| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.6418719 |
| In the testis , cyclin A 1 has been shown to bind both Cdk 1 and Cdk 2 but we show here that cyclin A 2 binds only Cdk 2 . 0.6418719^^^ |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.68397976 |
| Further , there was a direct interaction between cyclin A 1 and cyclin dependent kinase 1 , as well as a major ATRA receptor , RARalpha , in ATRA treated cells but not in untreated leukemic cells . 0.68397976^^^ |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| In a yeast two hybrid assay , cyclin A 1 can bind to CDK 2 but not to CDC 2 , CDK 4 , and CDK 5 . ^^^ |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| As with cyclin A 1 siRNA in lung cancer cell lines , cyclin B 1 , Cdc 2 and CDK 2 were all significantly downregulated . ^^^ |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| Cyclin A 1 , B 1 , B 2 , and E 1 levels , Cdc 2 and Cdk 2 kinase activity , and Cdc25C phosphorylation states were monitored during early Xenopus embryonic cell cycles . ^^^ |
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| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| Interaction of Xenopus Cdc 2 10 cyclin A 1 with the origin recognition complex . ^^^ This kinase activity also copurifies with ORC over several fractionation steps and was identified as a complex of the Cdc 2 catalytic subunit and cyclin A 1 . ^^^ Reciprocal immunoprecipitations with anti Xenopus Cdc 2 or anti Xenopus cyclin A 1 antibodies specifically co precipitate XOrc 1 and XOrc 2 . ^^^ Our results indicate that Xenopus ORC and Cdc 2 10 cyclin A 1 physically interact and demonstrate a physical link between an active cyclin dependent kinase and proteins involved in the initiation of DNA replication . . ^^^ |
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| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| The meiotic arrest is accompanied by a defect in Cdc 2 kinase activation at the G 2 M transition , raising the possibility that a cyclin A 1 dependent process dictates the activation of MPF . ^^^ Here we show that like Cdc 2 , the expression of B type cyclins is retained in cyclin A 1 deficient spermatocytes , while their associated kinases are kept at inactive states . ^^^ Furthermore , the protein kinase complexes consisting of cyclin A 1 and either Cdc 2 or Cdk 2 phosphorylate both Cdc25A and Cdc25C in vitro . ^^^ |
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| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| Cyclin A 2 expression was strongly correlated with that of its catalytic partners Cdk 1 and Cdk 2 in all types of testicular tumors examined ( p < 0 . 05 ) , whereas a strong correlation between cyclin A 1 and Cdk 1 or Cdk 2 was only seen in non seminomatous GCTs ( p < 0 . 05 ) . ^^^ |
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| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| Genes expressed more abundantly in R+ cells are associated with ( 1 ) tumour growth and metastasis including , betaigH 3 , mts 1 , igfbp 5 protease , and mystique ; ( 2 ) cell division , including cyclin A 1 and cdk 1 ; ( 3 ) signal transduction , including pkcdeltabp and lmw ptp ; and ( 4 ) metabolism including ATPase H+ transporter and ferritin . ^^^ |
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| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| Our present study focused on the expression and prognostic significance of cyclin A 1 and a panel of cell cycle regulatory proteins including cyclin A 2 , cyclin B 1 , cyclin E , CDK 1 , CDK 2 , p 21 and p 27 in bone marrow samples from 40 patients with AML . ^^^ |
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| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| More cdk 1 protein and kinase activities were observed in cyclin A 1 induced cells than in GFP control induced cells . ^^^ Thus , cyclin A 1 might mediate apoptosis and mitotic catastrophe through an unscheduled or inappropriate activation of cdk 1 . ^^^ |
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| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| Meiosis arrest in Ccna 1 / males was associated with increased germ cell apoptosis , desynapsis abnormalities and reduction of Cdc 2 kinase activation at the end of meiotic prophase . ^^^ |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78396 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|