| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.69267135 |
| In FGF 2 treated proliferating EC , FRS 2 as well as Shc are tyrosine phosphorylated and interact with Grb 2 . 0.69267135^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :1.2121124 |
| Furthermore , Grb 2 bound to tyrosine phosphorylated FRS 2 through its SH 2 domain interacts primarily via its carboxyl terminal SH 3 domain with a proline rich region in Gab 1 and via its amino terminal SH 3 domain with the nucleotide exchange factor Sos 1 . 1.2121124^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.77094179 |
| Here , we demonstrate that Grb 2 bound to tyrosine phosphorylated FRS 2 alpha forms a ternary complex with Cbl by means of its Src homology 3 domains resulting in the ubiquitination of fibroblast growth factor ( FGF ) receptor and FRS 2 alpha in response to FGF stimulation . 0.77094179^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| We found that both FGFR substrate 2 and Grb 2 play important roles in NCAM as well as in FGF 2 stimulated events . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Two classes of differentiation factors , the neurotrophins and fibroblast growth factors , induce rapid tyrosine phosphorylation of SNT 1 ( FRS2alpha ) , which in turn enables SNT 1 to recruit Shp 2 tyrosine phosphatase and Grb 2 adaptor protein in complex with the Ras GDP / GTP exchange factor Sos . ^^^ Mutagenesis of SNT 1 ( IRS ) CX identified three classes of effector motifs within SNT critical for both sustained ERK activation and neuronal differentiation : 1 ) four phosphotyrosine motifs that mediate recruitment of Grb 2 , 2 ) two phosphotyrosine motifs that mediate recruitment of Shp 2 , and 3 ) a C terminal motif that functions by helping to recruit Sos . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| In addition , a mutant FRS 2 deficient in both Grb 2 and Shp 2 binding induces a weak and transient MAP kinase response and fails to induce PC 12 cell differentiation in response to FGF stimulation . ^^^ These experiments demonstrate that FRS 2 recruits Grb 2 molecules both directly and indirectly via complex formation with Shp 2 and that Shp 2 plays an important role in FGF induced PC 12 cell differentiation . . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Analysis of proteins implicated in FGFR 1 signalling indicates that upon stimulation , a tyrosine phosphorylated protein designated FRS 2 associates with SOS , Grb 2 and the receptor . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Consistent with this model , FRS 2 binds Grb 2 , Crk , the SH 2 domain containing tyrosine phosphatase SH PTP 2 , the cyclin dependent kinase substrate p 13 ( suc 1 ) , and the Src homology 3 ( SH 3 ) domain of Src , providing a functional link between TrkA , cell cycle , and multiple NGF signaling effectors . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Data are presented demonstrating that BDNF induces association of FRS 2 with growth factor receptor binding protein 2 ( GRB 2 ) in cortical neurons , fibroblasts , and NB cells , which in turn could activate the RAS / MAPK pathway . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 binding to TrkA is independent of Shc , FRS 2 , phospholipase Cgamma 1 , rAPS , and SH2B and is observed in in vitro binding assays , yeast two hybrid assays , and in co immunoprecipitation assays . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| The specific effect of LAR on FGF induced MAPK activation appeared to be mediated by specific inhibition of the phosphorylation of two signal transducers that act downstream of the FGF receptor , FRS 2 and a 180 kDa protein , and by prevention of their interaction with the adaptor protein GRB 2 . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| FRS 2 has been identified in mammalian cells as a protein that is tyrosine phosphorylated and binds to Grb 2 and Shp 2 in response to fibroblast growth factor ( FGF ) or nerve growth factor ( NGF ) stimulation . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| VEGF treatment of KDR expressing cells leads to the recruitment of Nck , p 21 activated kinase , Crk , Grb 2 , and protein kinase C l to FRS 2 . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Next , they bind to the adaptor protein Grb 2 and inhibit the recruitment of the Grb 2 Sos complex either to the fibroblast growth factor receptor ( FGFR ) docking adaptor protein FRS 2 or to Shp 2 . ^^^ A tyrosine phosphorylated octapeptide derived from mouse Spry 2 inhibits Grb 2 from binding FRS 2 , Shp 2 or mouse Spry 2 in vitro and blocks activation of the extracellular signal regulated kinase ( ERK ) in cells stimulated by growth factor . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| However , the C / S SHP 2 protein did not show any effect on receptor autophosphorylation , FRS 2 tyrosine phosphorylation or interaction of Grb 2 with K / E FR 3 or FRS 2 . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| We found that the MAPK pathway protein set consisting of the following gene products was present : FRS 2 alpha , GRB 2 , GAB 1 , SOS 1 , Ha ras , Raf1 / RafB , MEK 1 , 2 , 5 , MAPK / ERK1 , 2 , MAPK / ERK5 , and RSK 1 , 2 , 3 ( see abbreviations ) . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| The intracellular pathways used by neurotrophins share many common protein substrates that are used by other receptor tyrosine kinases ( RTK ) , such as Shc , Grb 2 , FRS 2 , and phospholipase C gamma . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Previously , we had found that the phosphorylation of FRS 2 induces association of FRS 2 and growth factor receptor binding protein 2 ( Grb 2 ) . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| After FGF stimulation , tyrosine phosphorylated FRS2alpha recruits four molecules of the adaptor protein Grb 2 and two molecules of the protein tyrosine phosphatase Shp 2 , resulting in activation of the Ras / extracellular signal regulated kinase ( ERK ) and phosphatidylinositol 3 kinase / Akt signaling pathways . ^^^ In this report , we explore the role of signaling pathways downstream of FRS2alpha in eye development by analyzing the phenotypes of mice that carry point mutations in either the Grb 2 ( Frs2alpha ( 4F ) ) or the Shp 2 binding sites ( Frs2alpha ( 2F ) ) of FRS2alpha . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| These included FRS2alpha , GAB 1 , GRB 2 , SOS 1 , Raf B , and Raf 1 . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| FRS2alpha mediates many of its pleiotropic cellular responses by recruiting the adaptor protein Grb 2 and the protein tyrosine phosphatase Shp 2 upon ligand stimulation . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| Suc 1 associated neurotrophic factor target ( SNT ) protein is a major FGF stimulated tyrosine phosphorylated 90 kDa protein which binds to the SH 2 domain of GRB 2 . ^^^ Tyrosine phosphorylated SNT binds to both p13suc1 protein and the SH 2 domain of Grb 2 . ^^^ Binding of SNT to Grb 2 is likely to be mediated through the consensus binding motif , pYXN , on SNT . ^^^ Tyrosine phosphorylated SNT is localised in the plasma membrane where it could form a complex with Grb 2 and Sos , enabling the initiation of a novel FGF specific signalling pathway . . ^^^ |
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| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|