| Interacting proteins: P08238 and P63208 |
Pubmed |
SVM Score :0.0 |
| By pathway specific cDNA microarray analysis , we found that BC 2 cells express high levels of egr 1 , ATF 2 , hsp 27 , hsp 90 , IkappaB , mdm 2 , skp 1 , and IL 2 , cellular genes involved in mitogenesis , tumorigenesis , and inhibition of apoptosis in NFkappaB and p 53 signaling pathways . ^^^ Furthermore , we found that MAP 30 downregulates the expression of egr 1 , ATF 2 , hsp 27 , hsp 90 , IkappaB , mdm 2 , and Skp 1 , while it upregulates the pro apoptotic related genes Bax , CRADD , and caspase 3 . ^^^ |
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| Interacting proteins: P08238 and P63208 |
Pubmed |
SVM Score :0.0 |
| Several lines of evidence support this conclusion : activation of heterologous Ctf13p / Skp1p by reticulocyte lysate is inhibited by geldanamycin and Hsp 90 depletion . skp 1 mutants exhibit growth defects on media containing geldanamycin . ^^^ A skp 1 mutation together with Hsp 90 mutations exhibits synthetic lethality . ^^^ |
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| Interacting proteins: P08238 and P63208 |
Pubmed |
SVM Score :0.0 |
| We also have determined that Skp 1 and Hsc 82 ( a yeast Hsp 90 protein ) bind to the N terminal region of Sgt 1 that contains tetratricopeptide repeat motifs . ^^^ We found that Hsp 90 ' s binding to Sgt 1 stimulates the binding of Sgt 1 to Skp 1 and that Sgt 1 and Hsp 90 stimulate the binding of Skp 1 to Ctf 13 , the F box core kinetochore protein . ^^^ Our results strongly suggest that Sgt 1 and Hsp 90 function in assembling CBF 3 by activating Skp 1 and Ctf13 . . ^^^ |
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| Interacting proteins: P08238 and P63208 |
Pubmed |
SVM Score :0.0 |
| Through interacting with suppressor of the G 2 allele of Skp 1 ( SGT 1 ) and Hsp 90 , plant CHORD containing protein RAR 1 ( required for Mla resistance 1 ) plays a critical role in disease resistance mediated by multiple R genes . ^^^ |
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| Interacting proteins: P08238 and P63208 |
Pubmed |
SVM Score :0.0 |
| We found that HSP 90 associates with SGT 1 ( suppressor of G 2 allele of skp 1 ; SUGT 1 ) in human cells and that depletion of SGT 1 sensitizes HeLa cells to 17 AAG . ^^^ |
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