Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.71237648
ROC 1 , a novel SCF associated protein , is recruited by cullin 1 to form a quatemary SCFHOS ROC 1 holenzyme ( with Skp 1 and the beta TRCP homolog HOS ) . 0.71237648^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF is composed of a cullin ( Cdc 53 ) , SKP 1 , RBX 1 and one member of a large family of proteins called F box proteins . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
TIP120A formed a complex with CUL 1 and Rbx 1 , but interfered with the binding of Skp 1 and F box proteins to CUL 1 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
We demonstrate that p 185 forms an SCF like complex with Skp 1 , Rbx 1 , Fbw 6 ( Fbx 29 ) , and FAP 68 ( FAP 48 , glomulin ) . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
We found the majority of CUL 1 is in a complex with CAND 1 and ROC 1 independent of SKP 1 and F box protein SKP 2 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
SCF is a ubiquitin ligase and is composed of Skp 1 , Cul 1 , F box protein , and Roc 1 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Atrogin 1 associates with Skp 1 , Cul 1 , and Roc 1 to assemble an SCF ( atrogin 1 ) complex with ubiquitin ligase activity . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
SCF complexes consist of three invariable components , Skp 1 , Cul 1 ( Cdc 53 in yeast ) and Rbx 1 , and a variable F box protein that recruits a specific cellular protein to the ubquitin pathway for degradation . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The other three subunits are the Skp 1 protein ; one of the cullin proteins ( Cul 1 in metazoans and Cdc 53 or Cul A in the yeast Saccharomyces cerevisiae ) ; and the recently identified Roc 1 protein ( also called Rbx 1 or Hrt 1 ) . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Skp 1 binding links the F box protein with a core ubiquitin ligase composed of the proteins Cdc53 / Cul1 , Rbx 1 ( also called Hrt 1 and Roc 1 ) and the E 2 ubiquitin conjugating enzyme Cdc 34 [ 8 ] [ 9 ] [ 10 ] [ 11 ] . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Each SCF complex is composed of the core protein subunits Skp 1 , Rbx 1 and Cul 1 ( known as Cdc 53 in yeast ) , and substrate specific adaptor subunits called F box proteins [ 2 ] [ 3 ] [ 4 ] . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Analysis of the mechanisms of phosphorylation directed proteolysis in cell cycle regulation has uncovered a new class of E 3 ubiquitin ligases called SCF complexes , which are composed of the subunits Skp 1 , Rbx 1 , Cdc 53 and any one of a large number of different F box proteins . ^^^ The substrate specificity of SCF complexes is determined by the interchangeable F box protein subunit , which recruits a specific set of substrates for ubiquitination to the core complex composed of Skp 1 , Rbx 1 , Cdc 53 and the E 2 enzyme Cdc 34 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF complex is a type of ubiquitin ligase that consists of the invariable components SKP 1 , CUL 1 , and RBX 1 as well as a variable component , known as an F box protein , that is the main determinant of substrate specificity . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF complex is a type of ubiquitin protein ligase ( E 3 ) that consists of invariable components , including Skp 1 , Cdc53 / Cul1 , and Rbx 1 , as well as variable components known as F box proteins . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
In yeast and mammals , the SCF complex consists of common components , including Skp 1 , Cdc53 / Cul1 , and Rbx 1 , as well as variable components known as F box proteins . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Despite being unusual in having localized transcripts , we found that the Drosophila and zebrafish homologs interact with the expected Drosophila components of the cellular degradation machinery Skp 1 ( SkpA ) and Rbx 1 ( Roc1a ) suggesting that the Ppa proteins are indeed functional F box proteins . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF complex , which consists of the invariable components Skp 1 , Cul 1 , and Rbx 1 as well as a variable F box protein , functions as an E 3 ubiquitin ligase . ^^^ Immunoprecipitation , immunoblot , and immunofluorescence analyses with mammalian cells revealed that TIP120A physically associates with Cul 1 in the nucleus and that this interaction is mediated by a central region of Cul 1 distinct from its binding sites for Skp 1 and Rbx 1 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Moreover , cDNA array analysis showed that PC SPES caused up regulation of p 21 ( WAF1 / CIP1 ) and decreased expression of cyclin B , Nedd 8 , cdc 2 , skp 1 , PCNA , MAD2L1 , cyclin H , CKS 2 , E2F , Rbx 1 , MCM 2 , MCM 5 , Mpp 2 , Cullin Cul4A , Cks1p9 and McM 7 , which are involved in cell cycle progression . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Among the four components of the SCF complexes , Rbx 1 and Cullin form a core catalytic complex , an F box protein acts as a receptor for target proteins , and Skp 1 is an adaptor between one of the variable F box proteins and Cullin . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF core components Skp 1 , Cul 1 , and Rbx 1 serve in multiple SCF complexes involving different substrate specific F box proteins that are involved in diverse processes including cell cycle and development . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Skp 1 , Cullin , F box ( SCF ) complexes are one influential E 3 class that use F box proteins to deliver targets to a core ligase activity provided by the Skp 1 , Cullin , and Rbx 1 subunits . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
It has been shown that T Ag associates with an SCF like complex that contains a member of the cullin family of E 3 ubiquitin ligases , CUL 7 , as well as SKP 1 , RBX 1 , and an F box protein , FBXW 8 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF ( Skp 2 ) complex ( consisting of Rbx 1 , Cul 1 , Skp 1 , and Skp 2 ) is one of the E 3 ubiquitin ligases involved in ubiquitination of p 21 ( Cip1 / WAF1 ) . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF complexes are organized by the elongated scaffold protein subunit Cul 1 , which interacts with the Rbx 1 RING finger protein at one end and the Skp 1 adaptor protein at the other . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The initial ubiquitin transfer and subsequent polymerization steps of this reaction require the coordinated action of Cdc 34 and the SCF ( HOS / beta TRCP ) ROC 1 E3 ligase complex , comprised of four subunits ( Skp 1 , cullin 1 [ CUL 1 ] , HOS / beta TRCP , and ROC 1 ) . ^^^ Deletion analysis reveals that the N terminus of CUL 1 is both necessary and sufficient for binding Skp 1 but is devoid of ROC 1 binding activity and , hence , is inactive in catalyzing ubiquitin ligation . ^^^ These results suggest the mode of action of SCF ROC 1 , where CUL 1 serves as a dual function molecule that recruits an F box protein for substrate targeting through Skp 1 at its N terminus , while the C terminus of CUL 1 binds ROC 1 to assemble a core ubiquitin ligase . . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The SCF ( Fbw 1 ) ( composed of Skp 1 , Cul 1 , Roc 1 , and Fbw 1 ) complex , identified as an IkappaBalpha E 3 ligase , binds and ubiquitylates IkappaBalpha phosphorylated by IkappaB kinase that has been activated in response to extracellular signals . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
An E 3 ubiquitin ligase complex ROC 1 SCF ( Fbw1a ) consisting of ROC 1 , Skp 1 , Cullin 1 , and Fbw1a ( also termed betaTrCP 1 ) induces ubiquitination of Smad 3 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
NEDD 8 is known to enhance the ubiquitylating activity of the SCF complex ( composed of Skp 1 , Cul 1 , ROC 1 and F box protein ) , but the mechanistic role is largely unknown . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
It contains a functional F box domain that binds to Skp 1 and thereby to Roc 1 and Cul 1 , the other components of SCF type Ub protein ligases ( E3s ) , as well as a nuclear localization sequence and PDZ binding domain . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
The hFBH 1 enzyme interacted with human SKP 1 and formed an SCF ( SKP1 / Cullin / F box ) complex together with human Cullin and ROC 1 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Remarkably , CUL 7 assembles an SCF ROC 1 like E 3 ubiquitin ligase complex consisting of Skp 1 , CUL 7 , the Fbx 29 F box protein , and ROC 1 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
An activated SCF complex , a heterotetramer ( Skp 1 , Cul 1 , beta TrCP [ F box protein ] , and ROC 1 ) involved with ubiquitination , is also required for iNOS NO ( . ) induction . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Cul 1 associates with one of many F box proteins through Skp 1 to assemble various SCF Roc 1 E3 ligases that each selectively ubiquitinate one or more specific substrates . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
In our previous study , we found that a human F box DNA helicase , named hFBH 1 , interacted with SKP 1 to form an SCF ( SKP 1 Cul1 F box protein ) complex together with CUL 1 and ROC 1 in an F box dependent manner . ^^^ In this report , we characterized the enzymatic properties of the recombinant SCF ( hFBH 1 ) complex purified from insect cells expressing hFBH 1 , SKP 1 , CUL 1 and ROC 1 . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Cul family proteins are scaffold proteins for a wide series of ubiquitin protein ligase complexes , such as SCFs ( Skp 1 , Cul 1 , Roc 1 , and F box proteins ) , which regulate the degradation of broad range of cellular proteins . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
CUL 7 assembles an E 3 ubiquitin ligase complex containing Skp 1 , Fbx 29 ( also called Fbw 8 ) and ROC 1 and promotes ubiquitination . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
FBXO 31 contains an F box domain and is associated with the proteins Skp 1 , Roc 1 , and Cullin 1 , suggesting that FBXO 31 is a component of a SCF ubiquitination complex . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
FBXO 25 was shown here to contain a functional F box domain that binds to Skp 1 and thereby to Roc 1 and Cul 1 , the major components of SCF type E3s . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
Ubiquitination of p 27 ( kip 1 ) is performed by the SCF ( skp 2 ) ubiquitin ligase comprised of the core components Roc 1 , Cul 1 and Skp 1 and the substrate recognition components Skp 2 and Cks 1 . ^^^ Here we show that in primary human T lymphocytes , the SCF ( skp 2 ) core components Roc 1 , Cul 1 and Skp 1 are constitutively expressed , and their levels remain unchanged upon TCR / CD3 plus CD 28 costimulation . ^^^
Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
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Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
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Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
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Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
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Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
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Interacting proteins: P62877 and P63208	Pubmed	SVM Score :0.0
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