| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.54709209 |
| Although SynGAP binds PSD 95 , both genes had distinct , as well as overlapping expression . 0.54709209^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.62220804 |
| In addition , PSD 95 binds various regulatory proteins including Src , Pyk 2 , SynGAP , and nNOS and may recruit signaling proteins to NMDA receptors . 0.62220804^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| At excitatory synapses , the postsynaptic scaffolding protein postsynaptic density 95 ( PSD 95 ) couples NMDA receptors ( NMDARs ) to the Ras GTPase activating protein SynGAP . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| SynGAP : a synaptic RasGAP that associates with the PSD 95 / SAP90 protein family . ^^^ Here , we describe the isolation of a novel Ras GTPase activating protein , SynGAP , that interacts with the PDZ domains of PSD 95 and SAP 102 in vitro and in vivo . ^^^ SynGAP is selectively expressed in brain and is highly enriched at excitatory synapses , where it is present in a large macromolecular complex with PSD 95 and the NMDA receptor . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| Here , we report a novel synaptic Ras GTPase activating protein ( p 135 SynGAP ) that is a major component of the postsynaptic density , a complex of proteins associated with synaptic NMDA receptors . p 135 SynGAP is almost exclusively localized at synapses in hippocampal neurons where it binds to and closely colocalizes with the scaffold protein PSD 95 and colocalizes with NMDA receptors . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| In contrast to citron , p 135 SynGAP , an abundant synaptic Ras GTPase activating protein that can bind to all three PDZ domains of PSD 95 , and Ca2+ / calmodulin dependent protein kinase 2 ( CaM kinase 2 ) are concentrated postsynaptically at glutamatergic synapses on glutamatergic neurons . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| SynGAP binds to the PDZ domains of PSD 95 / SAP90 and coimmunoprecipitated with PSD 95 . ^^^ The coimmunoprecipitation of SynGAP with PSD 95 decreased after ischemia . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| To further illustrate the mechanisms underlying these processes , we examined the effects of transient ( 15 min ) brain ischemia followed by reperfusion ( 0 , 30 min , 6 h , 1 , 3 days ) on serine phosphorylation of SynGAP and interactions involving SynGAP , postsynaptic density protein 95 ( PSD 95 ) and CaMKII in rat hippocampus . ^^^ PSD 95 promotes CaMKII catalyzed serine phosphorylation of the synaptic RAS GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus . ^^^ The association among SynGAP , PSD 95 and CaMKII had a similar trend as serine phosphorylation of SynGAP . ^^^ Intracrebroventricular infusion of PSD 95 antisense oligodeoxynucleotide not only markedly decreased the protein levels of PSD 95 but also attenuated the elevated serine phosphorylation of SynGAP and the associations among SynGAP , PSD 95 and CaMKII induced by 30 min reperfusion following 15 min brain ischemia . ^^^ The results suggest that the serine phosphorylation of SynGAP catalyzed by CaMKII is immediately increased and that PSD 95 is critical for promoting SynGAP serine phosphorylation after transient brain ischemia . . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| In contrast , introduction of mutant synGAP with a mutated GAP domain or lacking the terminal domain that binds to PSD 95 does not rescue the mutant phenotype , indicating that both domains play a role in control of spine formation . ^^^ Thus , the GAP activity of synGAP and its association with PSD 95 are important for normal regulation of spine and synapse formation in hippocampal neurons . . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the synaptic recruitment of a PSD 95 ligand , synaptic GTPase activating protein ( synGAP ) , was significantly impaired , whereas the clustering of other scaffolding proteins , such as Homer 1c , Shank / Synamon , and PSD 93 / Chapsin 110 was spared . ^^^ In conclusion , the ligand binding affinity of the PDZ domains of PSD 95 , contributed in part via its interaction with the C terminal end of synGAP , plays a critical role in titrating the synaptic clustering of PSD 95 and controlling its tight association with the PSD scaffold , thereby affecting synapse maturation . . ^^^ |
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| Interacting proteins: Q96PV0 and P78352 |
Pubmed |
SVM Score :0.0 |
| Biochemically , SynGAP associates with the PSD in a PSD 95 independent manner , and Psd 95 ( / ) animals develop normal barrels . ^^^ |
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