| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.87304363 |
| In this report , we identify this 100 kDa protein as the recently cloned scaffolding protein Gab 2 , and we demonstrate that Gab 2 associates with several molecules involved in M CSF signaling , including Grb 2 , SHP 2 , the p 85 subunit of phosphatidylinositol 3 ' kinase , SHIP , and SHC . 0.87304363^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.97990088 |
| As in other cells , Gab 2 was found to associate with several signaling molecules including Src homology 2 containing protein tyrosine phosphatase 2 , Grb 2 , Lyn , and phospholipase C gamma ( PLC gamma ) . 0.97990088^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Identification of Grb 2 associated binder 2 as the major mediator in rat hepatocytes . ^^^ We therefore cloned a cDNA from rat liver , which was found to be 95 % homologous to the mouse Grb 2 associated binder 2 ( Gab 2 ) cDNA sequence . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| RESULTS : A GST fusion containing the C terminal SH 3 domain of Grb 2 bound to the nucleotide exchange factor Sos or Grb 2 associated binder 2 ( Gab 2 ) . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 associated binder 2 ( Gab 2 ) , a member of the Dos / Gab subfamily scaffolding molecules , plays important roles in regulating the growth , differentiation , and function of many hematopoietic cell types . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| We identify the adaptor protein Grb 2 associated binder 2 ( Gab 2 ) as a direct E2F target gene and an essential effector of E2F dependent AKT activation . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Scaffolding adapter Grb 2 associated binder 2 requires Syk to transmit signals from FcepsilonRI . ^^^ Scaffolding adapter Grb 2 associated binder 2 ( Gab 2 ) is a key component of FcepsilonRI signaling in mast cells , required for the activation of PI3K . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Upon tyrosine phosphorylation , Gab 2 physically interacts with Shp 2 tyrosine phosphatase and Grb 2 adapter protein . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Gab 1 and Gab 2 ( Grb 2 associated binder 1 and 2 ) are scaffolding adapter molecules that display sequence similarity with Drosophila DOS ( daughter of sevenless ) , which is a potential substrate for the protein tyrosine phosphatase , Corkscrew , Both Gab 1 and Gab 2 , like DOS , have a pleckstrin homology domain and potential binding sites for SH 2 and SH 3 domains . ^^^ Gab 1 and Gab 2 are phosphorylated on tyrosine upon the stimulation of various cytokines , growth factors , and antigen receptors , and interact with signaling molecules , such as Grb 2 , SHP 2 , and PI 3 kinase . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| To determine the requirement for Grb 2 in Gab 1 recruitment , we have mapped two Grb 2 carboxyl terminal SH 3 domain binding sites conserved in Gab 1 and related protein Gab 2 . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Mutation of the three tyrosyl phosphorylation sites of Shc , which bind Grb 2 , blocks the ability of the Shc chimera to evoke Gab 2 tyrosyl phosphorylation . ^^^ Overexpression of mutants of Grb 2 with inactive SH 2 or SH 3 domains also blocks cytokine stimulated Gab 2 phosphorylation . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Ligand stimulation of neuronal cells induced the assembly of a large protein complex containing c Ret , Grb 2 , and tyrosine phosphorylated forms of Shc , p 85 ( PI3K ) , the adaptor Gab 2 , and the protein tyrosine phosphatase SHP 2 . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Flt 3 ligand induces tyrosine phosphorylation of gab 1 and gab 2 and their association with shp 2 , grb 2 , and PI 3 kinase . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Expression of Deltap 85 led to a reduction in SHP 2 tyrosine phosphorylation and its ability to interact with Grb 2 and Gab 2 but increased overall tyrosine phosphorylation of Gab 2 . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that upon thrombopoietin ( Tpo ) stimulation the two adapter proteins Gab 1 and Gab 2 are strongly tyrosine phosphorylated and associated with Shc , SHP 2 , PI 3 kinase and Grb 2 in mpl expressing UT 7 cells . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Gab 2 in K 562 cells resulted in transcriptional activation of the c fos serum response element ( SRE ) promoter , whereas overexpression of SHP 2 , Grb 2 , and CrkL had no effect . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| We show that Gab 2 recruitment to the Met receptor is dependent on the Grb 2 adapter protein . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| The signaling proteins , Vav , Grb 2 , Cbl and Gab 2 , and the endocytic proteins , AP 2 and clathrin , all map to the primary domains , while the p 85 regulatory subunit of phosphatidylinositol 3 ( PI 3 ) kinase maps to both domains . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Gab 1 and Gab 2 are scaffolding proteins acting downstream of cell surface receptors and interact with a variety of cytoplasmic signaling proteins such as Grb 2 , Shp 2 , phosphatidylinositol 3 kinase , Shc , and Crk . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Although phosphorylation of Gab 2 was similar in WT and mutant cell lines , phosphorylation of Shc on Tyr ( 313 ) in response to IGF 1 was decreased in cells expressing the mutant receptor , as was recruitment of Grb 2 and Ship to Shc . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| A Tel Abl point mutant ( Y314F ) and a splice variant without TEL exon 5 sequences ( Deltae 5 ) lacked Grb 2 interaction and exhibited decreased binding and phosphorylation of the scaffolding protein Gab 2 and impaired activation of phosphatidylinositol 3 kinase , Akt , and extracellular signal regulated kinase / mitogen activated protein kinase in hematopoietic cells . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| We show in the present study that the scaffolding protein Gab 2 [ Grb 2 ( growth factor receptor bound protein 2 ) associated binder 2 ] is an essential component of this interaction . ^^^ Gab 2 is persistently tyrosine phosphorylated in Ba / F3 cells expressing caSTAT 5 ( constitutively activated STAT 5 ) , independent of JAK 2 ( Janus kinase 2 ) activation where it interacts with STAT 5 , p 85 and Grb 2 , but not with Shp 2 [ SH 2 ( Src homology 2 ) domain containing tyrosine phosphatase ] proteins . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| The interaction between p85alpha SH 3 and BCR / ABL may be intermediated by proteins such as c Cbl , Shc , Grb 2 , and / or Gab 2 . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Under these conditions , Gab 2 increased cell proliferation during morphogenesis , leading to significantly larger acini , an effect dependent on Gab 2 binding to Grb 2 and Shp 2 and enhanced by recruitment of the p 85 subunit of phosphatidylinositol 3 kinase . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein Gab 2 coordinates the assembly of the IL 3 signalsome comprising Gab 2 , Grb 2 , Shc , SHP 2 and PI3K . ^^^ |
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| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| GRB 2 mediated recruitment of GAB 2 , but not GAB 1 , to SF STK supports the expansion of Friend virus infected erythroid progenitor cells . ^^^ A fusion protein in which the Grb 2 binding site in Sf Stk is replaced by Gab 2 , supports the growth of progenitors from mice lacking Sf Stk , whereas a Sf Stk / Gab1 fusion protein does not . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| The E76K mutation in the N terminal Src homology 2 domain increased interactions of mutant SHP 2 with Grb 2 , Gab 2 , and p 85 , leading to hyperactivation of IL 3 induced Erk and phosphatidylinositol 3 kinase ( PI3K ) pathways . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| The Grb 2 associated binder ( Gab ) adaptor / scaffolding protein family comprises conserved proteins : mammalian Gab 1 , Gab 2 and Gab 3 , Drosophila Dos and Caenorhabditis elegans Soc 1 . ^^^ |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|