| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| HOS , a human homolog of Slimb , forms an SCF complex with Skp 1 and Cullin 1 and targets the phosphorylation dependent degradation of IkappaB and beta catenin . ^^^ Being a part of SCF complex with Skp 1 and Cullin 1 , HOS specifically interacted with the phosphorylated IkappaB and beta catenin , targeting these proteins for proteasome dependent degradation in vivo . ^^^ |
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| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| Here we show that phosphorylated beta catenin is specifically recognized by beta Trcp , an F box / WD40 repeat protein that also associates with Skp 1 , an essential component of the ubiquitination apparatus . beta catenin harboring mutations at the critical phosphoserine residues escapes recognition by beta Trcp , thus providing a molecular explanation for why these mutations cause beta catenin accumulation that leads to cancer . ^^^ |
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| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| By engineering a chimeric protein with the beta catenin binding domain of E cadherin fused to betaTrCP ubiquitin protein ligase , the stable beta catenin mutant was recruited to the cellular SCF ( Skp 1 , Cullin 1 , and F box containing substrate receptor ) ubiquitination machinery for ubiquitination and degradation . ^^^ |
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| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| Siah interacting protein ( SIP ) was identified as a novel adaptor that physically links the E 3 ubiquitin ligase activity of Siah 1 with Skp 1 and Ebi F Box protein in the degradation of beta catenin , a transcriptional activator of TCF / LEF genes . ^^^ |
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| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| Later , it was found that CacyBP / SIP interacted with Siah 1 and Skp 1 and that it was involved in the ubiquitination and degradation of an oncogen , namely beta catenin . ^^^ |
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| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| Previously , we discovered a novel pathway for p 53 induced beta catenin degradation through a ubiquitin E 3 ligase complex involving Siah 1 , SIP ( CacyBP ) , Skp 1 , and Ebi . ^^^ |
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| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|