| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.59993619 |
| Egr 1 interacts directly with Ptx 1 and with SF 1 , leading to an enhancement of Ptx 1 and SF 1 induced LHbeta transcription . 0.59993619^^^ |
|
| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.53756003 |
| In contrast , functional interaction between Pitx 1 and Egr 1 persisted with mutation of both Pitx 1 regions . 0.53756003^^^ |
|
| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| In particular , Ptx 1 contributes to promoter and lineage specific transcription by interaction with cell restricted factors such as SF 1 , Egr 1 , Pit 1 , and the basic helix loop helix heterodimer NeuroD1 / Pan1 . ^^^ Also like Ptx 1 , the Ptx1b , Ptx2a , and Ptx2b transcription factors synergize with the structurally unrelated factors SF 1 , Egr 1 , Pit 1 , and NeuroD1 / Pan1 to activate promoter specific transcription . ^^^ |
|
| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| Tandem copies of regulatory elements that bind early growth response protein 1 ( Egr 1 ) and steroidogenic factor 1 ( SF 1 ) are located in the proximal region of the LHbeta promoter and make essential contributions to its activity as well as mediate responsiveness to GNRH : Located between these tandem elements is a single site capable of binding the homeodomain protein Pitx 1 . ^^^ |
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| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| Sp 1 and early growth response protein 1 play pivotal roles in GnRH stimulated LHbeta gene expression in synergism with steroidogenic factor 1 and Ptx 1 . ^^^ |
|
| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| These include regulatory elements that bind steroidogenic factor 1 ( SF 1 ) , Egr 1 , and Pitx 1 . ^^^ When tested by cotransfection with AR , overexpression of Egr 1 , Pitx 1 , and constitutively active steroidogenic factor 1 ( SF 1DeltaLBD ) each individually rescued androgen mediated suppression of the bovine LHbeta promoter . ^^^ Additional binding studies indicated that protein interactions between SF 1 , Pitx 1 , and Egr 1 interfere with formation of a binary complex that contains AR and SF 1 . ^^^ |
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| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| These include Sf 1 and Pitx 1 as in mammals , but the function of the Egr 1 appears to have been replaced by the estrogen receptor ( ER ) . ^^^ |
|
| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| Recently , many transcription factors , such as early growth response 1 ( Egr 1 ) , steroidogenic factor 1 ( SF 1 ) , Ptx 1 and Sp 1 , have been recognized to be involved in expression of the LHbeta gene through binding to the promoter region of LHbeta gene . . ^^^ |
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| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| Transcription of mammalian LH beta subunit genes ( LHbeta ) is regulated by GnRH through activation of early growth response factor 1 ( Egr 1 ) , which interacts synergistically with steroidogenic factor 1 ( Sf 1 ) and pituitary homeobox 1 ( Pitx 1 ) at the promoter ; Egr 1 is thought to comprise the major mediator of this effect . ^^^ |
|
| Interacting proteins: P78337 and P18146 |
Pubmed |
SVM Score :0.0 |
| NA |
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