| Interacting proteins: P20273 and P62993 |
Pubmed |
SVM Score :0.0 |
| To define further the molecular mechanism by which CD 22 mediates its co receptor function , phosphopeptide mapping experiments were conducted to determine which of the six tyrosine residues in the cytoplasmic domain are involved in recruitment of the stimulatory effector proteins phospholipase Cgamma ( PLCgamma ) , phosphoinositide 3 kinase ( PI3K ) , Grb 2 , and Syk . ^^^ |
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| Interacting proteins: P20273 and P62993 |
Pubmed |
SVM Score :0.0 |
| CD 22 forms a quaternary complex with SHIP , Grb 2 , and Shc . ^^^ The adapter proteins Grb 2 and Shc were found to interact with distinct and specific regions of the CD 22 cytoplasmic domain . ^^^ |
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| Interacting proteins: P20273 and P62993 |
Pubmed |
SVM Score :0.0 |
| CD 22 regulates B cell receptor mediated signals via two domains that independently recruit Grb 2 and SHP 1 . ^^^ Furthermore , Grb 2 is inducibly recruited to CD 22 in human and murine B cells . ^^^ Unlike SHP 1 , Grb 2 recruitment to CD 22 is not inhibited by specific doses of the Src family kinase specific inhibitor PP 1 . ^^^ The tyrosine residue in CD 22 required for Grb 2 recruitment ( Tyr 828 ) is distinct and independent from the two ITIM tyrosines required for efficient SHP 1 recruitment ( Tyr 843 and Tyr 863 ) . ^^^ |
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| Interacting proteins: P20273 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20273 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20273 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|