| Interacting proteins: P78337 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the NeuroD 1 heterodimers activate transcription in synergy with Ptx 1 , a Bicoid related homeodomain protein , which also contributes to corticotroph specificity of POMC transcription . ^^^ |
|
| Interacting proteins: P78337 and Q13562 |
Pubmed |
SVM Score :0.0 |
| In corticotrope cells that express POMC , cell specific transcription is conferred in part by the synergistic action of Ptx 1 with the basic helix loop helix factor NeuroD 1 . ^^^ |
|
| Interacting proteins: P78337 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Indeed , pituitary specific transcription of POMC depends on the action of the homeodomain containing transcription factor Pitx 1 and of bHLH heterodimers containing NeuroD 1 . ^^^ We now show lineage restricted expression of NeuroD 1 in pituitary corticotroph cells and a direct physical interaction between bHLH heterodimers and Pitx 1 that results in transcriptional synergism . ^^^ |
|
| Interacting proteins: P78337 and Q13562 |
Pubmed |
SVM Score :0.0 |
| In POMC expressing cells , Pitx 1 , NeuroD 1 and Tpit were shown to be important for cell specific transcription of the POMC gene . ^^^ |
|
| Interacting proteins: P78337 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
|