| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| It was also found that Crk 1 , Crk 2 , p 130 ( Cas ) , p 85 PI3K , Grb 2 , and Sos 1 were components of CIN 85 complexes . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| Networks of interaction of p120cbl and p130cas with Crk and Grb 2 adaptor proteins . ^^^ In unstimulated cells , while Grb 2 is not bound to any tyrosine phosphoprotein , Crk is bound via its SH 2 domain to tyrosine phosphorylated p130cas , the Crk associated 5 Src substrate . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| Fibronectin stimulated signaling from a focal adhesion kinase c Src complex : involvement of the Grb 2 , p130cas , and Nck adaptor proteins . ^^^ Tyr ) and Grb 2 binding to FAK were reduced , whereas the tyrosine phosphorylation of another signaling protein , p130cas , was not detected in the Src cells . ^^^ Stable expression of residues 1 to 298 of Src ( Src 1 298 , which encompass the SH 3 and SH 2 domains of c Src ) in the Src cells blocked Grb 2 binding to FAK ; but surprisingly , Src 1 298 expression also resulted in elevated p130cas P . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| FAK interacts with a number of signaling and cytoskeletal proteins , including Src , phosphatidylinositol 3 kinase , Grb 2 , p130Cas and paxillin . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| In this report , we provide evidence that the protein tyrosine kinase Src and adaptor proteins Grb 2 , Crk , and p130Cas act as downstream mediators of Pyk 2 leading to the activation of extracellular signal regulated kinase ( ERK ) and c Jun amino terminal kinase ( JNK ) . ^^^ Pyk 2 induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb 2 and Crk , respectively , and for the activation of ERK and JNK cascades . ^^^ Grb 2 with a deleted carboxyl terminal Src homology 3 domain partially blocked Pyk 2 induced ERK and JNK pathways , whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk 2 . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| FAK associates with several different signaling proteins such as Src family PTKs , p130Cas , Shc , Grb 2 , PI 3 kinase , and paxillin . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| In contrast , LAR selectively inhibited the epidermal growth factor ( EGF ) induced phosphorylation of p130CAS and the formation of the complex between p130CAS and GRB 2 but this effect did not influence the activation of MAPK by EGF . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| It was found in complexes with many signaling proteins , including phosphoinositol ( PtdIns ) 3 kinase ( EC 2 . 7 . 1 . 137 ) , Cbl , GRB 2 , p130Cas and Crk . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The SH 2 containing adapter protein Crk underwent glucose induced association with p130Cas , while other SH 2 containing proteins such as grb 2 , PI 3 kinase , Shp 2 , paxillin , and pyk 2 did not . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| In this study , we establish that PTP1B interacts with Crk , Grb 2 , and p 130 ( Cas ) in vitro and with at least one of these , p 130 ( Cas ) , in intact cells . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| Expression of wild type and Phe 925 FAK , but not Phe 397 FAK , enhanced p 130 ( Cas ) association with FAK , Shc tyrosine phosphorylation , and Grb 2 binding to Shc after FN stimulation . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| In this report , we have examined the role of FAK association with Grb 2 and p 130 ( Cas ) , two downstream events of the FAK / Src complex that could mediate integrin stimulated activation of extracellular signal regulated kinases ( Erks ) . ^^^ Together , these results demonstrate that p 130 ( Cas ) , but not Grb 2 , is a mediator of FAK promoted cell migration and suggest that FAK / p 130 ( Cas ) complex targets downstream pathways other than Erks in mediating FAK promoted cell migration . . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| The latter sequences mediate the binding to the SH 3 domains of p 130 ( Cas ) , Src family kinases , p 85 subunit of phosphatidylinositol 3 kinase , and Grb 2 . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| Cas dependent SRE activation was accompanied by an increase in the level of active Ras and in the activity of the mitogen activated protein kinase ( MAPK ) Erk 2 ; these changes were blocked by coexpression of dominant negative mutants of the adapter protein Grb 2 . ^^^ Coexpression of Cas with 5 Src enhanced the association of Grb 2 with the adapter protein Shc and the protein tyrosine phosphatase Shp 2 ; coexpression of Shc or Shp 2 mutants significantly reduced SRE activation by Cas and 5 Src . ^^^ Cas induced Grb 2 association with Shp 2 and Shc may account for the Cas dependent activation of the Ras / Mek / Erk pathway and SRE dependent transcription . 14 3 3 proteins may also play a role in Cas mediated signaling to the SRE . ^^^ |
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| Interacting proteins: P56945 and P62993 |
Pubmed |
SVM Score :0.0 |
| Finally , we provide evidence that the Src dependent association of FAK with Grb 2 and p 130 ( Cas ) are both required for the regulation of cell cycle progression by FAK . ^^^ |
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