| Interacting proteins: P25054 and P78352 |
Pubmed |
SVM Score :0.0 |
| DAP 1 was found to associate with hDLG , PSD 95 , NMDA R and adenomatous polyposis coli protein ( APC ) . ^^^ |
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| Interacting proteins: P25054 and P78352 |
Pubmed |
SVM Score :0.0 |
| Moreover , PSD 95 can form a ternary complex with Frizzled 2 and the adenomatous polyposis coli protein , a negative regulator of Wnt signaling , suggesting that members of the PSD 95 family may serve to recruit intracellular signaling molecules of the Wnt / Frizzled pathway into the vicinity of the receptor . . ^^^ |
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| Interacting proteins: P25054 and P78352 |
Pubmed |
SVM Score :0.0 |
| The colorectal tumour suppressor APC is present in the NMDA receptor PSD 95 complex in the brain . ^^^ RESULTS : We report that PSD 95 interacts with the adenomatous polyposis coli ( APC ) tumour suppressor protein via its PDZ domain . ^^^ Furthermore , we found that PSD 95 , NMDA R and APC are contained in the same complex in vivo . ^^^ PSD 95 NMDA R APC association was found to require two cysteine residues conserved in the amino terminus of PSD 95 that are known to be critical for its multimerization . ^^^ CONCLUSION : Our findings suggest that the PSD 95 NMDA R APC complex forms due to the multimerization of PSD 95 monomers , each of which can associate with either NMDA R or APC . ^^^ |
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| Interacting proteins: P25054 and P78352 |
Pubmed |
SVM Score :0.0 |
| Recently , we found that APC is required for the activity of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid ( AMPA ) receptors by facilitating the clustering of PSD 95 and these receptors at the postsynapse . ^^^ |
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| Interacting proteins: P25054 and P78352 |
Pubmed |
SVM Score :0.0 |
| Microtubule bundling activity of APC is stimulated by interaction with PSD 95 . ^^^ Here , we analyzed the effects of PSD 95 on the microtubule bundling activity of APC . ^^^ The coexpression of APC and PSD 95 in COS 7 cells enhanced microtubule bundle formation compared with the expression of APC alone . ^^^ A mutant APC variant that does not associate with PSD 95 did not enhance microtubule bundling , despite coexpression with PSD 95 . ^^^ Immunoelectron microscopy showed that the APC PSD 95 complex sometimes colocalized on microtubules in processes of cultured neurons . ^^^ |
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