| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.6075131 |
| Here , we demonstrate that Reelin binds directly to lipoprotein receptors , preferably the very low density lipoprotein receptor ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . 0.6075131^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.52244586 |
| We show that Reelin binds directly and specifically to the ectodomains of VLDLR and ApoER 2 in vitro and that blockade of VLDLR and ApoER 2 correlates with loss of Reelin induced tyrosine phosphorylation of Disabled 1 in cultured primary embryonic neurons . 0.52244586^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.71209595 |
| Biochemical and genetic arguments show that the extracellular matrix protein Reelin binds to two lipoprotein receptors ( VLDLR and ApoER 2 ) , which relay the Reelin signal inside target neurons by docking the tyrosine kinase adapter disabled 1 ( Dab 1 ) . 0.71209595^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Both receptors can bind mDab 1 on their cytoplasmic tails and are expressed in cortical and cerebellar layers adjacent to layers that express Reelin . mDab 1 expression is upregulated in knockout mice that lack both VLDLR and ApoER 2 . ^^^ These findings suggest that VLDLR and ApoER 2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1 . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin binds to transmembrane receptors , including VLDLR and ApoER 2 , and stimulates tyrosine phosphorylation of Disabled 1 ( Dab 1 ) , which associates with an NPxY motif present in the cytoplasmic domain of the receptors . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Mice that are mutant for Reelin or Dab 1 , or doubly mutant for the VLDL receptor ( VLDLR ) and ApoE receptor 2 ( ApoER 2 ) , show disorders of cerebral cortical lamination . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Recently , three membrane proteins , apoER 2 , VLDLR and CNR are identified to bind Reelin . ^^^ The double mutant apoER 2 / ; vldlr / ( ) shows a phenotype indistinguishable from Reelin deficient mice . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin is a secreted extracellular protein that binds to the very low density lipoprotein receptor and the apolipoprotein E receptor 2 on the surface of neurons . ^^^ Disabled 1 ( Dab 1 ) , an intracellular adapter protein containing a PTB ( phosphotyrosine binding ) domain , is tyrosyl phosphorylated during embryogenesis , but it accumulates in a hypophosphorylated form in mice lacking Reelin or both very low density lipoprotein receptor and apolipoprotein E receptor 2 . ^^^ Mice with disruptions in reelin , dab 1 , or both vldlr and apoER 2 are ataxic , and they exhibit severe lamination defects within several brain structures . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in Reelin , Disabled 1 ( Dab 1 ) , or both the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( ApoER 2 ) exhibit identical neuroanatomic defects in laminar structures throughout the brain . ^^^ Reelin is a secreted glycoprotein that binds to VLDLR and ApoER 2 , inducing tyrosine phosphorylation of Dab 1 , an intracellular adapter protein . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| We have studied the organization and cellular differentiation of dentate granule cells and their axons , the mossy fibers , in reeler mutant mice lacking reelin and in mutants lacking the reelin receptors very low density lipoprotein receptor ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ These results indicate that ( 1 ) reelin signaling via ApoER 2 and VLDLR is required for the normal positioning of dentate granule cells and ( 2 ) the reelin signaling pathway is not involved in pathfinding and target recognition of granule cell axons . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| This Reelin dependent augmentation of LTP is abolished in VLDL receptor and apoER 2 knockout mice . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Cellular components of this signaling pathway characterized to date are cell surface receptors for reelin like apolipoprotein E receptor 2 ( ApoER 2 ) , very low density lipoprotein receptor ( VLDLR ) , and cadherin related neuronal receptors , and intracellular components like Disabled 1 and the nonreceptor tyrosine kinase Fyn , which bind to the intracellular domains of the ApoER 2 and VLDL receptor or of cadherin related neuronal receptors , respectively . ^^^ This complex might participate in ApoER 2 specific reelin signaling and thus would explain the different phenotype of mice lacking the ApoER 2 from that of VLDLR deficient mice . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Specialized neurons throughout the developing central nervous system secrete Reelin , which binds to ApoE receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) , triggering a signal cascade that guides neurons to their correct position . ^^^ Binding of Reelin to ApoER 2 and VLDLR induces phosphorylation of Dab 1 , which binds to the intracellular domains of both receptors . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| The DAB 1 protein docks to the intracellular part of the Reelin very low density lipoprotein receptor and apoE receptor type 2 and becomes tyrosine phosphorylated following binding of Reelin to cortical neurons . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Mice lacking Reelin ( Reln ) , double knockouts lacking the VLDL receptor ( VLDLR ) and ApoE receptor 2 ( ApoER 2 ) , and mice lacking disabled 1 ( Dab 1 ) display increased levels of phosphorylated tau . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Transmission of the Reelin signal to migrating embryonic neurons requires binding to the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( apoER 2 ) . ^^^ RESULTS : We show that Reelin activates members of the Src family of non receptor tyrosine kinases ( SFKs ) and that this activation is dependent on the Reelin receptors apoER 2 and VLDLR and the adaptor protein Dab 1 . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Localization of ApoER 2 , VLDLR and Dab 1 in radial glia : groundwork for a new model of reelin action during cortical development . ^^^ Here we provide evidence that the reelin receptor machinery , including the lipoprotein receptors ApoER 2 and VLDLR along with the cytoplasmic adaptor protein Dab 1 , is located in radial glia precursors whose processes span the entire cortical wall from the ventricular zone to the pial surface . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Association analysis of polymorphic CGG repeat in 5 ' UTR of the reelin and VLDLR genes with schizophrenia . ^^^ We examined the polymorphic CGG repeat in the 5 ' untranslated region ( UTR ) of the reelin gene , which was recently found to be associated with autistic disorder , and the CGG repeat in the 5 ' UTR region of the very low density protein receptor ( VLDLR ) gene , which was reported to be associated with sporadic Alzheimer ' s disease , for allelic association with schizophrenia . ^^^ We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin or VLDLR genes , suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2 , thereby inducing tyrosine phosphorylation of the adaptor protein Disabled 1 ( Dab 1 ) and suppressing tau phosphorylation in vivo . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| The Reelin signaling pathway controls neuronal positioning during mammalian brain development by binding to the very low density lipoprotein receptor and apolipoprotein E receptor 2 , and signaling through the intracellular adapter protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin , Disabled 1 ( Dab 1 ) , apolipoprotein E receptor 2 ( ApoER 2 ) , and very low density lipoprotein receptor ( VLDLR ) participate in a signaling pathway required for layer formation during mammalian brain development . ^^^ Binding of purified Reelin to ApoER 2 and VLDLR mediates tyrosine phosphorylation of Disabled 1 . ^^^ Binding of Reelin to ApoER 2 and VLDLR induces a rapid increase in tyrosine phosphorylation of Dab 1 , an adaptor protein that associates with the cytoplasmic domain of the receptors . ^^^ Here we compare the roles of ApoER 2 and VLDLR in Reelin signaling . ^^^ Purified Reelin associated more readily with ApoER 2 than with VLDLR and no synergy was observed in the presence of both receptors . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| We studied the postnatal development of the radial glial scaffold in the dentate gyrus of reeler mice , lacking the extracellular matrix protein Reelin , in scrambler mice , deficient in the intracellular adaptor protein disabled 1 ( Dab 1 ) , which is required for the transmission of the Reelin signal into the cell , and in mutant mice lacking the Reelin receptors apolipoprotein receptor 2 ( ApoER 2 ) and / or the very low density lipoprotein receptor ( VLDLR ) , known to transmit the Reelin signal via Dab 1 . ^^^ By immunolabeling for the glial fibrillary acidic protein ( GFAP ) , we show that a regular dentate radial glial scaffold fails to form in mutants deficient of Reelin , Dab 1 , and VLDLR and ApoER 2 . ^^^ Mutant mice lacking only one of the Reelin receptors , VLDLR or ApoER 2 , display a gradual expression of the radial glial defects seen in mutants that lack both receptors . ^^^ Our results suggest that Reelin signaling via ApoER 2 , VLDLR , and Dab 1 is required for the formation of a regular radial glial scaffold in the dentate gyrus . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Formation of the mammalian six layered neocortex depends on a signaling pathway that involves Reelin , the very low density lipoprotein receptor , the apolipoprotein E receptor 2 ( ApoER 2 ) , and the adaptor protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Very low density lipoprotein receptor and ApoER 2 transmit the extracellular reelin signal into migrating neurons , and thus are key components of the reelin pathway which governs neuronal layering of the forebrain during embryonic brain development . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| In developing mammalian ( mouse ) brain , Reelin ( Reln ) is secreted by the Cajal Retzius ( CR ) neurons in the marginal zone , binds apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( Vldlr ) , and induces the phosphorylation of the downstream cytoplasmic molecule disabled 1 ( Dab 1 ) in cortical plate neurons . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted signaling protein that binds to two members of the low density lipoprotein receptor family , the apolipoprotein E receptor 2 and the very low density lipoprotein receptor , and regulates neuronal positioning during brain development . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| By surface plasmon resonance we demonstrate that apoER 2 exhibits 6 fold higher affinity for Reelin than the very low density lipoprotein receptor ( VLDLR ) , which also functions as a Reelin receptor ( K ( D ) 0 . 2 nM versus K ( D ) 1 . 2 nM ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| The Reelin signal is transduced into the cell by the lipoprotein receptors VLDLR and ApoER 2 , leading to tyrosine phosphorylation of the associated intracellular adaptor protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin is secreted by Cajal Retzius cells and binds to the very low density lipoprotein receptor and apolipoprotein E receptor type 2 receptors on the surface of CP cells , inducing tyrosine phosphorylation of the intracellular Dab 1 adapter . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin promotes hippocampal dendrite development through the VLDLR / ApoER2 Dab 1 pathway . ^^^ Reelin is a secreted glycoprotein that regulates neuronal positioning in cortical brain structures through the VLDLR and ApoER 2 receptors and the adaptor protein Dab 1 . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin binding to apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) leads to phosphorylation of disabled 1 ( Dab 1 ) , an adaptor protein which associates with the intracellular domains of both receptors . ^^^ We show that bivalent agents specifically binding to ApoER 2 or VLDLR are sufficient to mimic the Reelin signal . ^^^ These results suggest that binding of Reelin , which exists as a homodimer in vivo , to ApoER 2 and VLDLR induces clustering of ApoER 2 and VLDLR . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| The Reelin signaling pathway in the brain involves the binding of Reelin to very low density lipoprotein receptors ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| It is possible that variations in reelin related genes ( Reelin , VLDLR , FYN , CNRs , a3b1INTEGRIN , mDAB 1 ) may be involved in the pathogenesis of schizophrenia and Alzheimer ' s disease . ^^^ Previously , we examined the association of the triplet repeats of the reelin and VLDLR gene with schizophrenia . ^^^ We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin nor VLDLR genes ( Akahane et al . 2002 ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Binding of Reelin to the neuronal apolipoprotein E receptors apoER 2 and very low density lipoprotein receptor induces tyrosine phosphorylation of Dab 1 and the subsequent activation or relocalization of downstream targets like phosphatidylinositol 3 ( PI 3 ) kinase and Nckbeta . ^^^ The Reelin induced Dab 1 degradation also depends on apoER 2 and very low density lipoprotein receptor in a gene dose dependent manner . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Moreover , by RT PCR , we show that both reelin receptors ( namely apolipoprotein E receptor [ ApoER 2 ] , very low density lipoprotein receptor [ VLDLR ] and cadherin related neuronal receptor [ CNR ] ) and the cytoplasmic adapter Disabled 1 implicated in the reelin signal transduction , were expressed by trigeminal ganglion . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| The target cells for reelin express the cytoplasmic adapter protein Dab 1 , which binds to the reelin receptors VLDLR and ApoER 2 . ^^^ In mouse , some Cajal Retzius cells express reelin and VLDLR ; in humans , all the components of the signalling pathway ( Reelin , Dab 1 , VLDLR and ApoER 2 ) are present in subsets of Cajal Retzius cells . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| However , examination of mice lacking both reelin receptors , ApoER 2 and VLDLR , did not reveal the same phenotype , suggesting involvement of an additional reelin binding receptor . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| To further investigate these studies , brain levels of Reelin protein and mRNA and mRNAs for VLDLR , Dab 1 , and GSK 3 were investigated . ^^^ CONCLUSIONS : Reductions in Reelin protein and mRNA and Dab 1 mRNA and elevations in Reln receptor VLDLR mRNA demonstrate impairments in the Reelin signaling system in autism , accounting for some of the brain structural and cognitive deficits observed in the disorder . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Within this pathway , Disabled 1 ( Dab 1 ) serves as an intracellular adaptor that is tyrosine phosphorylated when Reelin , a secreted glycoprotein , binds to the lipoprotein receptors VLDLR and ApoER 2 on the surface of neurons . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin , very low density lipoprotein receptor , and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro . ^^^ Reelin binds several receptors , including two members of the low density lipoprotein ( LDL ) receptor family , the apolipoprotein E receptor 2 ( ApoER 2 ) and the very low density lipoprotein receptor ( VLDLR ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| VLDLR is part of the reelin signaling pathway , which guides neuroblast migration in the cerebral cortex and cerebellum . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin , a large protein that regulates neuronal migration during embryonic development , activates a conserved signaling pathway that requires its receptors , very low density lipoprotein receptor and apolipoprotein E receptor 2 , the cytoplasmic adaptor protein Disabled 1 ( Dab 1 ) , and Src family kinases ( SFK ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Among these are the LDL receptor related protein 1 , LRP 1 , a promiscuous and ubiquitously expressed receptor which is critically involved in a multitude of diverse physiological processes ; the Reelin receptors ApoER 2 and VLDL receptor , which participate in neuronal development ; and megalin , a multifunctional receptor expressed in various epithelia . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Mutants lacking the reelin receptors ApoER 2 and Vldlr , and scrambler mice lacking Dab 1 , showed a normal complement of GnRH neurons in the hypothalamus , confirming that the effect of reelin in their migration is independent of Dab1 . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| We have subsequently used these cell lines to study the subcellular localization of ApoER 2 and the VLDL receptor and could demonstrate that receptor mediated Dab 1 phosphorylation does not depend on lipid rafts and that phosphorylated Dab 1 remains bound to the receptor tail when the pathway is activated by Reelin . . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Here we studied whether Reelin from other brain regions can similarly induce this rescue effect and whether it is mediated via the Reelin receptors apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| In the embryonic brain , the binding of Reelin to its receptors ApoER 2 and VLDLR induces subcellular events that include the activation Fyn tyrosine kinase , and plays a crucial role in cortical formation . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reelin signals by binding to two transmembrane receptors , apolipoprotein E receptor 2 ( Apoer 2 ) and very low density lipoprotein receptor . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Loss of the Reln receptor proteins , apolipoprotein receptor 2 and very low density lipoprotein receptor , results in a Reln like phenotype accompanied by increased Dab 1 protein expression . ^^^ This mutant protein is not tyrosine phosphorylated during brain development and is not upregulated to the extent observed in the Reln or the apoER 2 and VLDLR receptor mutants . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| RELN encodes a large ( 388 kD ) secreted protein that acts on migrating cortical neurons by binding to the very low density lipoprotein receptor ( VLDLR ) , the apolipoprotein E receptor 2 ( ApoER 2 ; refs 9 11 ) , alpha3beta1 integrin and protocadherins . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Reln encodes an extracellular protein that regulates layer formation by interacting with VLDLR and ApoER 2 ( Lrp 8 ) receptors , thereby phosphorylating the Dab 1 signaling molecule . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| Increased cell motility was also induced by knockdown of downstream components of the RELN pathway , including ApoER 2 , VLDLR , and DAB 1 . ^^^ |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78509 and P98155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.6075131 |
| Here , we demonstrate that Reelin binds directly to lipoprotein receptors , preferably the very low density lipoprotein receptor ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . 0.6075131^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.52244586 |
| We show that Reelin binds directly and specifically to the ectodomains of VLDLR and ApoER 2 in vitro and that blockade of VLDLR and ApoER 2 correlates with loss of Reelin induced tyrosine phosphorylation of Disabled 1 in cultured primary embryonic neurons . 0.52244586^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.71209595 |
| Biochemical and genetic arguments show that the extracellular matrix protein Reelin binds to two lipoprotein receptors ( VLDLR and ApoER 2 ) , which relay the Reelin signal inside target neurons by docking the tyrosine kinase adapter disabled 1 ( Dab 1 ) . 0.71209595^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Cellular components of this signaling pathway characterized to date are cell surface receptors for reelin like apolipoprotein E receptor 2 ( ApoER 2 ) , very low density lipoprotein receptor ( VLDLR ) , and cadherin related neuronal receptors , and intracellular components like Disabled 1 and the nonreceptor tyrosine kinase Fyn , which bind to the intracellular domains of the ApoER 2 and VLDL receptor or of cadherin related neuronal receptors , respectively . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Loss of the Reln receptor proteins , apolipoprotein receptor 2 and very low density lipoprotein receptor , results in a Reln like phenotype accompanied by increased Dab 1 protein expression . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| RELN encodes a large ( 388 kD ) secreted protein that acts on migrating cortical neurons by binding to the very low density lipoprotein receptor ( VLDLR ) , the apolipoprotein E receptor 2 ( ApoER 2 ; refs 9 11 ) , alpha3beta1 integrin and protocadherins . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin is a secreted extracellular protein that binds to the very low density lipoprotein receptor and the apolipoprotein E receptor 2 on the surface of neurons . ^^^ Disabled 1 ( Dab 1 ) , an intracellular adapter protein containing a PTB ( phosphotyrosine binding ) domain , is tyrosyl phosphorylated during embryogenesis , but it accumulates in a hypophosphorylated form in mice lacking Reelin or both very low density lipoprotein receptor and apolipoprotein E receptor 2 . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in Reelin , Disabled 1 ( Dab 1 ) , or both the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( ApoER 2 ) exhibit identical neuroanatomic defects in laminar structures throughout the brain . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| We have studied the organization and cellular differentiation of dentate granule cells and their axons , the mossy fibers , in reeler mutant mice lacking reelin and in mutants lacking the reelin receptors very low density lipoprotein receptor ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2 , thereby inducing tyrosine phosphorylation of the adaptor protein Disabled 1 ( Dab 1 ) and suppressing tau phosphorylation in vivo . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Specialized neurons throughout the developing central nervous system secrete Reelin , which binds to ApoE receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) , triggering a signal cascade that guides neurons to their correct position . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| The DAB 1 protein docks to the intracellular part of the Reelin very low density lipoprotein receptor and apoE receptor type 2 and becomes tyrosine phosphorylated following binding of Reelin to cortical neurons . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Transmission of the Reelin signal to migrating embryonic neurons requires binding to the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( apoER 2 ) . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin , Disabled 1 ( Dab 1 ) , apolipoprotein E receptor 2 ( ApoER 2 ) , and very low density lipoprotein receptor ( VLDLR ) participate in a signaling pathway required for layer formation during mammalian brain development . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| We studied the postnatal development of the radial glial scaffold in the dentate gyrus of reeler mice , lacking the extracellular matrix protein Reelin , in scrambler mice , deficient in the intracellular adaptor protein disabled 1 ( Dab 1 ) , which is required for the transmission of the Reelin signal into the cell , and in mutant mice lacking the Reelin receptors apolipoprotein receptor 2 ( ApoER 2 ) and / or the very low density lipoprotein receptor ( VLDLR ) , known to transmit the Reelin signal via Dab 1 . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Formation of the mammalian six layered neocortex depends on a signaling pathway that involves Reelin , the very low density lipoprotein receptor , the apolipoprotein E receptor 2 ( ApoER 2 ) , and the adaptor protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Very low density lipoprotein receptor and ApoER 2 transmit the extracellular reelin signal into migrating neurons , and thus are key components of the reelin pathway which governs neuronal layering of the forebrain during embryonic brain development . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| In developing mammalian ( mouse ) brain , Reelin ( Reln ) is secreted by the Cajal Retzius ( CR ) neurons in the marginal zone , binds apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( Vldlr ) , and induces the phosphorylation of the downstream cytoplasmic molecule disabled 1 ( Dab 1 ) in cortical plate neurons . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| The Reelin signaling pathway controls neuronal positioning during mammalian brain development by binding to the very low density lipoprotein receptor and apolipoprotein E receptor 2 , and signaling through the intracellular adapter protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted signaling protein that binds to two members of the low density lipoprotein receptor family , the apolipoprotein E receptor 2 and the very low density lipoprotein receptor , and regulates neuronal positioning during brain development . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| By surface plasmon resonance we demonstrate that apoER 2 exhibits 6 fold higher affinity for Reelin than the very low density lipoprotein receptor ( VLDLR ) , which also functions as a Reelin receptor ( K ( D ) 0 . 2 nM versus K ( D ) 1 . 2 nM ) . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin is secreted by Cajal Retzius cells and binds to the very low density lipoprotein receptor and apolipoprotein E receptor type 2 receptors on the surface of CP cells , inducing tyrosine phosphorylation of the intracellular Dab 1 adapter . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin binding to apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) leads to phosphorylation of disabled 1 ( Dab 1 ) , an adaptor protein which associates with the intracellular domains of both receptors . ^^^ |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Binding of Reelin to the neuronal apolipoprotein E receptors apoER 2 and very low density lipoprotein receptor induces tyrosine phosphorylation of Dab 1 and the subsequent activation or relocalization of downstream targets like phosphatidylinositol 3 ( PI 3 ) kinase and Nckbeta . ^^^ The Reelin induced Dab 1 degradation also depends on apoER 2 and very low density lipoprotein receptor in a gene dose dependent manner . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Moreover , by RT PCR , we show that both reelin receptors ( namely apolipoprotein E receptor [ ApoER 2 ] , very low density lipoprotein receptor [ VLDLR ] and cadherin related neuronal receptor [ CNR ] ) and the cytoplasmic adapter Disabled 1 implicated in the reelin signal transduction , were expressed by trigeminal ganglion . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin , very low density lipoprotein receptor , and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro . ^^^ Reelin binds several receptors , including two members of the low density lipoprotein ( LDL ) receptor family , the apolipoprotein E receptor 2 ( ApoER 2 ) and the very low density lipoprotein receptor ( VLDLR ) . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin , a large protein that regulates neuronal migration during embryonic development , activates a conserved signaling pathway that requires its receptors , very low density lipoprotein receptor and apolipoprotein E receptor 2 , the cytoplasmic adaptor protein Disabled 1 ( Dab 1 ) , and Src family kinases ( SFK ) . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Here we studied whether Reelin from other brain regions can similarly induce this rescue effect and whether it is mediated via the Reelin receptors apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin signals by binding to two transmembrane receptors , apolipoprotein E receptor 2 ( Apoer 2 ) and very low density lipoprotein receptor . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Mice that are mutant for Reelin or Dab 1 , or doubly mutant for the VLDL receptor ( VLDLR ) and ApoE receptor 2 ( ApoER 2 ) , show disorders of cerebral cortical lamination . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| This Reelin dependent augmentation of LTP is abolished in VLDL receptor and apoER 2 knockout mice . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Mice lacking Reelin ( Reln ) , double knockouts lacking the VLDL receptor ( VLDLR ) and ApoE receptor 2 ( ApoER 2 ) , and mice lacking disabled 1 ( Dab 1 ) display increased levels of phosphorylated tau . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Among these are the LDL receptor related protein 1 , LRP 1 , a promiscuous and ubiquitously expressed receptor which is critically involved in a multitude of diverse physiological processes ; the Reelin receptors ApoER 2 and VLDL receptor , which participate in neuronal development ; and megalin , a multifunctional receptor expressed in various epithelia . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| We have subsequently used these cell lines to study the subcellular localization of ApoER 2 and the VLDL receptor and could demonstrate that receptor mediated Dab 1 phosphorylation does not depend on lipid rafts and that phosphorylated Dab 1 remains bound to the receptor tail when the pathway is activated by Reelin . . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Both receptors can bind mDab 1 on their cytoplasmic tails and are expressed in cortical and cerebellar layers adjacent to layers that express Reelin . mDab 1 expression is upregulated in knockout mice that lack both VLDLR and ApoER 2 . ^^^ These findings suggest that VLDLR and ApoER 2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1 . . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin binds to transmembrane receptors , including VLDLR and ApoER 2 , and stimulates tyrosine phosphorylation of Disabled 1 ( Dab 1 ) , which associates with an NPxY motif present in the cytoplasmic domain of the receptors . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Recently , three membrane proteins , apoER 2 , VLDLR and CNR are identified to bind Reelin . ^^^ The double mutant apoER 2 / ; vldlr / ( ) shows a phenotype indistinguishable from Reelin deficient mice . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Association analysis of polymorphic CGG repeat in 5 ' UTR of the reelin and VLDLR genes with schizophrenia . ^^^ We examined the polymorphic CGG repeat in the 5 ' untranslated region ( UTR ) of the reelin gene , which was recently found to be associated with autistic disorder , and the CGG repeat in the 5 ' UTR region of the very low density protein receptor ( VLDLR ) gene , which was reported to be associated with sporadic Alzheimer ' s disease , for allelic association with schizophrenia . ^^^ We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin or VLDLR genes , suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease . . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Localization of ApoER 2 , VLDLR and Dab 1 in radial glia : groundwork for a new model of reelin action during cortical development . ^^^ Here we provide evidence that the reelin receptor machinery , including the lipoprotein receptors ApoER 2 and VLDLR along with the cytoplasmic adaptor protein Dab 1 , is located in radial glia precursors whose processes span the entire cortical wall from the ventricular zone to the pial surface . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| The Reelin signal is transduced into the cell by the lipoprotein receptors VLDLR and ApoER 2 , leading to tyrosine phosphorylation of the associated intracellular adaptor protein Disabled 1 ( Dab 1 ) . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reln encodes an extracellular protein that regulates layer formation by interacting with VLDLR and ApoER 2 ( Lrp 8 ) receptors , thereby phosphorylating the Dab 1 signaling molecule . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Reelin promotes hippocampal dendrite development through the VLDLR / ApoER2 Dab 1 pathway . ^^^ Reelin is a secreted glycoprotein that regulates neuronal positioning in cortical brain structures through the VLDLR and ApoER 2 receptors and the adaptor protein Dab 1 . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| The Reelin signaling pathway in the brain involves the binding of Reelin to very low density lipoprotein receptors ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| It is possible that variations in reelin related genes ( Reelin , VLDLR , FYN , CNRs , a3b1INTEGRIN , mDAB 1 ) may be involved in the pathogenesis of schizophrenia and Alzheimer ' s disease . ^^^ Previously , we examined the association of the triplet repeats of the reelin and VLDLR gene with schizophrenia . ^^^ We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin nor VLDLR genes ( Akahane et al . 2002 ) . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| The target cells for reelin express the cytoplasmic adapter protein Dab 1 , which binds to the reelin receptors VLDLR and ApoER 2 . ^^^ In mouse , some Cajal Retzius cells express reelin and VLDLR ; in humans , all the components of the signalling pathway ( Reelin , Dab 1 , VLDLR and ApoER 2 ) are present in subsets of Cajal Retzius cells . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| However , examination of mice lacking both reelin receptors , ApoER 2 and VLDLR , did not reveal the same phenotype , suggesting involvement of an additional reelin binding receptor . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| To further investigate these studies , brain levels of Reelin protein and mRNA and mRNAs for VLDLR , Dab 1 , and GSK 3 were investigated . ^^^ CONCLUSIONS : Reductions in Reelin protein and mRNA and Dab 1 mRNA and elevations in Reln receptor VLDLR mRNA demonstrate impairments in the Reelin signaling system in autism , accounting for some of the brain structural and cognitive deficits observed in the disorder . . ^^^ The mRNAs for Reln and Dab 1 were reduced significantly whereas the mRNA for Reln receptor VLDLR was elevated significantly in superior frontal and cerebellar areas of autistic brains versus control brains , respectively . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Within this pathway , Disabled 1 ( Dab 1 ) serves as an intracellular adaptor that is tyrosine phosphorylated when Reelin , a secreted glycoprotein , binds to the lipoprotein receptors VLDLR and ApoER 2 on the surface of neurons . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| VLDLR is part of the reelin signaling pathway , which guides neuroblast migration in the cerebral cortex and cerebellum . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Mutants lacking the reelin receptors ApoER 2 and Vldlr , and scrambler mice lacking Dab 1 , showed a normal complement of GnRH neurons in the hypothalamus , confirming that the effect of reelin in their migration is independent of Dab1 . . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| In the embryonic brain , the binding of Reelin to its receptors ApoER 2 and VLDLR induces subcellular events that include the activation Fyn tyrosine kinase , and plays a crucial role in cortical formation . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| Increased cell motility was also induced by knockdown of downstream components of the RELN pathway , including ApoER 2 , VLDLR , and DAB 1 . ^^^ |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P98155 and P78509 |
Pubmed |
SVM Score :0.0 |
| NA |
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