| Interacting proteins: P78314 and O43561 |
Pubmed |
SVM Score :0.0 |
| In addition to Zap 70 , the 3BP2 SH 2 domain associated in vitro with LAT , Grb 2 , PLCgamma 1 , and Cbl from activated T cell lysates . ^^^ Thus , 3BP2 is an important adaptor that may couple activated Zap 70 / Syk to a LAT containing signaling complex involved in TCR mediated gene transcription . . ^^^ |
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| Interacting proteins: P78314 and O43561 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
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| Interacting proteins: P78314 and O43561 |
Pubmed |
SVM Score :0.0 |
| Furthermore , antigen stimulation induced the association of 3BP2 SH 2 domain with LAT and other signaling molecule complexes in the RBL 2H3 cells . ^^^ |
|
| Interacting proteins: P78314 and O43561 |
Pubmed |
SVM Score :0.0 |
| Furthermore , point mutation of Arg ( 486 ) in the 3BP2 SH 2 domain that couples ZAP 70 to LAT dramatically reduces NFAT activation . ^^^ |
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