| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.92276252 |
| Grb 2 dominantly associates with dynamin 2 in human hepatocellular carcinoma HepG 2 cells . 0.92276252^^^ |
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| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.99888425 |
| The SH 3 mediated association of Grb 2 with dynamin 2 was confirmed by competitive binding experiments with oligopeptides whose sequence corresponded to that of SH 2 or SH 3 binding motif . 0.99888425^^^ Dynamin 2 associates with Grb 2 SH3 domain in Ras transformed NIH3T3 cells . 0.94472131^^^ |
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| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| Dynamin 2 has a higher basal activity than dynamin 1 , but the two types of dynamin are stimulated similarly by microtubules , Grb 2 , and phospholipids . ^^^ |
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| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| Using rat cultured hepatocytes stimulated by hepatotrophic factors and regenerating livers after partial hepatectomy ( PH ) we examined GRB 2 mediated linkage of hepatotrophic factor receptors to signal transducing molecules such as Sos or dynamin 2 by immunoprecipitation and western blot analysis . ^^^ In contrast , in primary cultured hepatocytes stimulated with insulin , GRB 2 linked insulin receptor substrate 1 ( IRS 1 ) to dynamin 2 as well as Sos . ^^^ In the late phase after PH , a complex of IRS 1 GRB 2 associated with dynamin 2 , indicating that GRB 2 may transduce signals from IRS 1 to dynamin 2 . ^^^ |
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| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| Gi mediated tyrosine phosphorylation of Grb 2 ( growth factor receptor bound protein 2 ) bound dynamin 2 by lysophosphatidic acid . ^^^ Through glutathione S transferase Grb 2 affinity purification and microsequencing , we have now identified p 100 as dynamin 2 , a GTPase that regulates clathrin mediated endocytosis . ^^^ We show that in Rat 1 cells , Grb 2 bound dynamin 2 is rapidly tyrosine phosphorylated in response to LPA in a PTX sensitive manner . ^^^ Thus , tyrosine phosphorylation of Grb 2 bound dynamin 2 may be a critical event in Gi mediated activation of the Ras MAP kinase cascade in fibroblasts . . ^^^ |
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| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| For example , SH 3 domains from c Src , Grb 2 , and intersectin bound only to the C terminal half of dynamin 2 PRD but to both the N and C terminal portions of dynamin 1 PRD . ^^^ |
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| Interacting proteins: P50570 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 , a 24 kDa adaptor protein and an essential element of the Ras signaling pathway , was found to be associated with dynamin 2 and myosin 2 gene expression in the Ras transformed NIH3T3 cells . ^^^ |
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