| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| Sos , Vav , and C3G participate in B cell receptor induced signaling pathways and differentially associate with Shc Grb 2 , Crk , and Crk L adaptors . ^^^ Using the yeast two hybrid system and bacterial fusion proteins , Vav and C3G were identified as Grb 2 binders . ^^^ While Sos binds to both Grb 2 Src homology 3 ( SH 3 ) domains , Vav was found to associate selectively with the carboxyl terminal SH 3 domain , while C3G bound selectively to the amino terminal SH 3 domain of bacterially expressed Grb 2 . ^^^ C3G did not bind to either Grb 2 , Shc , or Crk in vivo . ^^^ |
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| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| Enhancement of guanine nucleotide exchange activity of C3G for Rap 1 by the expression of Crk , CrkL , and Grb 2 . ^^^ C3G also binds to other adaptor proteins , including CrkL and Grb 2 . ^^^ In the present study , we analyzed the effect of Crk , CrkL , and Grb 2 on the C3G Rap 1 pathway . ^^^ Expression of Crk , CrkL , and Grb 2 with C3G in Cos 1 cells significantly increased the ratio of GTP / GDP bound to Rap 1 . ^^^ These results demonstrate that Crk , CrkL , and Grb 2 positively modulate the C3G Rap 1 pathway primarily by recruiting C3G to the cell membrane . . ^^^ |
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| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^ |
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| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|