| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.5367345 |
| In addition , PSD 95 binds various regulatory proteins including Src , Pyk 2 , SynGAP , and nNOS and may recruit signaling proteins to NMDA receptors . 0.5367345^^^ |
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| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| To further investigate the mechanisms underlying the neuroprotection of PSD 95 deficiency , the interaction of proline rich tyrosine kinase 2 ( Pyk 2 ) with NR2A as well as autophosphorylation ( Tyr 402 ) of Pyk 2 were detected . ^^^ |
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| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the effects of protein tyrosine kinase ( PTK ) and protein tyrosine phosphatase ( PTP ) on the tyrosine phosphorylation of N methyl D aspartate receptor subunit 2A ( NR2A ) and the interactions among NR2A , postsynaptic density protein 95 ( PSD 95 ) , Fyn / Src after brain ischemia / reperfusion ( I / R ) . ^^^ The following results were observed : ( 1 ) the increase in tyrosine phosphorylation of NR2A induced by I / R was suppressed by genistein , an inhibitor of PTK , but was further enhanced by sodium orthovanadate , an inhibitor of PTP , which were administered to the SD rats 20 min before ischemia . ( 2 ) Importantly , genistein and sodium orthovanadate increased and decreased the interactions involving NR2A , PSD 95 , Fyn and Src , respectively . ^^^ These results demonstrated that PTK and PTP were involved in regulating tyrosine phosphorylation of NR2A through changing the interaction among NR2A , PSD 95 , Fyn / Src . . ^^^ |
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| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| Interaction of the tyrosine kinase Pyk 2 with the N methyl D aspartate receptor complex via the Src homology 3 domains of PSD 95 and SAP 102 . ^^^ The proline rich regions in the C terminal half of Pyk 2 bind to the SH 3 domain of PSD 95 and SAP 102 . ^^^ Characterization of PSD 95 and SAP 102 as adaptor proteins for Pyk 2 fills a critical gap in the understanding of the spatial organization of the Pyk 2 Src signaling pathway at the postsynaptic site and reveals a physiological function of the intramolecular SH 3 GK domain interaction in SAP102 . . ^^^ |
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| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the time course and the effect of lithium on Tyr 402 phosphorylation of Pyk 2 and Tyr 416 phosphorylation of Src as well as the association of Pyk 2 and NMDA receptor subunit 2A ( NR2A ) mediated by postsynaptic density protein 95 kDa ( PSD 95 ) in the condition of cerebral ischemia , which was induced by occlusion of the four vessels in Sprague Dawley rats . ^^^ |
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| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| Two different models of brain ischemia were used to examine the evoked changes in the tyrosine phosphorylation of NMDA receptor subunits 2A and 2B ( NR2A and NR2B ) , as well as their interactions with non receptor tyrosine kinases ( NRTKs : FAK , PYK 2 Src ) , and PSD 95 protein . ^^^ Concomitantly , an increased association of NR2B with FAK , PYK 2 , Src and PSD 95 has been observed . ^^^ |
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| Interacting proteins: Q14289 and P78352 |
Pubmed |
SVM Score :0.0 |
| FAK and PYK 2 interact with SAP90 / PSD 95 Associated Protein 3 . ^^^ Using a yeast two hybrid screen and GST pull down assays we show that SAPAP 3 ( SAP90 / PSD 95 Associated Protein 3 ) interacts with FAK ( residues 676 840 ) and PYK 2 . ^^^ |
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