| Interacting proteins: P20248 and P63208 |
Pubmed |
SVM Score :0.0 |
| In normal and transformed cells , the F box protein p 45 ( SKP 2 ) is required for S phase and forms stable complexes with p 19 ( SKP 1 ) and cyclin A cyclin dependent kinase ( CDK ) 2 . ^^^ CUL 1 also associates with cyclin A and p 19 ( SKP 1 ) in vivo and , with p 45 ( SKP 2 ) , they assemble into a large multiprotein complex . ^^^ Finally , we show that multiprotein complex formation involving p 45 ( SKP 2 ) CUL 1 and p 19 ( SKP 1 ) is governed , in part , by periodic , S phase specific accumulation of the p 45 ( SKP 2 ) subunit and by the p 45 ( SKP 2 ) bound cyclin A CDK 2 . ^^^ The dependency of p 45 ( SKP 2 ) p 19 ( SKP 1 ) complex formation on cyclin A CDK 2 may ensure tight coordination of the activities of the cell cycle clock with those of a potential ubiquitin conjugation pathway . . ^^^ |
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| Interacting proteins: P20248 and P63208 |
Pubmed |
SVM Score :0.0 |
| Human CUL 1 , but not other cullin family members , selectively interacts with SKP 1 to form a complex with SKP 2 and cyclin A . ^^^ |
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| Interacting proteins: P20248 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20248 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20248 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|