| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Apoptosis was detected after high dose ionizing radiation exposure , and this process was accompanied by specific degradation of DNA PKcs , ATM , and poly ( ADP ribose ) polymerase . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Increased recruitment of cells undergoing apoptosis was associated with enhanced anti CD 95 induced proteolytic cleavage of the most receptor proximal cysteine protease caspase 8 , subsequent cleavage and activation of the machinery protease caspase 3 , and cleavage of the caspase substrates DNA dependent protein kinase catalytic subunit , poly ( ADP ribose ) polymerase and lamin B 1 . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| After 60 min of occlusion , the amount of DNA PKcs and the enzyme poly ( ADP ribose ) polymerase ( PARP ) decreased with the same time course during reperfusion . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| We also demonstrated the redistribution of activated caspase 3 to the nuclear compartment where it locally cleaves DNA PKcs and poly ( ADP ribose ) polymerase , and cleaved fragments were released in the cytosolic compartment . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Introduction of the RARbeta gene into MDA MB 231 cells resulted in a gain of RA sensitivity . 8 Cl cAMP acted synergistically with all trans RA in inducing and activating RARbeta gene expression that correlates with the reduction in mitochondrial membrane potential , redistribution of cytochrome c , activation of caspases , cleavage of poly ( ADP ribose ) polymerase and DNA dependent protein kinase ( catalytic subunit ) , and induction of apoptosis . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Morphology , terminal transferase mediated dUTP digoxigenin nick end labelling ( TUNEL ) and immunohistochemistry for the pro apoptotic enzyme caspase 3 ( CASP 3 ) , for its substrates poly ( ADP ribose ) polymerase ( PARP ) and the DNA dependent protein kinase catalytic subunit ( DNA PKCS ) and for poly ( ADP ribose ) ( PAR ) , an end product of PARP activity , were used to investigate neuronal death in brain infarcts from 15 men and 20 women , aged 46 95 years . ^^^ Neuronal DNA PKCS , PARP and poly ( ADP ribose ) immunoreactivity was demonstrable in scattered neurones in and adjacent to infarcts for 18 24 h but thereafter declined to below detectable levels in most cases . ^^^ Between 3 days and 3 weeks , CASP 3 and DNA PKCS were detected in proliferating capillaries and CASP 3 , PARP and poly ( ADP ribose ) in infiltrating macrophages . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Cleavage and inactivation of DNA PKcs is prevented by prior addition of the anti apoptotic protein Bcl 2 or inhibition of an apoptotic protease that has characteristics of the CPP 32 / Ced 3 family of cysteine proteases that cleave poly ( ADP ribose ) polymerase . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| In addition to DNA PKcs cleavage , specific proteolytic cleavage of the poly ( ADP ribose ) polymerase and generation of nucleosome length DNA ladders was observed in all cell lines following cisplatin treatment . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Decreased Ku DNA binding correlated with reduced protein levels of Ku subunits , DNA PKcs , and poly ( ADP ribose ) polymerase 1 . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| In parallel , protein expression of DNA PKcs and poly ( ADP ribose ) polymerase ( PARP ) as well as DNA PK and caspase 3 activity were investigated . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| The DNA repair proteins poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , Ku 86 , and catalytic subunit of DNA PK ( DNA PKcs ) have been involved in telomere metabolism . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| The accumulation of WRN at double strand breaks was rapid , persisted for many hours , and occurred in the absence of several known interacting proteins including polymerase beta , poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , Ku 80 , DNA dependent protein kinase ( DNA PKcs ) , NBS 1 and histone H2AX . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Cells of mouse knockout cell lines for Ku 80 ( now known as Xrcc 5 ) , Ku 70 ( now known as G22p1 ) , DNA PKcs ( now known as Prkdc ) and PARP ( now known as Adprt ) were synchronized in G 1 phase and exposed to very low fluences of alpha particles . ^^^ G22p1 / cells responded similarly to Xrcc 5 / cells , whereas Prkdc / and Adprt / cells showed an intermediate effect . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| The present studies demonstrate that U 1 70kD and DNA PKcs are excellent substrates for apopain , with cleavage occurring at sites that are highly similar to the cleavage site within PARP . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| The following markers were examined : ( 1 ) heat shock protein 70 ( HSP 70 ) , for reversible injury ; ( 2 ) heme oxygenase 1 , for oxidative stress ; ( 3 & 4 ) two DNA repair proteins , poly ( ADP ) ribose polymerase ( PARP ) and DNA dependent protein kinase catalytic subunit ; ( 5 ) poly ( ADP ) ribose , an end product of PARP activity ; and ( 6 ) caspase 3 active , for apoptosis . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Role of poly ( ADP ribosyl ) ation in DNA PKcs independent 5 ( D ) J recombination . 5 ( D ) J recombination is critical to the generation of a functional immune system . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| The second phase of cleavage ( 50 min ) involved PARP , U 1 70kDa and DNA PKcs , all substrates of the CPP 32 like proteases . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Several of the identified autoantigens are nuclear proteins ( PARP , U 1 70 kDa , and DNA PKcs ) that are substrates for CPP 32 in vitro and in apoptotic cells . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor or staurosporine induced apoptosis of caspase 3 deficient MCF 7 cells resulted in cleavage of the death substrates PARP , Rb , PAK 2 , DNA PKcs , gelsolin , and DFF 45 , but not alpha fodrin . ^^^ Together our results suggest that caspase 3 is essential for cleavage of alpha fodrin , but dispensable for the cleavage of PARP , Rb , PAK 2 , DNA PKcs , gelsolin , and DFF 45 and imply that one or more caspases other than caspases 2 , 3 , and 7 is activated and plays a crucial role in the cleavage of these substrates in MCF 7 cells . . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| To assess the significance of damaged nuclear DNA in autopsy brain tissue in Lewy body disease ( LBD ) , we examined the patterns of expression of two DNA repair enzymes ( PARP and DNA PKCS ) , TUNEL and caspase 3 activation , in sections of midbrain and frontal cortex from nine patients with LBD who had not received L DOPA , and from five neurologically normal controls . ^^^ In LBD but not controls , many neurons and glia in the midbrain had translocated DNA PKCS and PARP from the cytoplasm into the nucleus , particularly in the substantia nigra . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Several mouse models including mice deficient in Ku , DNA PKcs ( Prkdc ) , Parp and Atm , all of which are radiosensitive in vivo , show clear telomere alterations . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| In addition , PARP 1 / cells are shown to be sensitive to the DNA PK inhibitor NU 7026 and DNA PKcs or Ku 80 defective cells shown to be sensitive to PARP inhibitors . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| DNA damage sensors ATM , ATR , DNA PKcs , and PARP 1 are dispensable for human immunodeficiency virus type 1 integration . ^^^ We conclude that the DNA repair enzymes ATM , ATR , DNA PKcs , and PARP 1 are not essential for HIV 1 integration . . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| Down regulation of PARP 1 , but not of Ku 80 or DNA PKcs ' , results in higher gene targeting efficiency . ^^^ |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09874 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|