| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Heteromultimerization and NMDA receptor clustering activity of Chapsyn 110 , a member of the PSD 95 family of proteins . ^^^ Chapsyn 110 , a novel membrane associated putative guanylate kinase ( MAGUK ) that binds directly to N methyl D aspartate ( NMDA ) receptor and Shaker K+ channel subunits , is 70 % 80 % identical to , and shares an identical domain organization with , PSD 95 / SAP90 and SAP 97 . ^^^ In rat brain , chapsyn 110 protein shows a somatodendritic expression pattern that overlaps partly with PSD 95 but that contrasts with the axonal distribution of SAP 97 . ^^^ Indeed , chapsyn 110 and PSD 95 can heteromultimerize with each other and are recruited into the same NMDA receptor and K+ channel clusters . ^^^ Thus , chapsyn 110 and PSD 95 may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors , ion channels , and associated signalling proteins . . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 and its relative chapsyn 110 exist as disulfide linked complexes in rat brain , consistent with head to head multimerization of these proteins in vivo . . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 and chapsyn 110 have been implicated in the clustering of Shaker K+ channels and NMDA receptors in the mammalian brain , and Dlg plays a role in the clustering of Shaker K+ channels at the Drosophila neuromuscular junction ( NMJ ) . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Postsynaptic localization of N methyl D aspartate type glutamate receptors may be mediated by the synapse associated proteins ( SAPs ) SAP 90 , SAP 102 , and chapsyn 110 . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 ( SAP 90 ) , SAP 102 and Chapsyn 110 ( PSD 93 ) are members of the membrane associated guanylate kinase family , and interact with N methyl D aspartate ( NMDA ) receptor NR2A ( GluRepsilon 1 ) and NR2B ( GluRepsilon 2 ) subunits and with Shaker type K+ channel subunits to cluster into a channel complex . ^^^ PSD 95 ( SAP 90 ) , SAP 102 and Chapsyn 110 ( PSD 93 ) are members of the membrane associated guanylate kinase family , and interact with N methyl D aspartate ( NMDA ) receptor NR2A ( GluRepsilon 1 ) and NR2B ( GluRepsilon 2 ) subunits and with Shaker type K+ channel subunits to cluster into a channel complex . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Postsynaptic density ( PSD ) 95 , SAP 102 , and Chapsyn 110 are members of the PSD 95 / SAP90 protein family , which interact with the C terminus of N methyl D aspartate ( NMDA ) receptor and shaker type potassium channel subunits . ^^^ Second , the resulting overall distributions of PSD 95 , SAP 102 , and Chapsyn 110 in the adult mouse brain were consistent with their mRNA distributions . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| The MAGUK family comprises the post synaptic density 95 ( PSD 95 ) protein and closely related molecules such as chapsyn 110 , synapse associated protein 102 ( SAP 102 ) , and SAP 97 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Neuroligin binds to the PDZ domain containing proteins PSD 95 , SAP 102 , Chapsyn 110 , S SCAM , Magi 1 and 3 , Shank 1 and 3 , Pick 1 , GOPC , SPAR , Semcap 3 and PDZ RGS 3 . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Whereas PSD 95 and PSD 93 occur only at postsynaptic sites in hippocampal neurons , SAP 102 also occurs in axons . ^^^ In heterologous cells , PSD 95 and PSD 93 mediate cell surface ion channel clustering , but SAP 102 and SAP 97 do not . ^^^ This selective ion channel clustering activity by MAGUKs is explained by differential palmitoylation , as PSD 93 and PSD 95 are palmitoylated though SAP 97 , and SAP 102 are not . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequences deduced indicate that A . leptorhynchus neurons express homologues of the mammalian PSD 93 , SAP 97 , and SAP 102 MAGUKs and two homologues of mammalian PSD 95 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Two nNOS interacting proteins were identified : the postsynaptic density proteins PSD 93 and PSD 95 . ^^^ PSD 93 , like PSD 95 , binds to nNOS and to the NMDA receptor 2B . ^^^ PSD 93 , however , is unique among PSD 95 / SAP 90 family members in its expression in Purkinje neuron cell bodies and dendrites . ^^^ Given that PSD 93 and PSD 95 each contain multiple potential binding sites for nNOS and the NMDA receptor , complexes involving oligomers of PSD 93 / 95 may help account for the functional as well as the physical coupling of nNOS to NMDA receptors . . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Double labeling experiments were performed for PSD 95 and for SAP 102 or PSD 93 , respectively , two other members of the family of synapse associated proteins . ^^^ In the OPL , however , PSD 95 and PSD 93 were found presynaptically , whereas SAP 102 was located postsynaptically at photoreceptor synapses . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Neuronal nitric oxide synthase ( nNOS ) has a PSD 95 / Dlg / ZO 1 ( PDZ ) domain that can interact with multiple proteins . nNOS has been known to interact with PSD 95 and a related protein , PSD 93 , in brain and with alpha 1 syntrophin in skeletal muscle in mammals . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| The membrane associated guanylate kinases [ Chapsyn 110 / postsynaptic density 93 ( PSD 93 ) , synapse associated protein 90 ( SAP 90 ) / PSD 95 , and SAP 102 ] are believed to cluster and anchor NMDA receptors at the synapse and to play a role in signal transduction . ^^^ At postnatal day 2 ( P 2 ) , SAP 102 was highly expressed , whereas PSD 93 and PSD 95 were low . ^^^ From P 2 through 6 months , PSD 93 and PSD 95 increased . ^^^ From Western blots of hippocampus and immunogold analysis of CA 1 synapses , the high expression of NR2B at P 2 coincides with the high level of SAP 102 at synapses , whereas the later expression of NR2A coincides with that of PSD 93 and PSD 95 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| The majority of NMDA receptor clusters were colocalized with the postsynaptic density proteins PSD 95 , PSD 93 , and SAP 102 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 93 is N terminally palmitoylated ; however , unlike PSD 95 , palmitoylation does not explain the necessity of the N terminus for PSD 93 postsynaptic targeting . ^^^ Furthermore , when the N terminus of PSD 95 is replaced with the first 30 or 64 , but not the first 10 , amino acids of PSD 93 , the chimera is targeted to postsynaptic sites independent of palmitoylation . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| The C terminus of GluR A bound to the PDZ domains of SAP 97 , but not to those of three related MAGUKs , PSD 93 , PSD 95 , and SAP 102 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| The PSD 95 like membrane associated guanylate kinase ( ' MAGUK ' ) family contains three additional members : PSD 93 , synapse associated protein 97 ( SAP 97 ) and SAP 102 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| METHOD : Using in situ hybridization , the authors examined expression of the transcripts encoding NR ( 1 ) isoforms containing exons 5 , 21 , or 22 , and the NMDA receptor related postsynaptic density proteins NF L , PSD 93 , PSD 95 , and SAP 102 . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| By using a sensitive immunogold procedure , we have investigated the organization of two synaptic scaffolding molecules , PSD 95 and PSD 93 , as well as N methyl D aspartate ( NMDA ) and alpha amino 3 hydroxy 5 methylisoxazole 4 proprionic acid ( AMPA ) receptors , at these heterogeneous glutamate signaling sites . ^^^ Immunolabeling for PSD 95 and PSD 93 was present in all major types of putative glutamatergic synapse , suggesting that these proteins are essential components of the synaptic signaling apparatus . ^^^ The linear density and the subsynaptic distribution of PSD 95 / PSD 93 gold particles did not differ significantly between axodendritic and dendrodendritic synapses . ^^^ Our quantitative analysis of olfactory bulb synapses indicates that the density of NMDA receptors is not determined by the complement of PSD 95 / PSD 93 . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| We report here that clinically relevant concentrations of inhalational anesthetics dose dependently and specifically inhibit the PDZ domain mediated protein interaction between PSD 95 or PSD 93 and the N methyl d aspartate receptor or neuronal nitric oxide synthase . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that PSD 95 is unique among PSD 95 family members in that the other members , PSD 93 , SAP 97 , and SAP 102 , do not physically associate with Lyn , Src , or Yes . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Internalization assays reveal that like PSD 95 , both SAP 97 and PSD 93 inhibit NR2B mediated endocytosis . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| These PDZ proteins include the four neuronal membrane associated guanylate kinases , PSD 95 / SAP 90 , PSD 93 / Chapsyn 110 , SAP 97 / hDLG and SAP 102 ; the multi PDZ protein , MUPP 1 ; and the mitochondrial PDZ protein , OMP 25 . ^^^ Although all of these proteins can bind to TARPs in vitro , only two of these , PSD 95 and PSD 93 associate with TARPs in brain . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| In the absence of PSD 93 , PSD 95 still interacted with NR2B and nNOS . ^^^ Deletion of PSD 93 alone does not provide neuroprotection after neonatal HI , possibly a result , in part , of upregulation of PSD 95 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Each family of PSD proteins is selective for a given glutamate receptor subtype , the most well characterized being the NMDA receptor binding proteins PSD 93 , PSD 95 , NF L , and SAP 102 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated dopamine glutamate interactions by measuring the expression of transcripts encoding the subunits for the ionotropic glutamate receptors ( NMDA , AMPA and kainate ) and five NMDAR associated intracellular proteins , PSD 93 , PSD 95 , SAP 102 , NF L and yotiao in the dopaminergic neurons in the substantia nigra pars compacta ( SNc ) of subjects with schizophrenia and a comparison group . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| These included the homologous residues , S 295 on PSD 95 and S 365 on PSD 93 , located between the PDZ 2 and PDZ 3 domains of these proteins ; and S 367 located on the actin binding domain of beta CaMKII . ^^^ The sequence RXXSPV emerged as a common phosphorylation motif of three specialized PSD scaffolding proteins , PSD 95 , PSD 93 , and Shank 3 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Here we describe the cloning of the zebrafish orthologs of PSD 95 , PSD 93 , and two isoforms of SAP 97 . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| We found decreased striatal expression of transcripts encoding PSD 95 and SAP 102 in bipolar disorder and of SAP 102 in major depression and schizophrenia , while no significant changes in NF L and PSD 93 mRNAs were observed . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Using immunoautoradiography the expression levels of NR 1 and NR2B subunits of the NMDA receptor and the postsynaptic density scaffold proteins , PSD 95 , PSD 93 , and neurofilament light ( NFL ) were examined in normal common marmosets ( Callithrix jacchus ) and 1 methyl 4 phenyl 1 , 2 , 3 , 6 tetrahydropyridine ( MPTP ) lesioned animals that exhibited high or low levels of l DOPA induced dyskinesia . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymer chain reaction ( RT PCR ) and immunohistochemistry demonstrated the expression of postsynaptic density proteins PSD 93 and PSD 95 in the stomach and expression levels of PSD 93 and PSD 95 were reduced in W / W ( 5 ) mutants . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| In addition , we studied expression of the NMDA interacting PSD molecules NF L , SAP 102 , PSD 95 and PSD 93 in ACC and DLPFC at both transcriptional and translational levels . ^^^ We found significant changes in the expression of NF L in DLPFC , and PSD 95 and PSD 93 in ACC ; increased transcript expression was associated with decreased protein expression , suggesting abnormal translation and / or accelerated protein degradation of these molecules in schizophrenia . ^^^ |
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| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| The synaptic trafficking of AMPA receptors by the stargazin protein in some neurons , for example , depends on specific interactions between the C terminus of stargazin and the PDZ [ postsynaptic density 95 ( PSD 95 ) / Discs large / zona occludens 1 ] domains of membrane associated guanylate kinase scaffolding proteins PSD 93 or PSD 95 . ^^^ |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15700 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|