| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.82036477 |
| We show that , dependent on serine hyperphosphorylation , protein tyrosine phosphatase alpha ( PTPalpha ) is activated by two different mechanisms during mitosis : its specific activity increases and its inhibitory binding to Grb 2 decreases . 0.82036477^^^ |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.64618433 |
| It thereby activates Src , and PTPalpha overexpression neoplastically transforms NIH 3T3 cells . pTyr 789 in PTPalpha is constitutively phosphorylated and binds Grb 2 , an interaction that may inhibit PTPalpha activity . 0.64618433^^^ |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of receptor protein tyrosine phosphatase alpha on Tyr 789 , a binding site for the SH 3 SH2 SH 3 adaptor protein GRB 2 in vivo . ^^^ |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| Tight association of GRB 2 with receptor protein tyrosine phosphatase alpha is mediated by the SH 2 and C terminal SH 3 domains . ^^^ Receptor protein tyrosine phosphatase alpha ( RPTPalpha ) , a transmembrane member of the extensive family of protein tyrosine phosphatases ( PTPs ) , is constitutively phosphorylated on Tyr 789 , a consensus binding site for the SH 2 domain of the SH 3 SH2 SH 3 adaptor protein GRB 2 . ^^^ |
|
| Interacting proteins: P18433 and P62993 |
Pubmed |
SVM Score :0.0 |
| Receptor tyrosine phosphatase R PTP alpha is tyrosine phosphorylated and associated with the adaptor protein Grb 2 . ^^^ We report that a ubiquitous R PTPase , R PTP alpha , is tyrosine phosphorylated and associated in vivo with the Grb 2 protein . ^^^ Association requires the presence of an intact SH 2 domain in Grb 2 , as well as tyrosine phosphorylation of R PTP alpha . ^^^ |
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