In addition to Zap 70 , the 3BP2 SH 2 domain associated in vitro with LAT , Grb 2 , PLCgamma 1 , and Cbl from activated T cell lysates . ^^^ Thus , 3BP2 is an important adaptor that may couple activated Zap 70 / Syk to a LAT containing signaling complex involved in TCR mediated gene transcription . . ^^^