| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.55013672 |
| Transcriptional synergism between Ptx 1 and SF 1 on two SF 1 target genes , pituitary luteinizing hormone beta and Mllerian inhibiting substance ( MIS ) , requires SF 1 binding to DNA and appears to result from direct physical interaction between these two proteins . 0.55013672^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.90286971 |
| Additional binding studies indicated that protein interactions between SF 1 , Pitx 1 , and Egr 1 interfere with formation of a binary complex that contains AR and SF 1 . 0.90286971^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| The pan pituitary activator of transcription , Ptx 1 ( pituitary homeobox 1 ) , acts in synergy with SF 1 and Pit 1 and is an upstream regulator of the Lim homeodomain gene Lim3 / Lhx3 . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| One of these factors , pituitary homeobox 1 ( Pitx 1 ) , has been shown to stimulate LHbeta gene promoter activity , both alone and in synergy with the orphan nuclear receptor , steroidogenic factor 1 ( SF 1 ) , and the early growth response gene 1 ( Egr 1 ) . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| Transcription of mammalian LH beta subunit genes ( LHbeta ) is regulated by GnRH through activation of early growth response factor 1 ( Egr 1 ) , which interacts synergistically with steroidogenic factor 1 ( Sf 1 ) and pituitary homeobox 1 ( Pitx 1 ) at the promoter ; Egr 1 is thought to comprise the major mediator of this effect . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| A number of transcription factors evidenced in the pituitary may play a part in the development of this gland , namely Pit 1 , Prop 1 , P Lim , Ptx 1 , Rpx , Dax 1 , SF 1 . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| Egr 1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx 1 and SF 1 to enhance luteinizing hormone beta gene transcription . ^^^ Recent studies have identified key factors involved in luteinizing hormone beta ( LHbeta ) gonadotropin gene transcription : the nuclear receptor SF 1 , the bicoid related homeoprotein Ptx 1 ( Pitx 1 ) , and the immediate early Egr 1 gene . ^^^ We now show that GnRH is a potent stimulator of Egr 1 , but not Ptx 1 or SF 1 , expression . ^^^ Egr 1 interacts directly with Ptx 1 and with SF 1 , leading to an enhancement of Ptx 1 and SF 1 induced LHbeta transcription . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| In particular , Ptx 1 contributes to promoter and lineage specific transcription by interaction with cell restricted factors such as SF 1 , Egr 1 , Pit 1 , and the basic helix loop helix heterodimer NeuroD1 / Pan1 . ^^^ Also like Ptx 1 , the Ptx1b , Ptx2a , and Ptx2b transcription factors synergize with the structurally unrelated factors SF 1 , Egr 1 , Pit 1 , and NeuroD1 / Pan1 to activate promoter specific transcription . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| Tandem copies of regulatory elements that bind early growth response protein 1 ( Egr 1 ) and steroidogenic factor 1 ( SF 1 ) are located in the proximal region of the LHbeta promoter and make essential contributions to its activity as well as mediate responsiveness to GNRH : Located between these tandem elements is a single site capable of binding the homeodomain protein Pitx 1 . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| These include Sf 1 and Pitx 1 as in mammals , but the function of the Egr 1 appears to have been replaced by the estrogen receptor ( ER ) . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| The LHbeta promoter is regulated by the orphan nuclear receptor SF 1 and homeodomain protein Ptx 1 . ^^^ Therefore , we examined whether MIP 2A can modulate SF 1 and Ptx 1 mediated transcriptional activation . ^^^ Our results suggested that MIP 2A expression inhibits SF 1 and Ptx 1 mediated transactivation of LHbeta promoter . ^^^ Subsequent analysis demonstrated that MIP 2A physically interacts with both SF 1 and Ptx 1 , thereby inhibiting transactivation of the LHbeta promoter . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| Recently , many transcription factors , such as early growth response 1 ( Egr 1 ) , steroidogenic factor 1 ( SF 1 ) , Ptx 1 and Sp 1 , have been recognized to be involved in expression of the LHbeta gene through binding to the promoter region of LHbeta gene . . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that ERalpha can associate with the LHbeta promoter through interactions with Sf 1 and Pitx 1 without requiring an estrogen response element ( ERE ) . ^^^ |
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| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and Q13285 |
Pubmed |
SVM Score :0.0 |
| NA |
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