| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| The activity of NMDA ( N methyl D aspartate ) receptors is mechanosensitive and dependent on the integrity of actin , suggesting a functionally important interaction between NMDA receptors and the postsynaptic cytoskeleton . alpha Actinin 2 , a member of the spectrin / dystrophin family of actin binding proteins , is identified here as a brain postsynaptic density protein that colocalizes in dendritic spines with NMDA receptors and the putative NMDA receptor clustering molecule PSD 95 . alpha Actinin 2 binds by its central rod domain to the cytoplasmic tail of both NR 1 and NR2B subunits of the NMDA receptor , and can be immunoprecipitated with NMDA receptors and PSD 95 from rat brain . ^^^ |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| To determine their roles in the assembly of glutamatergic postsynaptic sites , we studied the distributions of NMDA and AMPA type glutamate receptors ; the NMDA receptor interacting proteins alpha actinin 2 , PSD 95 , and chapsyn ; and the PSD 95 associated protein GKAP during the development of hippocampal neurons in culture . ^^^ |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| The nonsynaptic NMDA receptors appeared to remain clustered and to coalesce in cell bodies . alpha Actinin 2 , which binds both actin and NMDA receptors , dissociated from the receptor clusters , but PSD 95 remained associated with both the synaptic and nonsynaptic receptor clusters , consistent with a proposed cross linking function . ^^^ |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| PSD 95 is known to cluster Shaker channels and NMDA receptors and the latter is known to couple through alpha actinin 2 to the post synaptic cytoskeleton [ Wyszynski et al . ( 1997 ) Nature 385 , 439 442 ] , but the mechanisms by which Kv channels are linked to the actin cytoskeleton and clustered at specific sites in the heart are unknown . ^^^ |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| In addition , PSD 95 and alpha actinin 2 , proteins essential for anchoring NMDA receptors , were decreased . ^^^ |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| In live imaging experiments , Venus tagged alpha actinin 2 in dendritic spines showed faster turnover than PSD 95 , as determined by fluorescent recovery after photobleaching ( FRAP ) , and individual spines often showed marked fluctuations in alpha actinin content over a time scale of minutes . ^^^ |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35609 and P78352 |
Pubmed |
SVM Score :0.0 |
| NA |
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