| Magicin , a novel cytoskeletal protein associates with the NF 2 tumor suppressor merlin and Grb 2 . ^^^ We report a novel protein as a merlin specific binding partner that we have named magicin ( merlin and Grb 2 interacting cytoskeletal protein ) and show that the two proteins interact in vitro and in vivo as well as colocalize beneath the plasma membrane . ^^^ Analysis of the magicin sequence reveals binding motifs for the adaptor protein Grb 2 . ^^^ Employing affinity binding , blot overlay and co immunoprecipitation assays , we demonstrate an interaction between Grb 2 and magicin . ^^^ In addition , merlin is capable of forming a ternary complex with magicin and Grb 2 . ^^^ |