| Interacting proteins: Q07912 and P62993 |
Pubmed |
SVM Score :0.70277641 |
| Furthermore , we observed association of ACK with an adaptor protein Grb 2 , which may suggest the involvement of Grb 2 in EGF receptor mediated tyrosine phosphorylation of ACK . . 0.70277641^^^ |
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| Interacting proteins: Q07912 and P62993 |
Pubmed |
SVM Score :0.0 |
| The role of the two ACK 1 binding proteins Cdc 42 and Grb 2 was assessed by overexpression of the Cdc42 / Rac interactive binding domain and a dominant negative Grb 2 mutant , respectively . ^^^ Specific inhibition of the interaction of ACK 1 with Cdc 42 or Grb 2 by the use of these constructs diminished tyrosine phosphorylation of both ACK 1 and Dbl in response to EGF . ^^^ Therefore , the activation of ACK 1 and subsequent downstream signaling require both Cdc 42 dependent and Grb 2 dependent processes within the cell . ^^^ |
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| Interacting proteins: Q07912 and P62993 |
Pubmed |
SVM Score :0.0 |
| In addition to interactions with multiple signaling adaptors Grb 2 , SHC , SCK , and NSP 2 , EGF receptors in HN 5 cells were shown to form direct or indirect physical interactions with additional kinases including ACK 1 , focal adhesion kinase ( FAK ) , Pyk 2 , Yes , EphA 2 , and EphB 4 . ^^^ |
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| Interacting proteins: Q07912 and P62993 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein ( Grb 2 in mammals or SEM 5 in C . elegans ) may serve as a regulated scaffold for the binding of other signaling proteins that include both positive ( Ras ) and negative ( ACK ) regulators . ^^^ |
|
| Interacting proteins: Q07912 and P62993 |
Pubmed |
SVM Score :0.0 |
| In addition to its stimulation of RAS activity , the GRB 2 homolog SEM 5 acts negatively on both signaling pathways , as does the Ack related kinase ARK 1 . . ^^^ |
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| Interacting proteins: Q07912 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07912 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|