| NHEJ can be catalyzed by mammalian whole cell extract in a reaction dependent upon DNA ligase 4 , Xrcc 4 , Ku 70 , Ku 80 , and DNA PKcs . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Detailed examination indicates that the patient is defective neither in the known factors involved in NHEJ in mammals ( Ku 70 , Ku 80 , DNA dependent protein kinase catalytic subunit , Xrcc 4 , DNA ligase 4 , or Artemis ) nor in the Mre11 / Rad50 / Nbs1 complex , whose homologue in Saccharomyces cerevisiae functions in NHEJ . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Cells of higher eukaryotes process within minutes double strand breaks ( DSBs ) in their genome using a non homologous end joining ( NHEJ ) apparatus that engages DNA PKcs , Ku , DNA ligase 4 , XRCC 4 and other as of yet unidentified factors . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly , however , we found that nonhomologous end joining ( NHEJ ) , another DSB repair pathway , has no positive role in the relevant repair ; notably , DT 40 cell mutants lacking either of the NHEJ factors ( namely , Ku 70 , DNA dependent protein kinase catalytic subunit , and DNA ligase 4 ) were resistant to killing by CPT . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Proteins required for NHEJ include the catalytic subunit of the DNA dependent protein kinase ( DNA PKcs ) , Ku , XRCC 4 and DNA ligase 4 . ^^^ Current models predict that DNA PKcs , Ku , XRCC 4 and DNA ligase 4 assemble at DSBs and that the protein kinase activity of DNA PKcs is essential for NHEJ mediated repair of DSBs in vivo . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| DSB infliction specifically induced a dose and time dependent mobilization of Ku70 / 80 , DNA PKcs , XRCC 4 , and DNA ligase 4 proteins from a soluble nucleoplasmic compartment to a less extractable nuclear fraction . ^^^ We established that under conditions of genomic DSB infliction 1 ) Ku recruitment was not dependent on the co recruitment of the other NHEJ proteins , 2 ) DNA PKcs was physically required for the mobilization of the XRCC 4 ligase 4 complex , 3 ) DNA ligase 4 was physically necessary for stable recruitment of XRCC 4 , and 4 ) phosphorylation of either H2AX or XRCC 4 was unnecessary for DNA PK or XRCC 4 ligase 4 recruitment . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| The main components of the NHEJ system in eukaryotes are the catalytic subunit of DNA protein kinase ( DNA PKcs ) , Ku proteins , XRCC 4 , DNA ligase 4 , and Artemis . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Proteins known to play a role in NHEJ include the DNA dependent protein kinase catalytic subunit ( DNA PKcs ) , the Ku 70 / Ku 80 heterodimer ( Ku ) , XRCC 4 , and DNA ligase 4 . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| Recent genetic and biochemical studies have provided important insights into the mechanism of nonhomologous end joining ( NHEJ ) in higher eukaryotes , and have helped to characterize several components including DNA PKcs , Ku , DNA ligase 4 , and XRCC 4 . ^^^ |
|
| Interacting proteins: P49917 and P78527 |
Pubmed |
SVM Score :0.0 |
| LOH was recurrently observed for 8 of the 9 studied genes ( KU 70 , KU 80 , XRCC 4 , LIG 4 , Artemis , MRE 11 , RAD 50 , NBS 1 ) but not for DNA PKcs . ^^^ |
|