Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.83150866
Association of Gab 1 with Met requires a functional Grb 2 binding site involving tyrosine 1356 and to a lesser extent tyrosine 1349 . 0.83150866^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.61767856
The association of Gab 1 with Grb 2 is required for Gab 1 recruitment to the EGF receptor but not the Met receptor . 0.61767856^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :1.0793577
Gab 1 , a receptor tyrosine kinase substrate which associates with Grb 2 and the c Met receptor , was previously shown to bind Grb 2 via a region which lacks a Grb 2 SH3 ( N ) typical motif ( P 10 10 P 10 R ) . 1.0793577^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :1.2250499
Furthermore , Grb 2 bound to tyrosine phosphorylated FRS 2 through its SH 2 domain interacts primarily via its carboxyl terminal SH 3 domain with a proline rich region in Gab 1 and via its amino terminal SH 3 domain with the nucleotide exchange factor Sos 1 . 1.2250499^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.53938248
Whereas SHC bound to RET was associated with GRB 2 and GAB 1 proteins , SNT / FRS2 was associated with GRB 2 only , suggesting that SNT / FRS2 is involved mainly in the activation of the RAS / mitogen activated protein kinase ( MAPK ) pathway but not the phosphatidylinositol 3 kinase ( PI 3 K ) / AKT pathway . 0.53938248^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Here we use recombinant Grb 2 to isolate a complementary DNA called Gab 1 ( for Grb 2 associated binder 1 ) . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Determination of Gab 1 ( Grb 2 associated binder 1 ) interaction with insulin receptor signaling molecules . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
We describe a novel human adapter molecule containing a pleckstrin homolgy ( PH ) domain at the N terminus that is closely related to human Grb 2 associated binder 1 , Gab 1 , and Drosophila daughter of sevenless . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
The HGF receptor directly activates PI 3 kinase , Ras and STAT signalling pathways and phosphorylates the adaptator GRB 2 Associated Binder 1 ( Gab 1 ) . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Gab 1 and Gab 2 ( Grb 2 associated binder 1 and 2 ) are scaffolding adapter molecules that display sequence similarity with Drosophila DOS ( daughter of sevenless ) , which is a potential substrate for the protein tyrosine phosphatase , Corkscrew , Both Gab 1 and Gab 2 , like DOS , have a pleckstrin homology domain and potential binding sites for SH 2 and SH 3 domains . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Insulin and IGF 1 stimulated PI 3 K activity was mainly associated with insulin receptor substrate ( IRS ) isoforms IRS 1 and IRS 2 and less so with the IRS isoform Grb 2 associated binder 1 ( Gab 1 ) . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Interestingly , NS5A could also form a complex with the Grb 2 associated binder 1 ( Gab 1 ) protein in an EGF treatment dependent manner . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
A role for Grb 2 associated binder 1 in growth hormone signaling . ^^^ In this study we investigate potential roles for the pleckstrin homology ( PH ) domain containing insulin receptor substrate like protein , Grb 2 associated binder 1 ( Gab 1 ) , in GH signaling . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
CagA could represent a bacterial adaptor protein that associates with phospholipase Cgamma but not Grb 2 associated binder 1 or growth factor receptor bound protein 2 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
In this study , we show that overexpression of Grb 2 associated binder 1 ( Gab 1 ) promotes cell cycle progression when Tpr Met is expressed at suboptimal levels . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
The proteins Gab 1 and the related DOS ( for ' daughter of sevenless ' ) each bind to substrates of tyrosine kinases like Grb 2 or Corkscrew , and act in signalling pathways downstream of tyrosine kinase receptors . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Efficient cellular transformation by the Met oncoprotein requires a functional Grb 2 binding site and correlates with phosphorylation of the Grb 2 associated proteins , Cbl and Gab 1 . ^^^ We show here that the 110 kDa Tpr Met substrate corresponds to the recently identified Grb 2 associated protein , Gab 1 . ^^^ Moreover , we show that tyrosine phosphorylation of the Cbl protooncogene product as well as Gab 1 required Tyr 489 and correlated with the ability of Tpr Met to associate with Grb 2 and to transform cells , providing evidence that pathways downstream of Gab 1 and / or Cbl may play a role in Tpr Met mediated cell transformation . . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Gab 1 coupling to the HGF / Met receptor multifunctional docking site requires binding of Grb 2 and correlates with the transforming potential . ^^^ It has recently been shown that the Met receptor interacts with Gab 1 , an IRS like adaptor protein , via the docking site ( Y1349VHVNATY1356VNV ) known to bind Grb 2 and multiple SH 2 containing signal transducers . ^^^ Interestingly , the mutations of either Y 1356 or N 1358 abolished the binding of both Grb 2 and Gab 1 in intact cells . ^^^ Furthermore , peptides designed to block either the SH 2 or the SH 3 domains of Grb 2 interfered with the receptor Gab 1 interaction . ^^^ These data indicate that Gab 1 coupling to the Met receptor requires binding of Grb 2 and correlates with the transforming potential of Tpr Met . . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Moreover , tyrosine phosphorylation of Gab 1 correlated with the binding of several SH 2 containing signaling proteins to Gab 1 including Shc , Grb 2 , phosphatidylinositol 3 kinase , and the SHP 2 tyrosine phosphatase . ^^^ In contrast , the Grb 2 SH2 domain did not bind directly to Gab 1 but instead to the Shc and SHP 2 associated with Gab 1 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
In this study , we report the molecular cloning of a novel adaptor like protein , Grap 2 ( Grb 2 related adaptor protein 2 ) , using the multisubstrate docking protein Gab 1 as bait in the yeast two hybrid system . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Although the mutated receptor had lost its ability to recruit and / or activate known signaling molecules , such as GRB 2 , SHC , GAB 1 , and PI3K , by using a sensitive association kinase assay we found that the mutated receptor can still associate and phosphorylate a approximately 250 kDa protein . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
GAB 1 was also associated with the molecular adapter GRB 2 in unstimulated cells , and this association dramatically increased after Epo stimulation . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Besides binding motifs for phosphatidylinositol 3 kinase and Grb 2 , Gab 1 contains multiple Tyr 10 10 Pro ( YXXP ) motifs which , when phosphorylated , are potential binding sites for the adapter proteins c Crk and Crk like ( CRKL ) . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Coupling of Gab 1 to c Met , Grb 2 , and Shp 2 mediates biological responses . ^^^ In addition , Gab 1 is engaged in a constitutive complex with the adaptor protein Grb 2 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
First , we report that PDGF stimulates the G ( 1 ) mediated tyrosine phosphorylation of the Grb 2 adaptor protein , Gab 1 . ^^^ This phosphorylation appears to be necessary for association of PI3K1a with the Gab 1 Grb 2 complex . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
PY 105 associated with Grb 2 and SHP 2 , and although it behaved like Gab 1 , none of the latter was detected in rat liver . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
In response to GDNF stimulation , SHC bound to GAB 1 and GRB 2 adaptor proteins as well as RET , and SHC and GAB 1 were highly phosphorylated on tyrosine . ^^^ The complex formation consisting of SHC , GAB 1 and GRB 2 was almost abolished by replacement of tyrosine 1062 in RET with phenylalanine . ^^^ Tyrosine phosphorylated GAB 1 was also associated with p 85 subunit of PI 3 K , resulting in PI 3 K and AKT activation , whereas SHC GRB 2 SOS complex was responsible for the RAS / ERK signaling pathway . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Flt 3 ligand induces tyrosine phosphorylation of gab 1 and gab 2 and their association with shp 2 , grb 2 , and PI 3 kinase . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Because a number of signaling molecules such as Grb 2 , phosphatidylinositol 3 kinase , and Gab 1 bind to the multifunctional docking site , we further performed an in vitro competition study using glutathione S transferase or His tagged signaling molecules with c Met tyrosine kinase . ^^^ Our binding study revealed that SHIP 1 , Grb 2 , and Gab 1 bound preferentially over phosphatidylinositol 3 kinase . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
The multisubstrate docking site mediates the binding of several adapter proteins such as Grb 2 , SHC , Crk / CRKL , and the large adapter protein Gab 1 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
These results show that , in addition to Shc and Grb 2 , a PI3K dependent pathway involving Gab 1 and SHP 2 is essential for Ras activation under EGF stimulation . . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Gab 1 expression also increased BCR induced tyrosine phosphorylation of SHP 2 as well as the binding of Grb 2 to SHP 2 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
BACKGROUND : The mammalian Grb 2 adaptor protein binds pTyr 10 Asn motifs through its SH 2 domain , and engages downstream targets such as Sos 1 and Gab 1 through its SH 3 domains . ^^^ Analysis of E89K / Delta Grb 2 mutant fibroblasts revealed a marked defect in ERK / MAP kinase activation and Gab 1 tyrosine phosphorylation following growth factor stimulation . ^^^ The placental defects in E89K / Delta mutant embryos are reminiscent of those seen in receptor tyrosine kinase , Sos 1 , and Gab 1 deficient embryos , consistent with the finding that endogenous Grb 2 is required for efficient RTK signaling to the Ras MAP kinase and Gab 1 pathways . . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
In this study , we show that upon thrombopoietin ( Tpo ) stimulation the two adapter proteins Gab 1 and Gab 2 are strongly tyrosine phosphorylated and associated with Shc , SHP 2 , PI 3 kinase and Grb 2 in mpl expressing UT 7 cells . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
In these cells , PI3K was constitutively associated with the molecular adapters Grb 2 and Gab 1 , and with the phosphatases SHP 2 and SHIP . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
ShcA and Grb 2 mediate polyoma middle T antigen induced endothelial transformation and Gab 1 tyrosine phosphorylation . ^^^ PymT mimics activated receptor tyrosine kinases by forming a ShcA Grb 2 Gab1 complex , thus inducing Gab 1 tyrosine phosphorylation , which itself is associated with PI3K . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Sos 1 and the docking protein Gab 1 are brought into the MT complex through Grb 2 association and this may be more effective using the 239 / 240YY sequence . . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Tyrosine phosphorylation stimulates PI3K and PLCgamma 1 enzymatic activity , and on ShcA creates binding sites for Grb 2 with its associated Sos 1 and Gab 1 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Consistent with the ability of Grb 2 to recruit SOS and Gab 1 , the Ras / MAPK and PI3K pathways are activated by Sf Stk , and both of these pathways are required for gp 55 mediated erythroblast proliferation . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
In contrast , Gab 1 recruitment to Met is both Grb 2 dependent and Grb 2 independent . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
NTAL becomes rapidly tyrosine phosphorylated upon cross linking of the B cell receptor ( BCR ) or of high affinity Fcgamma and Fc epsilon receptors of myeloid cells and then associates with the cytoplasmic signaling molecules Grb 2 , Sos 1 , Gab 1 , and c Cbl . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
The PER mutant with all five autophosphorylation sites mutated to phenylalanine ( 5YF ) was equivalently capable of interacting with several important signaling molecules , including Shc , Grb 2 , Gab 1 , phospholipase Cgamma , and Cbl . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Signalling from pTyr ( YB ) was affected by a haplosufficiency in drk ( Grb 2 ) , and in genes thought to function downstream of Grb 2 : dab , sos , csw ( Shp 2 ) , and dos ( Gab 1 ) . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
In general , recruitment of Gab 1 occurs indirectly , via the adapter protein Grb 2 . ^^^ Grb 2 independent recruitment of Gab 1 requires the C terminal lobe and structural integrity of the Met receptor kinase domain . ^^^ In addition , Gab 1 interacts with the Met / hepatocyte growth factor receptor in a Grb 2 independent manner . ^^^ Alternatively , the structural integrity of the Met receptor , and residues upstream of Tyr 1349 located in the C terminal lobe of the kinase domain , are required for Grb 2 independent interaction with the Gab 1 MBD . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Gab 1 and Gab 2 are scaffolding proteins acting downstream of cell surface receptors and interact with a variety of cytoplasmic signaling proteins such as Grb 2 , Shp 2 , phosphatidylinositol 3 kinase , Shc , and Crk . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
Thus , similar to the bisphosphoryl tyrosine based activation motif ( BTAM ) by which the Grb 2 associated binder ( Gab 1 ) , PDGF receptor , and PECAM 1 recruit SHP 2 , BTLA also relies on dual ITIMs for its association with the phosphatases SHP 1 and SHP 2 . . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
We found that PDGF induced a rapid Gab 1 phosphorylation , which depended on the recruitment of Grb 2 , indicating that Grb 2 acts as a bridge between Gab 1 and the PDGF beta receptor . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
ERK1 / 2 associates with the c Met binding domain of growth factor receptor bound protein 2 ( Grb 2 ) associated binder 1 ( Gab 1 ) : role in ERK1 / 2 and early growth response factor 1 ( Egr 1 ) nuclear accumulation . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
We found that the MAPK pathway protein set consisting of the following gene products was present : FRS 2 alpha , GRB 2 , GAB 1 , SOS 1 , Ha ras , Raf1 / RafB , MEK 1 , 2 , 5 , MAPK / ERK1 , 2 , MAPK / ERK5 , and RSK 1 , 2 , 3 ( see abbreviations ) . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
These included FRS2alpha , GAB 1 , GRB 2 , SOS 1 , Raf B , and Raf 1 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
The effector pathway from the EGFR to PI3K in these nontransformed cells included the adaptor Grb 2 , the docking protein Gab 1 , and the phosphatase Shp 2 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
To conduce these activities , the cytoplasmic C terminal region of this receptor acts as a docking site for multiple protein substrates , including Grb 2 , Gab 1 , STAT 3 , Shc , SHIP 1 and Src . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
GRB 2 mediated recruitment of GAB 2 , but not GAB 1 , to SF STK supports the expansion of Friend virus infected erythroid progenitor cells . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
The Grb 2 associated binder ( Gab ) adaptor / scaffolding protein family comprises conserved proteins : mammalian Gab 1 , Gab 2 and Gab 3 , Drosophila Dos and Caenorhabditis elegans Soc 1 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
We observed that the Grb 2 bound adapter Gab 1 is tyrosine phosphorylated and relocated to membrane fractions upon VEGF stimulation of endothelial cells . ^^^ Transfection of other Gab 1 mutants , lacking Grb 2 binding sites or the pleckstrin homology ( PH ) domain , also prevented Akt activation , further demonstrating Gab 1 involvement in PI3K activation . ^^^ These mutants were also used to show that interactions with both Grb 2 and PtdIns ( 3 , 4 , 5 ) P 3 mediate Gab 1 recruitment by VEGFR 2 . ^^^
Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: Q13480 and P62993	Pubmed	SVM Score :0.0
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