Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
In contrast , Grb 2 , Crk , Abl , p 85 phosphatidylinositol 3 kinase , and GTPase activating protein SH 2 domains showed lower or no binding to Fyn or Lck SH 3 domains . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Crk , a cellular homolog of 5 crk , is an SH 2 and SH 3 domain containing adaptor protein related to Grb 2 and Nck , two proteins which have been shown to be involved in growth factor signal transduction . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The results demonstrate that , in addition to Grb 2 , CRK participates in signaling from the NGF receptor and that two GNRPs appear to transmit signals from these adaptor molecules to Ras . . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
We have used activation of the mitogen activated protein kinase Erk 1 as a model system with which to examine whether various dominant negative SH2 / SH3 adapters ( Grb 2 , Crk , and Nck ) could block signaling pathways leading to Erk activation . ^^^ Activation of Erk 1 by oncogenic Abl was effectively inhibited by Grb 2 with mutations in either its SH 2 or SH 3 domain or by Crk 1 with an SH 3 domain mutation . ^^^ These results suggest that both Crk and Grb 2 may contribute to the activation of Erk by oncogenic Abl , whereas Nck is unlikely to participate in this pathway . ^^^ When combinations of Crk 1 and Grb 2 mutants were analyzed , the combination of the Crk 1 SH 3 mutant plus the Grb 2 SH3 mutant gave a striking synergistic effect . ^^^ This finding suggests that in Abl transformed cells , more than one class of tyrosine phosphorylated sites ( those that bind the Grb 2 SH2 domain and those that bind the Crk SH 2 domain ) can lead to Ras activation . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
All CRK binding proteins except clone ST 12 also bound to another adaptor protein , Grb 2 . ^^^ Mutational analysis revealed that glycine at position +1 of ST 12 inhibited the binding to Grb 2 while retaining the high affinity binding to CRK SH 3 . ^^^ The result suggests that the amino acid at position +1 also contributes to the high affinity binding of the peptides to the SH 3 domain of Grb 2 , but not to that of CRK . . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Networks of interaction of p120cbl and p130cas with Crk and Grb 2 adaptor proteins . ^^^ In unstimulated cells , while Grb 2 is not bound to any tyrosine phosphoprotein , Crk is bound via its SH 2 domain to tyrosine phosphorylated p130cas , the Crk associated 5 Src substrate . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Cbl not only interacts with Grb 2 , but also with the adaptor protein Crk . ^^^ In contrast to its constitutive interaction with Grb 2 , tyrosine phosphorylated Cbl only associates with Crk after BCR stimulation . ^^^ In summary , we observe that the BCR activates Shc / Grb2 , Grb 2 and Crk adaptor complexes of distinct composition , which may allow selective coupling to different signal transduction cascades . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
In this study , we establish that PTP1B interacts with Crk , Grb 2 , and p 130 ( Cas ) in vitro and with at least one of these , p 130 ( Cas ) , in intact cells . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Sos , Vav , and C3G participate in B cell receptor induced signaling pathways and differentially associate with Shc Grb 2 , Crk , and Crk L adaptors . ^^^ Instead , Vav was found to inducibly associate with the Grb 2 related adaptor protein Crk upon BCR stimulation . ^^^ C3G did not bind to either Grb 2 , Shc , or Crk in vivo . ^^^ These guanine nucleotide exchange factors selectively associate with Grb 2 , Crk , and Crk L , respectively , which may serve to direct them to different target molecules . ^^^ Since Cbl binds to Grb 2 , Crk , as well as Crk L , we hypothesize that Cbl may affect the function of all three exchangers . . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
In these cells , IRS 1 and 4PS both associated with Crk , and this association was also decreased by IGF 1 treatment , whereas the association of Grb 2 with IRS 1 and 4PS was enhanced by IGF 1 . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Interactions of Cbl with two adapter proteins , Grb 2 and Crk , upon T cell activation . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb 2 . ^^^ Specifically , we have found that the Src SH 3 domain selects peptides sharing the consensus motif LXXRPLPXpsiP , whereas Yes SH 3 selects psiXXRPLPXLP , Abl SH 3 selects PPXthetaXPPPpsiP , Cortactin SH 3 selects +PPpsiPXKPXWL , p53bp2 SH 3 selects RPXpsiPpsiR+SXP , PLCgamma SH 3 selects PPVPPRPXXTL , Crk N terminal SH 3 selects psiPpsiLPpsiK , and Grb 2 N terminal SH 3 selects +thetaDXPLPXLP ( where psi , theta , and + represent aliphatic , aromatic , and basic residues , respectively ) . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The protein product of c cbl proto oncogene is known to interact with several proteins , including Grb 2 , Crk and PI 3 kinase , and is thought to regulate signalling by many cell surface receptors . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
In this report , using a constitutively activated Ret TK form , Ret ptc 2 , we demonstrate that the MEN 2B as the activated WT Ret TK binds to several SH 2 signalling proteins such as Shc , Grb 2 , Phospholipase Cgamma , Crk and Nck . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
In addition , Reps 1 has the capacity to form a complex with the SH 3 domains of the adapter proteins Crk and Grb 2 , which may link Reps 1 to an EGF responsive tyrosine kinase . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Furthermore , POB 1 bound to Grb 2 but not to Nck or Crk . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The simplest of SH2 / SH3 containing proteins are the Crk , Grb 2 and Nck adaptor proteins which contain SH 2 and SH 3 domains but no intrinsic catalytic activity . ^^^ Whereas Grb 2 connects activated receptor tyrosine kinases with Sos and activates p21ras , recent evidence suggests that this may not be the major mechanism by which Crk and Nck signal to downstream effectors . ^^^ Identification of novel binding partners for Crk , Grb 2 and Nck indicate that these adaptor proteins control distinct aspects of tyrosine kinase signalling . . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The amount of Cbl associated with CrkL and CrkII exceeded the fraction of Cbl associated with Grb 2 indicating that unlike other receptor systems , the Cbl Crk association represents the dominant complex of Cbl in growth factor stimulated hematopoietic cells . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The molecular adapter c Cbl is rapidly tyrosine phosphorylated following stimulation through the TCR and associates with Src homology domain 2 ( SH 2 ) / SH3 domain containing adapters such as Grb 2 , Crk , and Crk L , which interact with guanine nucleotide exchange factors specific for the Ras family . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Enhancement of guanine nucleotide exchange activity of C3G for Rap 1 by the expression of Crk , CrkL , and Grb 2 . ^^^ In the present study , we analyzed the effect of Crk , CrkL , and Grb 2 on the C3G Rap 1 pathway . ^^^ Expression of Crk , CrkL , and Grb 2 with C3G in Cos 1 cells significantly increased the ratio of GTP / GDP bound to Rap 1 . ^^^ These results demonstrate that Crk , CrkL , and Grb 2 positively modulate the C3G Rap 1 pathway primarily by recruiting C3G to the cell membrane . . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Cbl serves as a substrate of both receptor and non receptor tyrosine kinases , and binds to adaptor proteins Grb 2 , Crk and the p 85 subunit of PI 3 kinase . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
In vitro protein binding studies using synthetic peptides and immunoblotting showed that phospholipase C gamma binds to both Y ( p ) 1213 and Y ( p ) 1333 , whereas Grb 2 and SH 2 containing tyrosine protein phosphatase ( SHP 2 ) bind to Y ( p ) 1213 , and Nck and Crk bind to Y ( p ) 1333 in a phosphotyrosine dependent manner . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Among them we confirmed molecules already shown by others to interact with Bcr Abl , in vivo , including Grb 2 , PI 3 kinase and Crk indicating that dimerization in yeast leads to autophosphorylation of tyrosine residues crucial for Bcr Abl signaling in vivo . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
While KHS bound exclusively to Crk family proteins , HPK 1 also interacted with both SH 3 domains of Grb 2 and weakly with Nck , but not with more than 25 other SH 3 domains tested . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The SH2 / SH3 adapters Nck , Grb 2 and Crk promote the assembly of signaling complexes by binding to tyrosine phosphorylated proteins using their SH 2 domains and to proline rich sequences on effector molecules using their SH 3 domains . ^^^ We present evidence that dominant negative mutants of Nck and Grb 2 , but not Crk 1 , can inhibit mesoderm specific gene induction by eFGF in Xenopus animal cap explants . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
We found that HPK 1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline rich motifs within HPK 1 were involved in the differential interaction of HPK 1 with the Crk proteins and Grb 2 . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Consistent with this model , FRS 2 binds Grb 2 , Crk , the SH 2 domain containing tyrosine phosphatase SH PTP 2 , the cyclin dependent kinase substrate p 13 ( suc 1 ) , and the Src homology 3 ( SH 3 ) domain of Src , providing a functional link between TrkA , cell cycle , and multiple NGF signaling effectors . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Adaptor proteins Grb 2 and Crk couple Pyk 2 with activation of specific mitogen activated protein kinase cascades . ^^^ In this report , we provide evidence that the protein tyrosine kinase Src and adaptor proteins Grb 2 , Crk , and p130Cas act as downstream mediators of Pyk 2 leading to the activation of extracellular signal regulated kinase ( ERK ) and c Jun amino terminal kinase ( JNK ) . ^^^ Pyk 2 induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb 2 and Crk , respectively , and for the activation of ERK and JNK cascades . ^^^ Grb 2 with a deleted carboxyl terminal Src homology 3 domain partially blocked Pyk 2 induced ERK and JNK pathways , whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk 2 . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The major function of these adaptors , such as Grb 2 , Nck , and Crk , is to recruit proline rich effector molecules to tyrosine phosphorylated kinases or their substrates . ^^^ In this review , the author attempts to summarise these novel binding partners of Grb 2 , Nck , and Crk , and to discuss current controversies regarding function and regulation of protein multicomplexes held together by SH2 / SH3 adaptor molecules at the plasma membrane . . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
HPK 1 interacts , through its proline rich domains , with growth factor receptor bound 2 ( Grb 2 ) , CT 10 regulated kinase ( Crk ) , and Crk like ( CrkL ) adaptor proteins . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Unlike the full length HPK 1 , the N terminal cleaved product failed to bind adaptor molecules Grb 2 ( growth factor receptor bound protein 2 ) and Crk ( CT 10 regulator of kinase ) . ^^^ The C terminal fragment , although having three proline rich domains , bound to Grb 2 and Crk less efficiently than the full length HPK 1 protein . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Overlay blots with recombinant Src homology 2 domains of IRS 1 adaptor proteins showed that the loss of IRS 1 binding of Crk , GRB 2 , SHP 2 , and the p 85 subunit of phosphatidylinositol 3 ' kinase paralleled the rate of overall IRS 1 dephosphorylation . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The highest binding was observed with SH 3 domains of c Src , phospholipase C gamma , p 85 subunit of phosphatidylinositol 3 kinase , full length and NH ( 2 ) terminal Grb 2 , whereas binding was moderate with the SH 3 domains of amphiphysins I / II , Crk , alpha spectrin , and NADPH oxidase factor p 47 ( phox ) and negligible with the SH 3 domains of p 21 ( ras ) GTPase activating protein and COOH terminal Grb 2 . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Upon TCR / CD3 stimulation , HPK 1 formed inducible complexes with the adapters Nck and Crk with different kinetics , whereas it constitutively interacted with the adapters Grb 2 and CrkL in Jurkat T cells . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Initially , it was not clear why cells from nematodes to vertebrates contain redundant and closely related SH2 / SH3 adapters , such as Grb 2 , Crk and Nck . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
It was found in complexes with many signaling proteins , including phosphoinositol ( PtdIns ) 3 kinase ( EC 2 . 7 . 1 . 137 ) , Cbl , GRB 2 , p130Cas and Crk . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
VEGF treatment of KDR expressing cells leads to the recruitment of Nck , p 21 activated kinase , Crk , Grb 2 , and protein kinase C l to FRS 2 . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Incubation of various glutathione S transferase fusion proteins with a lysate of activated Jurkat cells resulted in selective association of ZAP 70 with Crk , but not Grb 2 or Nck , adapter proteins . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Insulin receptor phosphorylated IRS5 / DOK4 associates with RasGAP , Crk , Src , and Fyn , but not phosphatidylinositol 3 kinase p 85 , Grb 2 , SHP 2 , Nck , or phospholipase Cgamma Src homology 2 domains , and activates MAPK in cells . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Gab 1 and Gab 2 are scaffolding proteins acting downstream of cell surface receptors and interact with a variety of cytoplasmic signaling proteins such as Grb 2 , Shp 2 , phosphatidylinositol 3 kinase , Shc , and Crk . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
These proteins contain a set of sequences providing interactions with a wide range of receptor and nonreceptor tyrosine kinases and signaling proteins with SH 2 and SH 3 domains ( for example , EGF and PDGF receptors , Src kinases , PI 3 kinase p 85 , Crk , GRB 2 , Vav , etc . ) . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
RESULTS : The SH 2 containing adapter protein Crk underwent glucose induced association with p130Cas , while other SH 2 containing proteins such as grb 2 , PI 3 kinase , Shp 2 , paxillin , and pyk 2 did not . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
HPK 1 binds many adaptor proteins including members of the Grb 2 family , Nck family , Crk family , SLP 76 family , and actin binding adaptors like HIP 55 . ^^^ The HPK 1 association with Crk , CrkL , and HIP 55 mediate HPK 1 dependent c Jun N terminal kinase ( JNK ) activation , while the association of HPK 1 with SLP 76 , Gads , CrkL , Grb 2 , and Grap affect T and B cell dependent gene transcription . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Direct recruitment of CRK and GRB 2 to VEGFR 3 induces proliferation , migration , and survival of endothelial cells through the activation of ERK , AKT , and JNK pathways . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Potential disease targets for drugs that disrupt protein protein interactions of Grb 2 and Crk family adaptors . ^^^ This review summarises some of the knowledge we have about Crk and Grb 2 family adaptor protein signalling in health and disease and outlines the current status and the challenges still remaining in the development of efficient and selective inhibitors of their protein protein interactions . ^^^ It also highlights briefly some recent successes and problems of inhibitors for proteins that functionally interact with Crk and Grb 2 family adaptors , as well as opportunities , which may arise from combination therapies . ^^^ Grb 2 and Crk family adaptors regulate signalling pathways linked to human diseases . ^^^ Additional molecular targets for Crk and Grb 2 domain interaction blockers are expected to surface as further protein protein interactions are discovered . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Co immunoprecipitation of whole cell extracts demonstrated that the guanylnucleotide exchange factor SOS was associated with the small adapter proteins Grb 2 , CrkII , and Nck . ^^^ In vitro binding indicated a similar binding affinity of SOS for all three adapter proteins but with a slightly lower Kd for Grb 2 ( approximately 2 . 5 fold ) compared with Nck and CrkII . ^^^ Insulin stimulation resulted in co immunoprecipitation of tyrosine phosphorylated IRS 1 with Grb 2 and to a lesser extent CrkII . ^^^ Although Grb 2 also associated with tyrosine phosphorylated Shc , there was no detectable interaction of CrkII with Shc . ^^^ In contrast , EGF stimulation resulted in the predominant co immunoprecipitation of Grb 2 with the EGF receptor , whereas CrkII primarily associated with an unidentified 120 130 kDa protein . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Yet overexpression or reduced expression of Grb 2 in the mutant before and after complementation with crkII have little effect on its phenotype . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The insulin receptor substrate ( IRS ) , SHC , GRB 2 , CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
It interacts with SH 2 containing proteins such as phosphatidylinositol 3 ' kinase ( PI3K ) , Grb 2 , Crk 2 , and CrkL . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Growth factor receptor bound protein 2 ( Grb 2 ) co immunoprecipitated with CrkII species . ^^^ By transient transfection of A 431 human epidermoid carcinoma cells with wild type and dominant negative Grb 2 expression constructs lacking either the SH 2 or SH 3 domains , we have concluded that Grb 2 does not contribute to the ' presentation ' of CrkII to p ( 145betaMET ) . ^^^ Growth factor receptor bound protein 2 ( Grb 2 ) co immunoprecipitated with CrkII species . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
It was also found that Crk 1 , Crk 2 , p 130 ( Cas ) , p 85 PI3K , Grb 2 , and Sos 1 were components of CIN 85 complexes . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
There is an activation induced association of tyrosine phosphorylated Cbl with Grb 2 and CrkL , respectively , but not CrkII . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
Differences were also found between the EPEC and EHEC pedestals : the adapter proteins Grb 2 and CrkII were recruited to the EPEC pedestal but were absent in the EHEC pedestal . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
CSF 1 stimulation induces the formation of a multiprotein complex including CSF 1 receptor , c Cbl , PI 3 kinase , Crk 2 and Grb 2 . ^^^ We demonstrate here that CSF 1 exposure of stable transfectant CHO cells expressing the CSF 1 receptor induced the sustained tyrosine phosphorylation of c Cbl and its subsequent association with Crk 2 and the p 85 kDa subunit of the PI 3 kinase , while it constitutively associates with Grb 2 . ^^^ Thus c Cbl behaves as a core protein , allowing the formation of a quaternary complex including , Crk 2 , PI 3 kinase and Grb 2 . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
EphA activation also induced Cbl association with Crk L and Crk 2 adapters , but not the related Grb 2 protein . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
The adaptor proteins Grb 2 , CrkII , and Nck 1 are composed of only a single Src homology 2 domain and some Src homology 3 domains , giving specificity to each signal transduction pathway . ^^^ Here we showed that Nck 1 , but not Grb 2 or CrkII , mediated the inhibition of cell migration induced by the endothelin 1 and endothelin A receptor . ^^^
Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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Interacting proteins: P46108 and P62993	Pubmed	SVM Score :0.0
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