| Interacting proteins: Q08881 and P62993 |
Pubmed |
SVM Score :0.0 |
| Lck and p59Fyn regulate CD 28 binding to phosphatidylinositol 3 kinase , growth factor receptor bound protein GRB 2 , and T cell specific protein tyrosine kinase ITK : implications for T cell costimulation . ^^^ CD 28 interacts with three intracellular proteins phosphatidylinositol 3 kinase ( PI 3 kinase ) , T cell specific protein tyrosine kinase ITK ( formerly TSK or EMT ) , and the complex between growth factor receptor bound protein 2 and son of sevenless guanine nucleotide exchange protein ( GRB 2 SOS ) . ^^^ |
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| Interacting proteins: Q08881 and P62993 |
Pubmed |
SVM Score :0.0 |
| In this work , we show binding of WASP to the Src homology 3 domains of Btk , Itk , Tec , Grb 2 , and phospholipase C gamma , which suggests a function for WASP in lymphoid cell signaling . . ^^^ |
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| Interacting proteins: Q08881 and P62993 |
Pubmed |
SVM Score :0.0 |
| Formation of this intramolecular SH 3 ligand complex prevents the Itk SH 3 domain and proline rich region from interacting with their respective protein ligands , Sam 68 and Grb 2 . ^^^ |
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| Interacting proteins: Q08881 and P62993 |
Pubmed |
SVM Score :0.0 |
| The co stimulatory antigen CD 28 has been shown to bind to several intracellular proteins including phosphatidylinositol 3 kinase , growth factor receptor bound protein 2 ( Grb 2 ) , and ITK . ^^^ |
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| Interacting proteins: Q08881 and P62993 |
Pubmed |
SVM Score :0.0 |
| Second , the Itk proline rich region binds to Grb 2 and LAT . ^^^ |
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| Interacting proteins: Q08881 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
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| Interacting proteins: Q08881 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
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