| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| GRB 7 can also bind tyrosine phosphorylated SHC , albeit at a lower affinity than GRB 2 binds SHC . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Synthetic phosphorylated peptides containing Tyr 716 or Tyr 775 inhibited binding of the Grb 7 SH2 domain to the autophosphorylated PDGF beta receptor in a manner similar to but distinct from the binding of the Grb 2 SH2 domain . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphopeptide competition and site directed mutagenesis revealed that Tyr 1139 of erbB 2 is the major binding site for the Grb 7 SH2 domain , indicating an overlap in binding specificity between the Grb 7 and Grb 2 SH2 domains . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Although these recognition sequences possess an Asn residue at +2 relative to the phosphotyrosine and therefore represent potential Grb 2 binding sites , phosphopeptide competition and `` pull down ' ' experiments demonstrated that they interact preferentially with the Grb 7 versus the Grb 2 SH2 domain . ^^^ Consequently , the Grb 2 and Grb 7 SH2 domains possess overlapping , but distinct , specificities . ^^^ These studies therefore identify Grb 7 as an in vivo target of erbB 3 and erbB 4 and provide an underlying mechanism for the ability of erbB 3 to recruit Grb 7 and not Grb 2 , a property unique among erbB receptors . . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Some of these asterriquinones exhibited specific inhibition of Grb 2 binding compared to Grb 7 and PLC gamma . . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| We furthermore demonstrate that the adapter protein Grb 2 is a specific binding partner for both phosphorylated Tyr 703 and phosphorylated Tyr 936 , whereas the adapter protein Grb 7 binds selectively to phosphorylated Tyr 936 . ^^^ Identification of Tyr 703 and Tyr 936 as the primary association sites for Grb 2 and Grb 7 in the c Kit / stem cell factor receptor . ^^^ It is shown that the association occurs through the Src homology 2 ( SH 2 ) domains of Grb 2 and Grb 7 . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Using this approach , we demonstrate that five molecules , Grb 2 , Grb 7 , Grb 14 , Shp 2 , and the p 85 subunit of phosphatidylinositol 3 kinase can interact with Tek in a phosphotyrosine dependent manner through their SH 2 domains . ^^^ Mutation of this site abrogates binding of Grb 2 and Grb 7 to Tek in vivo , and this site is required for tyrosine phosphorylation of Grb 7 and p 85 in vivo . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of cell migration and cell cycle progression by FAK complexes with Src , PI3K , Grb 7 and Grb 2 in focal contacts . ^^^ We found that fusion of FAT to Src , the p 85 subunit of phosphatidylinositol 3 kinase , Grb 7 and Grb 2 resulted in the efficient focal adhesion targeting of these signaling molecules . ^^^ We showed that expression of Src FAT , p 85 FAT , or Grb 7 FAT , but not Grb 2 FAT , each stimulated cell migration . ^^^ In contrast , targeting of Grb 2 , but not Src , p 85 , or Grb 7 , to focal contacts increased cell cycle progression . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Investigation of the GRB 2 , GRB 7 , and CSH 1 genes as candidates for the Silver Russell syndrome ( SRS ) on chromosome 17q . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated that Tyr 936 is an autophosphorylation site involved in binding the adapter proteins Grb 2 and Grb 7 . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Stimulation of Kit by its ligand , stem cell factor activates several distinct early signaling pathways , including phospholipase C gamma , phosphatidylinositol 3 kinase , Src kinase , Grb 2 , and Grb 7 . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Adaptor signalling proteins Grb 2 and Grb 7 are recruited by human G6f , a novel member of the immunoglobulin superfamily encoded in the MHC . ^^^ This tyrosine residue is found in a consensus binding motif ( YXN ) for the Src homology 2 domains of Grb 2 and Grb 7 ( where Grb stands for growth factor receptor bound protein ) . ^^^ Glutathione S transferase pull down assays showed that the interaction of G6f with both Grb 2 and Grb 7 is mediated through the Src homology 2 domains of these two proteins and is dependent on the phosphorylation of G6f . ^^^ Immunoprecipitation experiments showed the interaction of full length phosphorylated G6f with both full length Grb 2 and Grb 7 . ^^^ These results suggest a coupling of G6f with downstream signal transduction pathways involving Grb 2 and Grb 7 , including the Ras MAP kinase pathway . . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation experiments demonstrated that NIK interacted with Grb 7 , as well as Grb 10 and Grb 14 , but not Grb 2 . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , restoring the binding sites for Grb 2 , Grb 7 , or phospholipase C gamma had no effect on cellular growth or survival , migration , or activation of any of the downstream signaling pathways . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphotyrosine 936 , also in the distal kinase domain , binds the adaptor proteins APS , Grb 2 , and Grb 7 . ^^^ |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|