Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.6457444
In this study , we establish that PTP1B interacts with Crk , Grb 2 , and p 130 ( Cas ) in vitro and with at least one of these , p 130 ( Cas ) , in intact cells . 0.6457444^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.55272904
The associations of PTP1B with IR and with Grb 2 were lower ( P < 0 . 05 ) at 7 than at 26 days of age in muscle , but there were no age effects in liver . 0.55272904^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
Examination of novel non phosphorus containing phosphotyrosyl mimetics against protein tyrosine phosphatase 1B and demonstration of differential affinities toward Grb 2 SH2 domains . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
Finally , some experimental results on the substrate specificity of protein tyrosine phosphatase 1B and the SH 2 domain of the adaptor protein Grb 2 are summarized and discussed . . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
After binding to EGFR , PTP1B becomes tyrosine phosphorylated at Tyr 66 , a site that conforms to the consensus binding sequence for the Src homology 2 ( SH 2 ) domains of the adapter protein Grb 2 . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
We have demonstrated that PTP1B inhibited binding of the adapter protein Grb 2 to p 210 bcr abl and suppressed p 210 bcr abl induced transcriptional activation that is dependent on Ras . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
Further studies revealed that the adaptor protein GRB 2 strongly promoted the formation of a stable protein complex between tyrosine phosphorylated IRS 1 and catalytically inactive PTP1B , increasing their co immunoprecipitation from an equimolar solution by 13 . 5 + / 3 . 3 fold ( n = 7 ; p < 0 . 01 ) . ^^^ Inclusion of GRB 2 in a reaction mixture of IRS 1 and active PTP1B also increased the overall rate of IRS 1 tyrosine dephosphorylation by 2 . 7 3 . 9 fold ( p < 0 . 01 ) . ^^^ These results provide new insight into novel molecular interactions involving PTP1B and GRB 2 that may influence the steady state capacity of IRS 1 to function as a phosphotyrosine scaffold and possibly affect the balance of postreceptor insulin signaling . . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
However , PTP1B / Grb 2 association remained unchanged in both cell types , regardless of insulin stimulation . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
With regard to the large effect on MAPK phosphorylation , we found that PTP1B overexpression led to the impaired phosphorylation of both IRS 1 and Shc , resulting in a decrease in their association with Grb 2 . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
Specimens were stained with PTP1B and IR ( b subunit ) and classified as NASH or ASH . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
The uncovering of a novel regulatory mechanism for PLD 2 : formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor bound protein GRB 2 . ^^^ Systematic co immunoprecipitation immunoblotting experiments pointed at a physical association between PLD 2 , Grb 2 , and PTP1B in both physiological conditions and in overexpressed cells . ^^^ This is the first report of a demonstration of the mammalian isoform PLD 2 existing in a ternary complex with a protein tyrosine phosphatase , PTP1b , and the docking protein Grb 2 which greatly enhances tyrosyl phosphorylation of the lipase . . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
Our laboratory has recently reported that the enzyme phospholipase D 2 ( PLD 2 ) exists as a ternary complex with PTP1b and the growth factor receptor bound protein 2 ( Grb 2 ) . ^^^
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18031 and P62993	Pubmed	SVM Score :0.0
NA