| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.52910192 |
| The postsynaptic protein PSD 95 binds to NMDA receptor subunits NR2A and NR2B and to signaling molecules such as neuronal nitric oxide synthase and p135synGAP . 0.52910192^^^ The association between PSD 95 and NR2A and NR2B , as indicated by coimmunoprecipitation , was less in postischemic samples than in sham operated controls . 0.51274991^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.57496718 |
| In the presence of 1 mM : L glutamate , the K : ( 1 ) for MK 801 binding to NR 1 1a / NR2A with PSD 95 was not significantly different from that for NR 1 1a / NR2A without PSD 95 . 0.57496718^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.64619168 |
| We tested whether synaptic transmission or plasticity was affected by acute dissociation of the PSD 95 NMDA receptor interaction with various peptides that bound to the first two PDZ domains of PSD 95 and its homologs and with antibodies directed against the very C terminus of the NR2A and NR2B subunits of the NMDA receptor . 0.64619168^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.69206341 |
| We also found that the PDZ 2 domain of PSD 95 interacted with the NR2A and NR2B subunits of NMDA receptors . 0.69206341^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.56720419 |
| Furthermore , the association between PSD 95 and NMDAR subunits ( NR 1 , NR2A , and NR2B ) in the hippocampal CA 1 was also markedly altered by perinatal hypoxia . 0.56720419^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Recently , in vitro studies have shown that members of the N methyl aspartate ( NMDA ) class of glutamate receptors interact with a synapse associated protein , SAP 90 ( PSD 95 ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| With the advent of powerful new microchemical tools and molecular genetic methods , three new classes of proteins have been identified in the PSD at glutamatergic synapses : the PSD 95 family , the NR2B subunit of the NMDA type glutamate receptor , and densin 180 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| The distributions of the presynaptic marker synaptophysin , the AMPA type glutamate receptor subunit GluR 1 , and the putative NMDA receptor clustering protein PSD 95 were not affected by blockade . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| To determine their roles in the assembly of glutamatergic postsynaptic sites , we studied the distributions of NMDA and AMPA type glutamate receptors ; the NMDA receptor interacting proteins alpha actinin 2 , PSD 95 , and chapsyn ; and the PSD 95 associated protein GKAP during the development of hippocampal neurons in culture . ^^^ These results suggest that synapse development proceeds by formation of a postsynaptic scaffold containing PSD 95 and GKAP in concert with presynaptic vesicle clustering , followed by regulated attachment of glutamate receptor subtypes to this scaffold . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Postsynaptic localization of N methyl D aspartate type glutamate receptors may be mediated by the synapse associated proteins ( SAPs ) SAP 90 , SAP 102 , and chapsyn 110 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NMDA receptors have been found to bind to the PSD 95 family of proteins , whereas AMPA receptors interact with the PDZ domain containing protein GRIP ( glutamate receptor interacting protein ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Synaptic NMDA type glutamate receptors are anchored to the second of three PDZ ( PSD 95 / Discs large / ZO 1 ) domains in the postsynaptic density ( PSD ) protein PSD 95 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Synaptic vesicle proteins , AMPA and NMDA type glutamate receptors , GABAA receptors , and the putative synapse organizing proteins PSD 95 , GKAP , and gephyrin formed numerous clusters at synaptic sites . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Expression of PSD 95 decreased the sensitivity of the NMDA receptor channels to L glutamate . ^^^ Mutational studies showed that the interaction between the COOH terminus of the epsilon 2 subunit of the NMDA receptor and the second PSD 95 / Dlg / Z0 1 domain of PSD 95 is critical for the decrease in glutamate sensitivity . ^^^ In addition to this , our results suggest that PSD 95 plays a protective role against neuronal excitotoxicity by decreasing the glutamate sensitivity of the channels and by inhibiting the protein kinase C mediated potentiation of the channels . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In cultured hippocampal neurons , MALS proteins are clustered together with PSD 95 and NMDA type glutamate receptors , consistent with a postsynaptic localization for MALS proteins . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In cultured cortical neurons , suppressing the expression of the NMDAR scaffolding protein PSD 95 ( postsynaptic density 95 ) selectively attenuated excitotoxicity triggered via NMDARs , but not by other glutamate or calcium ion ( Ca2+ ) channels . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| By virtue of their multiple protein binding domains ( e . g . , three PDZs in PSD 95 and seven PDZs in GRIP ) , PSD 95 and GRIP can function as multivalent proteins that organize a specific cytoskeletal and signaling complex associated with each class of glutamate receptor . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Postsynaptic density 95 ( PSD 95 / SAP 90 ) is a membrane associated guanylate kinase ( GK ) PDZ protein that scaffolds glutamate receptors and associated signaling networks at excitatory synapses . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| The NMDA subtype of glutamate receptor is physically associated with the postsynaptic density protein PSD 95 at glutamatergic synapses . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| The PDZ domain containing proteins , such as PSD 95 and GRIP , have been suggested to be involved in the targeting of glutamate receptors , a process that plays a critical role in the efficiency of synaptic transmission and plasticity . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that glutamate receptors and PKA are recruited into a macromolecular signaling complex through direct interaction between the MAGUK proteins , PSD 95 and SAP 97 , and AKAP79 / 150 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 , DLG , ZO 1 ( PDZ ) domain mediated protein interactions have been shown to play important roles in the regulation of glutamate receptor function at excitatory synapses . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| We find that glutamate input is necessary for clustering the AMPA type glutamate receptor but not for clustering the NMDA receptor or the associated PSD 95 family scaffold in GABAergic cells ; GABA input is not necessary for clustering the GABA ( A ) receptor or gephyrin in pyramidal cells . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 expression enhanced postsynaptic clustering and activity of glutamate receptors . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In vivo , SAP 90 tightly binds kainate receptor subunits , while SAP 97 is only weakly associated , suggesting that this glutamate receptor differentially associates with SAP90 / PSD 95 family members . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Interdomain chaperoning between PSD 95 , Dlg , and Zo 1 ( PDZ ) domains of glutamate receptor interacting proteins . ^^^ The multiple PSD 95 , Dlg , and Zo 1 ( PDZ ) domain protein , glutamate receptor interacting protein ( GRIP ) , is involved in the clustering and trafficking of the alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate receptor by directly binding to the cytoplasmic tail of the receptor ' s GluR 2 subunit . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| We also studied the synaptic localization of the two postsynaptic density proteins PSD 95 and glutamate receptor interacting protein ( GRIP ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| When coexpressed in human embryonic kidney 293 cells , PrRP receptor was able to coimmunoprecipitate the three PDZ domain proteins known to interact with AMPA receptors : glutamate receptor interacting protein ( GRIP ) , AMPA binding protein ( ABP ) , and protein that interacts with C kinase ( PICK 1 ) , but not the PDZ domain protein PSD 95 , which does not interact with AMPA receptors . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD 95 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Hippocampal mossy fibers induce assembly and clustering of PSD 95 containing postsynaptic densities independent of glutamate receptor activation . ^^^ Antibodies to a prominent postsynaptic density ( PSD ) scaffold protein , PSD 95 , identified large ( > 1 microm ) and irregularly shaped PSD assemblies that codistributed with synapsin 1 or metabotropic glutamate receptor 7b ( mGluR7b ) immunolabeled MF terminals in area CA 3 . ^^^ The results indicate that MF axons can induce the assembly and clustering of PSD 95 containing postsynaptic complexes , displaying a normal subcellular and tissue distribution , by mechanisms that are independent of ionotropic glutamate receptor activation . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Stargazin is the first transmembrane protein known to associate with AMPA ( alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ) glutamate receptors ( AMPARs ) and regulate their synaptic targeting by two distinct mechanisms , specifically via delivery of AMPARs to the surface membrane and synaptic targeting of these receptors by binding to PSD 95 / SAP 90 and related PDZ proteins . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this investigation , we report identification and characterization of a 95 kDa postsynaptic density protein ( PSD 95 ) / discs large / ZO 1 ( PDZ ) domain containing protein termed tamalin , also recently named GRP 1 associated scaffold protein ( GRASP ) , that interacts with group 1 metabotropic glutamate receptors ( mGluRs ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| We quantitatively defined the contributions of carboxyl terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 ( PSD 95 ) and its homolog synapse associated protein 90 ( SAP 102 ) with the NR2b subunit of the N methyl d aspartate type glutamate receptor . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Here , we identify palmitate cycling on PSD 95 at the synapse and find that palmitate turnover on PSD 95 is regulated by glutamate receptor activity . ^^^ We also find that rapid glutamate mediated AMPA receptor internalization requires depalmitoylation of PSD 95 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| DeSouza and Ziff discuss the evidence that the reversible palmitoylation of the postsynaptic density protein PSD 95 may result in the movement of AMPA type glutamate receptors into and out of lipid raft domains , ultimately controlling AMPA receptor accumulation at the postsynaptic membrane . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Delta catenin forms stable complexes with excitatory neurotransmitter receptors including ionotropic N methyl D aspartic acid receptor 2A ( NR2A ) , metabotropic glutamate receptor 1alpha ( mGluR1alpha ) , as well as PSD 95 in vivo . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| The membrane associated guanylate kinase PSD 95 scaffolds N methyl d aspartate receptors to cytoplasmic signaling molecules , and associates with other glutamate receptors at central synapses . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| For glutamate receptor 6 ( GluR 6 ) kainate receptors , two unrelated proteins , concanavalin A ( Con A ) and postsynaptic density protein 95 ( PSD 95 ) , bind to extra and intracellular domains , respectively , but are reported to exert similar effects on GluR 6 desensitization behaviour . ^^^ The rate of desensitization elicited by 10 mM L glutamate was similar in control ( taufast = 5 . 5 + / 0 . 4 ms ) , Con A treated patches ( taufast = 6 . 1 + / 0 . 5 ms ) and patches containing PSD 95 and GluR 6 receptors ( taufast = 4 . 7 + / 0 . 6 ms ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| We have found that DR reduced the expression of the NMDA receptor 2A subunit and its associated protein PSD 95 ( postsynaptic density 95 ) , of GRIP ( AMPA glutamate receptor interacting protein ) , and of the biosynthetic enzyme GAD ( glutamic acid decarboxylase ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| By using a sensitive immunogold procedure , we have investigated the organization of two synaptic scaffolding molecules , PSD 95 and PSD 93 , as well as N methyl D aspartate ( NMDA ) and alpha amino 3 hydroxy 5 methylisoxazole 4 proprionic acid ( AMPA ) receptors , at these heterogeneous glutamate signaling sites . ^^^ Although the lateral dendrites of mitral and tufted cells have been reported to respond to glutamate , they did not display significant plasma membrane labeling for the NR 1 subunit or for PSD 95 , suggesting that the physiological effects of glutamate at these sites are mediated by NMDA autoreceptors that are not clustered and occur only at a low density on the dendritic surface . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| The fragile 10 mental retardation protein is required for type 1 metabotropic glutamate receptor dependent translation of PSD 95 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| This preparation was used to assess the association of alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ( AMPA ) type glutamate receptors with the PSD 95 containing complex . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 is a major scaffolding protein of the postsynaptic density , tethering NMDA and AMPA type glutamate receptors to signaling proteins and the neuronal cytoskeleton . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Each family of PSD proteins is selective for a given glutamate receptor subtype , the most well characterized being the NMDA receptor binding proteins PSD 93 , PSD 95 , NF L , and SAP 102 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In hippocampal slice cultures , the expression of PSD 95 green fluorescent protein ( PSD 95 GFP ) increases AMPAR currents by selectively delivering glutamate receptor 1 ( GluR 1 ) containing receptors to synapses , thus mimicking long term potentiation ( LTP ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated dopamine glutamate interactions by measuring the expression of transcripts encoding the subunits for the ionotropic glutamate receptors ( NMDA , AMPA and kainate ) and five NMDAR associated intracellular proteins , PSD 93 , PSD 95 , SAP 102 , NF L and yotiao in the dopaminergic neurons in the substantia nigra pars compacta ( SNc ) of subjects with schizophrenia and a comparison group . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| We review the potential roles in brain plasticity of two membrane associated guanylate kinases ( MAGUKs ) , SAP 102 and PSD 95 , which form a scaffold for the ion passing glutamate receptors at the postsynaptic density , and we consider the known functional significance of these molecules in subunit switching . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In the postsynaptic density of neuronal excitatory synapses , PDZ proteins such as PSD 95 organize glutamate receptors and their associated signalling proteins and determine the size and strength of synapses . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Clusters of PSD 95 and subunits of AMPA type and NMDA type glutamate receptors accumulate in spines of mutant neurons by day 10 in vitro , whereas in wild type neurons they are still mostly located in dendritic shafts . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| RESULTS : At three days of ethanol withdrawal , we found region specific and sex selective alterations in levels of GAD ( glutamic acid decarboxylase , GABA synthetic enzyme ) , GABA and glutamate transporters , and the synapse associated proteins HSP 70 , PSD 95 , and synaptophysin . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the properties of basal neurotransmission are normal in the Mecp 2 null mice , consistent with our observations that the levels of expression of synaptic and cytoskeletal proteins , including glutamate receptor subunits GluR 1 and GluR 2 , PSD 95 , synaptophysin 1 , synaptobrevin 2 , synaptotagmin 1 , MAP 2 , betaIII tubulin and NF 200 , are not significantly altered . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| A reduction in PSD 95 at glutamate synapses of the molecular layer may have a deleterious impact on information flow to other hippocampal regions via granule cells and their projecting mossy fibres . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In short term neocortical cultures , concentrations of epidermal growth factor and amphiregulin ( 2 9 pM ) decreased the expression of glutamate receptor interacting protein 1 ( GRIP 1 ) and synapse associated protein 97 kDa ( SAP 97 ) without affecting postsynaptic density 95 ( PSD 95 ) levels and glial proliferation . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Among the earliest changes in synaptic composition in APP mutant neurons were reductions in PSD 95 , a protein involved in recruiting and anchoring glutamate receptor subunits to the post synaptic density . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Kainate receptor glutamate receptor 6 ( GluR 6 ) binds to the postsynaptic density protein 95 ( PSD 95 ) , which in turn anchors mixed lineage kinase 3 ( MLK 3 ) via SH 3 domain in rat brain tissue . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| After reviewing its role as a signaling receptor , we discuss the connection between LRP and the NMDA glutamate receptor via the post synaptic density 95 ( PSD 95 ) neuronal scaffold protein and the implications it may have for memory and cognition . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Immunostaining analysis of cortical cultured neurons revealed that Abeta treatment induces concomitant decreases in PSD 95 at synapses and in the surface expression of the AMPAR glutamate receptor subunit 2 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Synapse associated protein 97 ( SAP 97 ) and postsynaptic density 95 ( PSD 95 ) are closely related membrane associated guanylate kinase homologs ( Maguks ) implicated in the synaptic targeting and anchoring of alpha amino 5 methyl 3 hydroxy 4 isoxazolepropionic acid ( AMPA ) selective glutamate receptors . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Postsynaptic density 95 ( PSD 95 ) , a PSD 95 / Discs large / zona occludens 1 ( PDZ ) domain containing scaffold protein , clusters many signaling molecules near NMDA type glutamate receptors in the postsynaptic densities . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| These sexual morphological differences correlate with differences in the postsynaptic dense protein ( PSD 95 ) as well as the spectrum of glutamate receptors induced by GC treatment in male and female mice , including NMDA , AMPA , and KA receptors . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| These data confirm the abundance of calcium / calmodulin dependent protein kinase 2 and PSD 95 and reveal unexpected stoichiometric ratios between glutamate receptors , scaffold proteins , and signaling molecules in the PSD . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| However , activity dependent phosphorylation of substrates at synapses was highly selective in that the glutamate receptor subunits NR2B and GluR 1 were poorly phosphorylated whereas PSD 95 and Stargazin , proteins implicated in the scaffolding and trafficking of AMPA receptors , were robustly phosphorylated . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Applying semi quantitative immunoblotting , we found that in the whole tetanized hippocampus , synaptic expression of the N methyl D aspartate and alpha amino 3 hydroxyl 5 methyl 4 isoxazole propionate receptor subunits ( NR 1 , NR2A , glutamate receptor 1 ) and their associated partners , e . g . synaptic associated protein 97 , postsynaptic density protein 95 , alpha subunit of Ca2+ / calmodulin dependent protein kinase 2 , neuronal nitricoxide synthase , increased 180 min post high frequency stimulation . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| With use of the yeast two hybrid system to screen a rat brain cDNA library and by in vitro binding assays , we have identified an interaction between NMDA receptor subunits 2A and 2B ( NR2A and NR2B ) and three distinct members of the PSD 95 / SAP90 family of membrane associated putative guanylate kinases . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 promotes Fyn mediated tyrosine phosphorylation of the N methyl D aspartate receptor subunit NR2A . ^^^ Results also showed that PSD 95 , which directly binds to and coclusters with NMDA receptors , promotes Fyn mediated tyrosine phosphorylation of NR2A . ^^^ Different regions of PSD 95 associated with NR2A and Fyn , respectively , and so PSD 95 could mediate complex formation of Fyn with NR2A . ^^^ These results suggest that PSD 95 is critical for regulation of NMDA receptor activity by Fyn and other Src family PTKs , serving as a molecular scaffold for anchoring these PTKs to NR2A . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| However , exposure of low glutamine cultures to 100 mM ethanol for 4 days ( starting at culture day 9 ) significantly increased the levels of NMDA receptor subunits ( NR 1 , NR2A , and NR2B ) and AMPA receptor subunits ( GluR 1 and GluR2 / 3 ) , but had no effect upon kainate receptor subunits ( GluR6 / 7 ) or the synapse associated proteins synapsin 1 and PSD 95 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 ( SAP 90 ) , SAP 102 and Chapsyn 110 ( PSD 93 ) are members of the membrane associated guanylate kinase family , and interact with N methyl D aspartate ( NMDA ) receptor NR2A ( GluRepsilon 1 ) and NR2B ( GluRepsilon 2 ) subunits and with Shaker type K+ channel subunits to cluster into a channel complex . ^^^ PSD 95 ( SAP 90 ) , SAP 102 and Chapsyn 110 ( PSD 93 ) are members of the membrane associated guanylate kinase family , and interact with N methyl D aspartate ( NMDA ) receptor NR2A ( GluRepsilon 1 ) and NR2B ( GluRepsilon 2 ) subunits and with Shaker type K+ channel subunits to cluster into a channel complex . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Differential interaction of the tSXV motifs of the NR 1 and NR2A NMDA receptor subunits with PSD 95 and SAP 97 . ^^^ Using the two hybrid genetic system in yeast and site directed mutagenesis , we compared the binding of the NR2A , NR 1 3 and NR 1 4 tSXV motifs with the PDZ domains of PSD 95 and SAP 97 . ^^^ Using immunohistochemistry , we also compared the distribution of the PSD 95 , NR2A and SAP 97 proteins in adult rat brain , and we show that in the cortex , hippocampus and cerebellum , there is evidence for colocalization of these proteins . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Accordingly , NR 1 and NR2A as well as GluR 1 , GluR2 / 3 , PSD 95 and alphaCaMKII protein concentrations in post synaptic densities were the same in both control and diabetic rats , whereas the immunoreactivity for NR2B was reduced by about 40 % . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| To relate this distribution to that of NR 1 and to the NMDA receptor anchoring protein PSD 95 , we documented extensive cellular colocalization of NR2A / B with NR 1 at the light microscopic level . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| N methyl D aspartate ( NMDA ) subunits NR2A and NR2B , bind to the PSD protein called PSD 95 , which in turn binds neuroligins , providing a handle for interacting with neurexin , located in the plasma membrane at the presynaptic active zone . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| From Western blots of hippocampus and immunogold analysis of CA 1 synapses , the high expression of NR2B at P 2 coincides with the high level of SAP 102 at synapses , whereas the later expression of NR2A coincides with that of PSD 93 and PSD 95 . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| On the other hand , cultured cortical neurons are spared by PSD 95 antisense toxicity until they reach a NR2A detectable protein level ( 24 days in vitro ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Recent studies have indicated that tyrosine phosphorylation of NMDA receptor subunit 2A ( NR2A ) by Src family kinases ( Src , Fyn , etc . ) up regulates NMDA receptors activity and postsynaptic density protein 95 kDa ( PSD 95 ) may mediate the regulation . ^^^ Activation of NMDA receptors and L type voltage gated calcium channels mediates enhanced formation of Fyn PSD 95 NR2A complex after transient brain ischemia . ^^^ To investigate whether the above processes are involved in brain ischemia induced enhancement of NMDA receptors function , we examined the effects of transient ( 15 min ) brain ischemia followed by reperfusion on interactions involving Fyn , NR2A and PSD 95 in rat hippocampus by co immunoprecipitation . ^^^ The 15 min reperfusion after brain ischemia induced enhanced co immunoprecipitation of PSD 95 , Fyn and NR2A with one another . ^^^ The associations of PSD 95 with Fyn and NR2A increased at 0 24 h , 0 1 h of reperfusion , up to 6 . 9 and 2 . 1 fold relative to sham groups , respectively . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses of cell homogenates indicated upregulation of NMDA receptor subunits ( NR 1 , NR2A , and NR2B ) , but downregulation of synaptic organizing proteins ( PSD 95 , densin 180 , and septin 6 homologue ) and a synapse enriched enzyme ( alphaCaMKII ) . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Dendritic levels of NR2A increased at the same time in WT and immunoprecipitated with PSD 95 . ^^^ Disrupting photoreceptor activation of retinal ganglion cells eliminated increases in PSD 95 and NR2A in superior collicular dendrites of WT mice and slowed the loss of miniature NMDAR currents in NR2AKOs . ^^^ We hypothesize that NR2A rich NMDARs may be localized to the center of developing synapses by an activity dependent process that involves the targeting of PSD 95 to the postsynaptic density . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| These data suggest that PSD 95 overexpression in CGCs favours synaptic maturation by allowing synaptic insertion of NR2A and depressing expression of NR2B subunits . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| To further investigate a mechanistic dissociation of receptive field properties in the developing visual system , mice carrying a targeted disruption of the NR2A associated 95 kDa postsynaptic density ( PSD 95 ) scaffolding protein were analyzed . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the effects of protein tyrosine kinase ( PTK ) and protein tyrosine phosphatase ( PTP ) on the tyrosine phosphorylation of N methyl D aspartate receptor subunit 2A ( NR2A ) and the interactions among NR2A , postsynaptic density protein 95 ( PSD 95 ) , Fyn / Src after brain ischemia / reperfusion ( I / R ) . ^^^ The following results were observed : ( 1 ) the increase in tyrosine phosphorylation of NR2A induced by I / R was suppressed by genistein , an inhibitor of PTK , but was further enhanced by sodium orthovanadate , an inhibitor of PTP , which were administered to the SD rats 20 min before ischemia . ( 2 ) Importantly , genistein and sodium orthovanadate increased and decreased the interactions involving NR2A , PSD 95 , Fyn and Src , respectively . ^^^ These results demonstrated that PTK and PTP were involved in regulating tyrosine phosphorylation of NR2A through changing the interaction among NR2A , PSD 95 , Fyn / Src . . ^^^ |
|
| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) analysis of RNA extracted from CD34+ derived megakaryocytes identified expression of NR2A and NR2D receptor subunits in these cells , as well as the NMDA receptor accessory proteins , Yotiao and postsynaptic density protein 95 ( PSD 95 ) . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N methyl D aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus . ^^^ The effects of suppression of postsynaptic density protein 95 ( PSD 95 ) expression on the increased tyrosine phosphorylation of N methyl D aspartate receptor subunit NR2A and interactions of Src and Fyn with NR2A after brain ischemia were investigated by immunoprecipitation and immunoblotting . ^^^ Intracerebroventricular infusion of PSD 95 antisense oligonucleotides ( every 24 h for 3 days before ischemia ) , but not missense oligonucleotides or vehicle , not only markedly decreased the protein level of PSD 95 but also attenuated the elevated tyrosine phosphorylation of NR2A and interactions of Src and Fyn with NR2A induced by 6 h of reperfusion following ischemia in the hippocampus . ^^^ These data suggested that PSD 95 is critical for facilitating NR2A tyrosine phosphorylation by Src family kinases in postischemic brain . . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Since brain ischemia results in NMDA receptor over excitation and Src family protein tyrosine kinase mediated tyrosine phosphorylation of NMDA receptor subunit 2A ( NR2A ) enhances NMDA receptor activity , we examined the effects of lithium on tyrosine phosphorylation of NR2A and its interactions with Src and Fyn ( two members of the Src family of protein tyrosine kinases ) mediated by PSD 95 ( postsynaptic density protein 95 kDa ) after 6 h of reperfusion following 15 min of ischemia ( I / R ) , which was induced by occlusion of the four vessels in Sprague Dawley rats . ^^^ After abdominal injection of LiCl ( 2 mg / kg ) for 7 days , the data showed that together with the significant decrease in I / R induced tyrosine phosphorylation of NR2A , the interactions of NR2A with Src and Fyn mediated by PSD 95 were also decreased significantly . ^^^ However , lithium pretreatment did not alter the total protein levels of NR2A , Src , Fyn and PSD 95 . ^^^ These results suggest that the inhibition of NR2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD 95 may contribute to the lithium induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity . . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In order to investigate the possible mechanism of the neuroprotective action of SY 21 , we examined the effects of SY 21 on the ischemia / reperfusion induced increases in tyrosine phosphorylation of the NMDA receptor subunit 2A ( NR2A ) and on the interactions involving NR2A , PSD 95 and Src / Fyn . ^^^ Also , SY 21 attenuated the increased interactions involving NR2A , PSD 95 , Fyn and Src . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Under physiological conditions , PSD 95 , nNOS , NR2A , and NR2B were unaltered in the ( / ) pups . ^^^ However , at 24 hours after HI , protein expression of PSD 95 , nNOS , and NR2A but not NR2B was markedly higher in the ( / ) than in the ( + / + ) pups . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| However , immunoprecipitation studies using PSD 95 suggest that both C2 ' terminal variants and NR2A subunits at the cortical postsynaptic membrane of postnatal day 21 were significantly reduced after prenatal ethanol treatment . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the time course and the effect of lithium on Tyr 402 phosphorylation of Pyk 2 and Tyr 416 phosphorylation of Src as well as the association of Pyk 2 and NMDA receptor subunit 2A ( NR2A ) mediated by postsynaptic density protein 95 kDa ( PSD 95 ) in the condition of cerebral ischemia , which was induced by occlusion of the four vessels in Sprague Dawley rats . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| The cellular expression of NR2A and NR2B and the NR 2 synaptic binding protein postsynaptic density 95 ( PSD 95 ) was examined in the mouse somatosensory cortex and thalamus from postnatal day 2 ( P 2 ) to P 15 using reverse transcription PCR , in situ hybridization histochemistry , and immunocytochemistry . ^^^ The localization of NR2A and NR2B subunits and PSD 95 was then studied at synapses in layer 4 of somatosensory cortex and in the ventral posterior nucleus of the thalamus using high resolution immunoelectron microscopy . ^^^ Synaptic PSD 95 developed independently , although both NR2A and NR2B colocalized with PSD 95 . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| We examined the ability of postsynaptic density 95 ( PSD 95 ) protein to alter the calpain mediated cleavage of NR2A and NR2B . ^^^ Coexpression of PSD 95 with NMDA receptors in human embryonic kidney 293 cells blocked cleavage of NR2A and NR2B by NMDA receptor activated calpain . ^^^ Instead , this effect was eliminated by deletion of the C terminal ESDV motif of NR2A or by overexpression of a palmitoylation deficient PSD 95 mutant lacking the ability to cluster and to interact with NMDA receptors in situ , suggesting a role for association between the C terminus of NR2A and clustered PSD 95 . ^^^ Pharmacological inhibition of palmitoylation disrupted the interaction of PSD 95 with NMDA receptors in cortical neurons and allowed NR2A to be cleaved by calpain , whereas NR2A could not be cleaved in untreated neurons . ^^^ These results indicate that PSD 95 clustering and direct association of NR2A and PSD 95 mediate the blocking effect of PSD 95 on calpain cleavage . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Myosin RLC co localized with NR 1 in the dendritic spines of isolated hippocampal neurons , and was co immunoprecipitated from brain extracts in a complex with NR 1 , NR2A , NR2B , PSD 95 , Adaptor protein 2 and myosin 2 heavy chain . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Two different models of brain ischemia were used to examine the evoked changes in the tyrosine phosphorylation of NMDA receptor subunits 2A and 2B ( NR2A and NR2B ) , as well as their interactions with non receptor tyrosine kinases ( NRTKs : FAK , PYK 2 Src ) , and PSD 95 protein . ^^^ In contrast , ischemia of longer duration ( up to 30 min ) caused an immediate decrease in the protein levels as well as tyrosine phosphorylation of both NR2A and NR2B subunits which was accompanied by the marked attenuation of the association with their investigated molecular partners PSD 95 and NRTKs . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Development was marked by substantial decreases in NR2B and SAP 102 and increases in NR2A , PSD 95 , AMPA receptors , and CaMKII . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Our previous investigation has shown that postsynaptic density protein 95 ( PSD 95 ) is critical for the Src family kinases mediated tyrosine phosphorylation of N methyl d aspartate receptor subunit 2A ( NR2A ) in the postischemic hippocampus . ^^^ To further investigate the mechanisms underlying the neuroprotection of PSD 95 deficiency , the interaction of proline rich tyrosine kinase 2 ( Pyk 2 ) with NR2A as well as autophosphorylation ( Tyr 402 ) of Pyk 2 were detected . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| Hippocampal mRNA expression of the NMDA subunits NR 1 , NR2A and NR2B , insulin like growth factor type 1 receptor ( IGF 1R ) , and postsynaptic density protein 95 ( PSD 95 ) was then measured in the animals by Northern blot analysis . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In the present study , we performed western blot analysis to determine whether protein levels of NMDA receptor subunits ( NR 1 , NR2A , NR2B ) and associated PSD proteins ( NF L , PSD 95 , SAP 102 ) are altered in schizophrenia . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| In cerebral heterotopia , the NR2A and NR2B downregulation was accompanied by less evident reduction of the SAP 97 and PSD 95 proteins of the MAGUK family , thus suggesting that NMDA impairment was associated with altered molecular structure of the postsynaptic membrane . ^^^ |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12879 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
|